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Abstract

Cysteine proteinase enriched fractions obtained by thiol-sepharose chromatography of O. ostertagi membrane-bound protein extract (S3-thiol) or total adult excretory-secretory (ES-thiol) products were tested in a vaccination experiment to evaluate their protective efficacy against O. ostertagi in ...

Author(s)
Geldhof, P.; Claerebout, E.; Knox, D.; Vercauteren, I.; Looszova, A.; Vercruysse, J.
Publisher
Blackwell Science, Oxford, UK
Citation
Parasite Immunology, 2002, 24, 5, pp 263-270
Abstract

As an alternative to antihelminthic drugs, we are exploiting vaccination to control infections with the abomasal nematode Ostertagia ostertagi in cattle. Our focus for vaccine targets is excretory-secretory (ES) products of this parasite. One of the most abundant antigens in larval and adult ...

Author(s)
Vercauteren, I.; Geldhof, P.; Vercruysse, J.; Peelaers, I.; Broeck, W. van den; Gevaert, K.; Claerebout, E.
Publisher
American Society for Microbiology (ASM), Washington, USA
Citation
Infection and Immunity, 2004, 72, 5, pp 2995-3001
Abstract

Intramuscular immunization of calves with an excretory-secretory antigen fraction enriched for cysteine proteinase activity (ES-thiol) and QuilA as adjuvant induces a protective immune response against the abomasal nematode Ostertagia ostertagi. A study was conducted to confirm the protective...

Author(s)
Geldhof, P.; Vercauteren, I.; Vercruysse, J.; Knox, D. P.; Broeck, W. van den; Claerebout, E.
Publisher
Blackwell Publishing, Oxford, UK
Citation
Parasite Immunology, 2004, 26, 1, pp 37-43
Abstract

The protective capacity of an adult stage Ostertagia ostertagi globin antigen was tested in four vaccination experiments in cattle. In a preliminary experiment, calves were vaccinated three times intraperitoneally with 250 µg globin in Freund's adjuvant and challenged with a trickled infection of...

Author(s)
Claerebout, E.; Smith, W. D.; Pettit, D.; Geldhof, P.; Raes, S.; Geurden, T.; Vercruysse, J.
Publisher
Elsevier, Amsterdam, Netherlands
Citation
Veterinary Parasitology, 2005, 128, 3/4, pp 299-307
Abstract

Protease inhibitors are thought to protect intestinal parasitic nematodes from their hostile proteolytic environment. In a previous study, screening of Ostertagia ostertagi cDNA libraries with local antibody probes of the abomasal lymph nodes and mucus revealed a (28 kDa) aspartyl protease...

Author(s)
Maere, V. de; Vercauteren, I.; Gevaert, K.; Vercruysse, J.; Claerebout, E.
Publisher
Elsevier, Oxford, UK
Citation
Molecular and Biochemical Parasitology, 2005, 141, 1, pp 81-88
Abstract

The objective of this study was to evaluate abomasal cytokine responses in helminth-naive calves and calves vaccinated with protective antigen fractions from Ostertagia ostertagi after an experimental challenge infection with infective third stage (L3) larvae. Abomasal lymph nodes and/or abomasal...

Author(s)
Claerebout, E.; Vercauteren, I.; Geldhof, P.; Olbrechts, A.; Zarlenga, D. S.; Goddeeris, B. M.; Vercruysse, J.
Publisher
Blackwell Publishing, Oxford, UK
Citation
Parasite Immunology, 2005, 27, 9, pp 325-331
Abstract

Previous vaccination trials against Ostertagia ostertagi in cattle have demonstrated the protective capacity of a protein fraction termed ES-thiol, which is enriched for activation-associated secreted proteins (ASPs) and cysteine proteases. In this study, ES-thiol was subfractionated through...

Author(s)
Meyvis, Y.; Geldhof, P.; Gevaert, K.; Timmerman, E.; Vercruysse, J.; Claerebout, E.
Publisher
Elsevier, Amsterdam, Netherlands
Citation
Veterinary Parasitology, 2007, 149, 3/4, pp 239-245
Abstract

Previous vaccination trials against the economically important cattle parasite Ostertagia ostertagi have indicated the protective capacity of activation-associated secreted proteins (ASPs). The further development of these antigens into a commercial vaccine will require their recombinant...

Author(s)
Geldhof, P.; Meyvis, Y.; Vercruysse, J.; Claerebout, E.
Publisher
Blackwell Publishing, Oxford, UK
Citation
Parasite Immunology, 2008, 30, 1, pp 57-60
Abstract

Nematode infections modulate the immune reaction of humans and livestock and may impair immune responses to non-parasitic antigens such as those present in vaccines. In this study, the relationship between antibodies directed against Ostertagia ostertagi, the economically most important nematode...

Author(s)
Charlier, J.; Forbes, A.; Gucht, S. van; Duchateau, L.; Goddeeris, B. M.; Vercruysse, J.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Research in Veterinary Science, 2013, 95, 3, pp 1055-1058

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