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VetMed Resource

Veterinary information to support practice, based on evidence and continuing education

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Abstract

A total of 40 cattle in Germany harbouring naturally acquired infections of gastrointestinal nematodes, including Ostertagia spp., Oesophagostomum spp. Cooperia spp., Haemonchus spp., Nematodirus spp. and Trichuris spp., were allocated to a treated or a control group (20 animals/group), and 100...

Author(s)
Mehlhorn, H.; Jones, H. L.; Weatherley, A. J.; Schumacher, B.
Citation
Parasitology Research, 1993, 79, 7, pp 603-607
Abstract

Doramectin, 25-cyclohexyl-5-O-demethyl-25-de(1-methylpropyl)avermectin A1a, was selected as the best of a series of novel avermectins prepared by mutational biosynthesis. The primary evaluation of its in vivo antiparasitic activity was carried out using a rat Trichostrongylus colubriformis model...

Author(s)
Goudie, A. C.; Evans, N. A.; Gration, K. A. F.; Bishop, B. F.; Gibson, S. P.; Holdom, K. S.; Kaye, B.; Wicks, S. R.; Lewis, D.; Weatherley, A. J.; Bruce, C. I.; Herbert, A.; Seymour, D. J.
Citation
Veterinary Parasitology, 1993, 49, 1, pp 5-15
Abstract

The pharmacokinetics of doramectin, a novel avermectin, were evaluated following parenteral administration to calves in a range of oil-based formulations in an attempt to optimize the formulation. Therapeutic and persistent efficacies against Cooperia oncophora in cattle were also evaluated. This...

Author(s)
Wicks, S. R.; Kaye, B.; Weatherley, A. J.; Lewis, D.; Davison, E.; Gibson, S. P.; Smith, D. G.
Citation
Veterinary Parasitology, 1993, 49, 1, pp 17-26
Abstract

A series of 28 controlled anthelmintic studies, involving 634 cattle, was conducted throughout North America and Europe to evaluate the efficacy of doramectin against a broad range of gastrointestinal parasitic nematode species and lungworms in naturally and experimentally infected animals. Within...

Author(s)
Jones, R. M.; Logan, N. B.; Weatherley, A. J.; Little, A. S.; Smothers, C. D.
Citation
Veterinary Parasitology, 1993, 49, 1, pp 27-37
Abstract

Three studies were conducted involving cattle exposed to experimental nematode infections. These studies were designed to investigate the prophylactic activity of a single s.c. treatment of doramectin at 200 µg/kg bwt against infections of Ostertagia ostertagi, Cooperia oncophora and Dictyocaulus...

Author(s)
Weatherley, A. J.; Hong, C.; Harris, T. J.; Smith, D. G.; Hammet, N. C.
Citation
Veterinary Parasitology, 1993, 49, 1, pp 45-50
Abstract

Two studies were performed to investigate the efficacy of doramectin in the prevention of infection with Ostertagia ostertagi and Cooperia oncophora in grazing calves. In each study 24 parasite-naive calves were randomly allotted to 2 equal groups and treated with either doramectin at 200 µg/kg or...

Author(s)
Vercruysse, J.; Dorny, P.; Hong, C.; Harris, T. J.; Hammet, N. C.; Smith, D. G.; Weatherley, A. J.
Citation
Veterinary Parasitology, 1993, 49, 1, pp 51-59

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