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Abstract

Copy number variation is a part of genomic structural variation and has caused widespread concern. According to the results of high-throughput screening of the MLLT10 gene, we found that the copy number variation region of the MLLT10 gene was correlated with bovine growth traits. We aimed to detect ...

Author(s)
Yang Peng; Zhang ZiJing; Xu JiaWei; Qu KaiXing; Lyv ShiJie; Wang XianWei; Cai CuiCui; Li ZhiMing; Wang ErYao; Xie JianLiang; Ru BaoRui; Lei ChuZhao; Chen Hong; Huang BiZhi; Huang YongZhen; Xu ZeJun
Publisher
MDPI AG, Basel, Switzerland
Citation
Animals, 2020, 10, 2,
Abstract

Pleiomorphic adenoma gene 1 (PLAG1), locating in growth-related QTNs, was identified significantly affecting the body size of bovine, pig and mouse, while, the relationship between its genetic variation and ovine body size is still unknown. Here, two insertion/deletion (indel) loci of ovine PLAG1,...

Author(s)
Wu Hui; Pan Yun; Zhang QingFeng; Cao Yang; Li Jie; Chen Hong; Cai Yong; Sun XiuZhu; Lan XianYong
Publisher
Elsevier B.V., Amsterdam, Netherlands
Citation
Small Ruminant Research, 2019, 178, pp 63-69
Abstract

Copy number variation is a large genome variation which usually happens in the noncoding-region, and it may occur at the locus associated with the functional gene to further influence the phenotype. Potassium inwardly-rectifying channel, subfamily J 12 (KCNJ12) gene expressed widely in...

Author(s)
Zheng Li; Xu JiaWei; Li JiChao; Wang DaHui; An QingMing; Xu LinNa; Ma YiLei; Wang Jian; Peng ShuJun; Lei ChuZhao; Lan XianYong; Chen Hong; Huo LiJun; Huang YongZhen
Publisher
Elsevier Ltd, Oxford, UK
Citation
Gene, 2019, 689, pp 90-96
Abstract

Activin A receptor type 1 (ACVR1) annotated for its involvement in some key signaling pathways is one promising candidate for economic traits. The aim of this study was to analyze its phenotypic effects on cattle growth traits. Four variations including two intronic Indels and two exonic SNPs were...

Author(s)
Cheng Jie; Cao XiuKai; Hao Dan; Ma YiLei; Qi XingLei; Chaogetu BuRen; Lei ChuZhao; Chen Hong
Publisher
Elsevier B.V., Amsterdam, Netherlands
Citation
Livestock Science, 2019, 229, pp 210-215
Abstract

The heat shock factor 1 (HSF1) gene is a regulator of the heat stress response, maximizing HSP protein expression survival. In this research, we explored the frequency distribution of a missense mutation (NC_037341.1 g.616087A > G, rs135258919) in the HSF1 gene in Chinese cattle with amino acid...

Author(s)
Rong Yu; Zeng MingFei; Guan XiWen; Qu KaiXing; Liu JianYong; Zhang JiCai; Chen Hong; Huang BiZhi; Lei ChuZhao
Publisher
MDPI AG, Basel, Switzerland
Citation
Animals, 2019, 9, 12, pp 1027
Abstract

Copy number variation (CNV) related to complex traits, such as disease and quantitative phenotype, is considered an important and wealthy source of genetic and phenotypic diversity. It suggests that the copy number variation of function gene maybe leads to the phenotypic changes. Kupple like factor ...

Author(s)
Xu JiaWei; Zheng Li; Li LiJuan; Yao YuFei; Hua He; Yang ShiZhen; Wen YiFan; Song ChengChuang; Cao XiuKai; Liu KunPeng; Zhang GuiMin; Yang JiaMeng; Hao Dan; Dang RuiHua; Lan XianYong; Lei ChuZhao; Qi XingLei; Chen Hong; Huang YongZhen
Publisher
Elsevier Ltd, Oxford, UK
Citation
Gene, 2019, 680, pp 99-104
Abstract

Copy number variation (CNV) of DNA sequences, functionally significant but yet fully ascertained, is believed to confer considerable increments in unexplained heritability of quantitative traits. Identification of phenotype-associated CNVs (paCNVs) therefore is a pressing need in CNV studies to...

Author(s)
Cao XiuKai; Huang YongZhen; Ma YiLei; Cheng Jie; Qu ZhenXian; Ma Yun; Bai YueYu; Tian Feng; Lin FengPeng; Ma YuLin; Chen Hong
Publisher
Springer Berlin, Heidelberg, Germany
Citation
Functional & Integrative Genomics, 2018, 18, 5, pp 559-567
Abstract

Copy number variations (CNVs) recently have been recognized as another important genetic variability followed single nucleotide polymorphisms (SNPs). The guanylate binding protein 2 (GBP2) gene plays an important role in cell proliferation. This study was performed to determine the presence of GBP2 ...

Author(s)
Zhang GuiMin; Zheng Li; He Hua; Song ChengChuang; Zhang ZiJing; Cao XiuKai; Lei ChuZhao; Lan XianYong; Qi XingLei; Chen Hong; Huang YongZhen
Publisher
Elsevier Ltd, Oxford, UK
Citation
Gene, 2018, 647, pp 101-106
Abstract

Background: Copy number variation (CNV) is an important type of genetic variation contributing to phenotypic differences among mammals and may serve as an alternative molecular marker to single nucleotide polymorphism (SNP) for genome-wide association study (GWAS). Recently, GWAS analysis using CNV ...

Author(s)
Zhou Yang; Connor, E. E.; Wiggans, G. R.; Lu YongFang; Tempelman, R. J.; Schroeder, S. G.; Chen Hong; Liu, G. E.
Publisher
BioMed Central Ltd, London, UK
Citation
BMC Genomics, 2018, 19, 314, pp (2 May 2018)
Abstract

Whole-genome sequencing provides a powerful tool to obtain more genetic variability that could produce a range of benefits for cattle breeding industry. Nanyang (Bos indicus) and Qinchuan (Bos taurus) are two important Chinese indigenous cattle breeds with distinct phenotypes. To identify the...

Author(s)
Xu Yao; Jiang Yu; Shi Tao; Cai HanFang; Lan XianYong; Zhao Xin; Plath, M.; Chen Hong
Publisher
Public Library of Sciences (PLoS), San Francisco, USA
Citation
PLoS ONE, 2017, 12, 8, pp e0183921

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