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VetMed Resource

Veterinary information to support practice, based on evidence and continuing education

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Abstract

Doramectin, 25-cyclohexyl-5-O-demethyl-25-de(1-methylpropyl)avermectin A1a, was selected as the best of a series of novel avermectins prepared by mutational biosynthesis. The primary evaluation of its in vivo antiparasitic activity was carried out using a rat Trichostrongylus colubriformis model...

Author(s)
Goudie, A. C.; Evans, N. A.; Gration, K. A. F.; Bishop, B. F.; Gibson, S. P.; Holdom, K. S.; Kaye, B.; Wicks, S. R.; Lewis, D.; Weatherley, A. J.; Bruce, C. I.; Herbert, A.; Seymour, D. J.
Citation
Veterinary Parasitology, 1993, 49, 1, pp 5-15
Abstract

The pharmacokinetics of doramectin, a novel avermectin, were evaluated following parenteral administration to calves in a range of oil-based formulations in an attempt to optimize the formulation. Therapeutic and persistent efficacies against Cooperia oncophora in cattle were also evaluated. This...

Author(s)
Wicks, S. R.; Kaye, B.; Weatherley, A. J.; Lewis, D.; Davison, E.; Gibson, S. P.; Smith, D. G.
Citation
Veterinary Parasitology, 1993, 49, 1, pp 17-26
Abstract

Two studies were conducted in Idaho and North Carolina, USA, to evaluate the persistent efficacy of doramectin injectable solution against experimental challenge with infective larvae of Ostertagia ostertagi. In both studies, 4 groups of 10 randomly-assigned calves, negative for...

Author(s)
Conder, G. A.; Cruthers, L. R.; Slone, R. L.; Johnson, E. G.; Zimmerman, G. L.; Zimmerman, L. A.; Shively, J. E.; Logan, N. B.; Weatherley, A. J.
Citation
Veterinary Parasitology, 1997, 72, 1, pp 9-13

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