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VetMed Resource

Veterinary information to support practice, based on evidence and continuing education

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Abstract

Doramectin, 25-cyclohexyl-5-O-demethyl-25-de(1-methylpropyl)avermectin A1a, was selected as the best of a series of novel avermectins prepared by mutational biosynthesis. The primary evaluation of its in vivo antiparasitic activity was carried out using a rat Trichostrongylus colubriformis model...

Author(s)
Goudie, A. C.; Evans, N. A.; Gration, K. A. F.; Bishop, B. F.; Gibson, S. P.; Holdom, K. S.; Kaye, B.; Wicks, S. R.; Lewis, D.; Weatherley, A. J.; Bruce, C. I.; Herbert, A.; Seymour, D. J.
Citation
Veterinary Parasitology, 1993, 49, 1, pp 5-15
Abstract

The pharmacokinetics of doramectin, a novel avermectin, were evaluated following parenteral administration to calves in a range of oil-based formulations in an attempt to optimize the formulation. Therapeutic and persistent efficacies against Cooperia oncophora in cattle were also evaluated. This...

Author(s)
Wicks, S. R.; Kaye, B.; Weatherley, A. J.; Lewis, D.; Davison, E.; Gibson, S. P.; Smith, D. G.
Citation
Veterinary Parasitology, 1993, 49, 1, pp 17-26