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Abstract

Lumpy skin disease, sheeppox and goatpox are high-impact diseases of domestic ruminants with a devastating effect on cattle, sheep and goat farming industries in endemic regions. In this article, we review the current geographical distribution, economic impact of an outbreak, epidemiology,...

Author(s)
Tuppurainen, E. S. M.; Venter, E. H.; Shisler, J. L.; Gari, G.; Mekonnen, G. A.; Juleff, N.; Lyons, N. A.; Clercq, K. de; Upton, C.; Bowden, T. R.; Babiuk, S.; Babiuk, L. A.
Publisher
Wiley, Berlin, Germany
Citation
Transboundary and Emerging Diseases, 2017, 64, 3, pp 729-745
Abstract

One of the impediments in the development of safe and cost effective vaccines for veterinary use has been the availability of appropriate delivery vehicle. We have chosen to develop and use bovine adenovirus (BAdV)-3 as vaccine delivery vector in cattle. Here, we describe the construction of...

Author(s)
Brownlie, R.; Pankaj Kumar; Babiuk, L. A.; Tikoo, S. K.
Publisher
Springer US, Philadelphia, USA
Citation
Molecular Biotechnology, 2015, 57, 1, pp 58-64
Abstract

Bovine herpesvirus 1 (BoHV-1) causes recurrent respiratory and genital infections in cattle and predisposes them to lethal secondary infections. While modified live and killed BoHV-1 vaccines exist, these are not without problems. Development of an effective DNA vaccine for BoHV-1 has the potential ...

Author(s)
Mackenzie-Dyck, S.; Kovacs-Nolan, J.; Snider, M.; Babiuk, L. A.; Hurk, S. van D. L. van den
Publisher
American Society for Microbiology (ASM), Washington, USA
Citation
Clinical and Vaccine Immunology, 2014, 21, 4, pp 463-477
Abstract

The UL47 gene product, VP8, is one of the most abundant tegument proteins of bovine herpesvirus-1 (BoHV-1). Deletion of VP8 leads to impaired growth in tissue culture, and VP8 is indispensable for BHV-1 replication in cattle. To elucidate the biological functions of VP8, we explored its interaction ...

Author(s)
Islam, A.; Schulz, S.; Afroz, S.; Babiuk, L. A.; Drunen Littel-van den Hurk, S. van
Publisher
Elsevier B. V., Amsterdam, Netherlands
Citation
Virus Research, 2015, 197, pp 116-126
Abstract

Non-methylated CpG motifs, present in viral and bacterial DNA, are one of many pathogen-associated molecular patterns (PAMP) recognized by the mammalian innate immune system. Recognition of this PAMP occurs through a specific interaction with toll-like receptor 9 (TLR9) and this interaction can...

Author(s)
Griebel, P. J.; Brownlie, R.; Anju Manuja; Nichani, A.; Mookherjee, N.; Popowych, Y.; Mutwiri, G.; Hecker, R.; Babiuk, L. A.
Publisher
Elsevier, Amsterdam, Netherlands
Citation
Veterinary Immunology and Immunopathology, 2005, 108, 1/2, pp 11-16
Abstract

Human and murine immature DCs (iDCs) are highly efficient in antigen capture and processing, while as mature cells they present antigen and are potent initiators of cell-mediated immune responses. Consequently, iDCs are logical targets for vaccine antigens. Originally discovered for their...

Author(s)
Mackenzie-Dyck, S.; Attah-Poku, S.; Juillard, V.; Babiuk, L. A.; Littel-van den Hurk, S. van D.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Veterinary Immunology and Immunopathology, 2011, 143, 1/2, pp 87-107
Abstract

Protective efficacy against bovine herpesvirus 1 (BoHV-1) has been demonstrated to be induced by a plasmid encoding bovine neutrophil beta-defensin 3 (BNBD3) as a fusion construct with truncated glycoprotein D (tgD). However, in spite of the increased cell-mediated immune responses induced by this...

Author(s)
Mackenzie-Dyck, S.; Latimer, L.; Atanley, E.; Kovacs-Nolan, J.; Attah-Poku, S.; Babiuk, L. A.; Littel-van den Hurk, S. van D.
Publisher
American Society for Microbiology (ASM), Washington, USA
Citation
Clinical and Vaccine Immunology, 2015, 22, 1, pp 79-90
Abstract

VP8 is the most abundant tegument protein of bovine herpesvirus-1 (BHV-1). In the present study DNA damage binding protein 1 (DDB1) was identified as interacting partner of VP8. MALDI-TOF mass spectroscopy analysis of proteins co-immunoprecipitated with VP8 identified DDB1 as a protein interacting...

Author(s)
Vasilenko, N. L.; Snider, M.; Labiuk, S. L.; Lobanov, V. A.; Babiuk, L. A.; Littel-van den Hurk, S. van D.
Publisher
Elsevier B. V., Amsterdam, Netherlands
Citation
Virus Research, 2012, 167, 1, pp 56-66
Abstract

Author(s)
Babiuk, L. A.; Littel-van den Hurk, S. van D.; Tikoo, S. K.
Publisher
Oxford University Press, Oxford, UK
Citation
Infectious diseases of livestock. Volume Two, 2004, Ed.2, pp 875-886
Abstract

Tegument protein VP8 encoded by the UL47 gene of bovine herpesvirus type 1 (BHV-1) is the most abundant constituent of mature virions. In the present report, we describe the characterization of UL47 gene-deleted BHV-1 in cultured cells and its natural host. The UL47 deletion mutant exhibited...

Author(s)
Lobanov, V. A.; Maher-Sturgess, S. L.; Snider, M. G.; Lawman, Z.; Babiuk, L. A.; Littel-van den Hurk, S. van D.
Publisher
American Society for Microbiology (ASM), Washington, USA
Citation
Journal of Virology, 2010, 84, 1, pp 445-458

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