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Abstract

The purpose was to determine the safety and achievable serum concentrations of transdermally administered phenobarbital in healthy cats. The hypothesis was that transdermal phenobarbital would achieve therapeutic serum concentrations (15-45 µg/mL) with minimal short-term adverse effects. Enrolled ...

Author(s)
Krull, D. P.; Thomovsky, S. A.; Chen, A. V.; Mealey, K. L.; Papich, M. G.
Publisher
American Animal Hospital Association, Denver, USA
Citation
Journal of the American Animal Hospital Association, 2019, 55, 1, pp 1-7
Abstract

Objectives: The aim of this study was to compare serum phenobarbital concentrations, adverse events and client satisfaction during 14 weeks of transdermal vs oral phenobarbital administration to epileptic cats. Methods: This was a prospective, fixed-order, crossover pilot study. Nine client-owned ...

Author(s)
Heller, H. L. B.; Trepanier, L. A.; Robertson, M.; Mei ChaoQun
Publisher
Sage Publications, Thousand Oaks, USA
Citation
Journal of Feline Medicine and Surgery, 2019, 21, 12, pp 1181-1187
Abstract

Objectives: Currently, there are no published randomised, controlled veterinary trials evaluating the efficacy of antiepileptic medication in the treatment of myoclonic seizures. Myoclonic seizures are a hallmark of feline audiogenic seizures (FARS). Methods: This prospective, randomised,...

Author(s)
Lowrie, M.; Thomson, S.; Bessant, C.; Sparkes, A.; Harvey, R. J.; Garosi, L.
Publisher
Sage Publications, Thousand Oaks, USA
Citation
Journal of Feline Medicine and Surgery, 2017, 19, 2, pp 200-206
Abstract

Case summary: A 3-year-old spayed female domestic shorthair cat developed a fever 1 week after starting the anticonvulsant phenobarbital. A diagnostic work-up for seizures and subsequent onset of fever of unknown origin, consisting of MRI of the brain, cerebrospinal fluid analysis and infectious...

Author(s)
Djani, D. M.; Draper, W. E.
Publisher
Sage Publications Ltd, London, UK
Citation
Journal of Feline Medicine and Surgery Open Reports, 2019, 5, 1, pp 7-2055116919830214
Abstract

The management of phenobarbital overdose using hemodialysis in a cat with suspected portosystemic shunt is described. An 8 year old British blue intact male cat was referred due to convulsions and stupor. The cat had a lifelong history of abnormal behavior and convulsions every approximately 6...

Author(s)
Klainbart, S.; Kuzi, S.; Segev, G.
Publisher
Israel Veterinary Medical Association, Raanana, Israel
Citation
Israel Journal of Veterinary Medicine, 2017, 72, 3, pp 42-45
Abstract

CASE DESCRIPTION: A 2-year-old neutered male domestic shorthair cat was evaluated for sudden onset of cluster seizures. CLINICAL FINDINGS: At an emergency clinic, the cat had hyperimmunoglobulinemia and thrombocytopenia. On referral, treatment with levetiracetam, zonisamide, and phenobarbital...

Author(s)
Collinet, A.; Sammut, V.
Publisher
American Veterinary Medical Association, Schaumburg, USA
Citation
Journal of the American Veterinary Medical Association, 2017, 251, 12, pp 1457-1461
Abstract

Objectives: The effectiveness of zonisamide (ZNS) against spontaneous epilepsy in cats has not yet been described. The purpose of this study was to investigate the effect of ZNS on interictal paroxysmal discharges (PDs) using scalp electroencephalography (EEG) in familial spontaneous epileptic cats ...

Author(s)
Ukai, M.; Hamamoto, Y.; Yu, Y.; Fujiwara-Igarashi, A.; Fujita, M.; Hasegawa, D.
Publisher
Sage Publications, Thousand Oaks, USA
Citation
Journal of Feline Medicine and Surgery, 2018, 20, 10, pp 962-967
Abstract

A two-year-old female spayed domestic shorthair cat was presented with apathy, inappetence and generalised lymphadenomegaly. Anamnestic data included a generalised seizure disorder and phenobarbital treatment started one month before presentation. Routine blood analysis revealed only mild...

Author(s)
Lieser, J.; Schwedes, C. S.
Publisher
Wiley, Oxford, UK
Citation
Journal of Small Animal Practice, 2018, 59, 7, pp 444-447
Abstract

Case series summary: This was a retrospective study on the clinical features and response to treatment in seven cats with feline hyperaesthesia syndrome (FHS) and tail mutilation. FHS is a poorly understood disorder characterised by skin rippling over the dorsal lumbar area, episodes of jumping and ...

Author(s)
Batle, P. A.; Rusbridge, C.; Nuttall, T.; Heath, S.; Marioni-Henry, K.
Publisher
Sage Publications, Thousand Oaks, USA
Citation
Journal of Feline Medicine and Surgery, 2019, 21, 2, pp 178-185
Abstract

Phenobarbital (PB) decreases the cyclosporine (CsA) blood level in humans. However, the interaction of PB with CsA has not been reported in cats. This study investigated the effects of multiple doses of PB on the pharmacokinetics of CsA in three healthy cats. The treatments included oral CsA 5...

Author(s)
Hoshino, Y.; Inden, T.; Otaka, R.; Fukui, D.; Satoh, H.; Katayama, M.
Publisher
Japanese Society of Veterinary Science, Tokyo, Japan
Citation
Journal of Veterinary Medical Science, 2019, 81, 11, pp 1621-1623

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