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Abstract

Case summary: A female neutered domestic longhair cat, aged 1 year and 5 months, presented with lymphadenomegaly and anaemia following therapy with phenobarbital for idiopathic epilepsy. Physical examination revealed pale pink mucous membranes and peripheral lymphadenomegaly. Haematology showed a...

Author(s)
Walton-Clark, M.; Travail, V.; Best, M.
Publisher
Sage Publications Ltd, London, UK
Citation
Journal of Feline Medicine and Surgery Open Reports, 2022, 8, 1,
Abstract

The purpose was to determine the safety and achievable serum concentrations of transdermally administered phenobarbital in healthy cats. The hypothesis was that transdermal phenobarbital would achieve therapeutic serum concentrations (15-45 µg/mL) with minimal short-term adverse effects. Enrolled ...

Author(s)
Krull, D. P.; Thomovsky, S. A.; Chen, A. V.; Mealey, K. L.; Papich, M. G.
Publisher
American Animal Hospital Association, Denver, USA
Citation
Journal of the American Animal Hospital Association, 2019, 55, 1, pp 1-7
Abstract

A 6-year-old, vaccinated, male neutered domestic shorthair cat was presented due to polyphagia and hypersexuality manifested since he had been adopted one year prior. Clinical and neurological examination was unremarkable, including absence of scrotal testicles and penile spines, indicative of...

Author(s)
Liatis, T.; Cherubini, G. B.
Publisher
Elsevier, New York, USA
Citation
Journal of Veterinary Behavior: Clinical Applications and Research, 2021, 41, pp 7-11
Abstract

Case summary: A 3-year-old neutered male domestic shorthair cat developed pancytopenia 6 months after starting phenobarbital for treatment of recurrent seizures. The cat was switched from phenobarbital to levetiracetam and complete resolution of the pancytopenia was documented within 10 weeks,...

Author(s)
Lyraki, M.; Wilson, H.
Publisher
Sage Publications Ltd, London, UK
Citation
Journal of Feline Medicine and Surgery Open Reports, 2020, 6, 1, pp 20-2055116920916945
Abstract

Oral therapy can be challenging for cats and owners. We report the development and application of a phenobarbital preparation that can be used at home for longterm transdermal therapy in epileptic cats. A compounded transdermal 12.5% phenobarbital gel can be easily applied to the feline pinna...

Author(s)
Majercikova, R.; Wambacher, M.; Liebhart, A.; Luckschander-Zeller, N.; Leschnik, M.; Pakozdy, A.
Publisher
Gröbner GmbH, Oberwart, Austria
Citation
Wiener Tierärztliche Monatsschrift, 2020, 107, 3/4, pp 72-78
Abstract

Objectives: Phenobarbital (PB) is the most common antiseizure drug (ASD) used for the management of feline epilepsy. In dogs, PB is known to cause serum liver enzyme induction and hepatotoxicity, especially after administration long term or in high concentrations. In cats, insufficient evidence is...

Author(s)
Hermans, M.; Charalambous, M.; Serrano, G.; Cornelis, I.; Luc Van Ham; Paepe, D.; Bhatti, S. F.; Pakozdy, A.; Eisl-Glantschnigg, U.; Neßler, J.; Meervenne, S. A. van; Broeckx, B. J. G.
Publisher
Sage Publications, Thousand Oaks, USA
Citation
Journal of Feline Medicine and Surgery, 2022, 24, 6, pp 530-538
Abstract

Objectives: The aim of this study was to compare serum phenobarbital concentrations, adverse events and client satisfaction during 14 weeks of transdermal vs oral phenobarbital administration to epileptic cats. Methods: This was a prospective, fixed-order, crossover pilot study. Nine client-owned ...

Author(s)
Heller, H. L. B.; Trepanier, L. A.; Robertson, M.; Mei ChaoQun
Publisher
Sage Publications, Thousand Oaks, USA
Citation
Journal of Feline Medicine and Surgery, 2019, 21, 12, pp 1181-1187
Abstract

A six-month-old, uncastrated, male American shorthair cat was diagnosed with most likely primary epilepsy by history, laboratory examination and MRI. After 10 days of treatment with phenobarbital and levetiracetam, the cat developed inappetence and generalised lymphadenopathy. Cytological...

Author(s)
Chen SiYu; Peng YuJia; Xia ZhaoFei; Li GeBin
Publisher
BMJ Publishing Group, London, UK
Citation
Veterinary Record Case Reports, 2020, 8, 4,
Abstract

The management of phenobarbital overdose using hemodialysis in a cat with suspected portosystemic shunt is described. An 8 year old British blue intact male cat was referred due to convulsions and stupor. The cat had a lifelong history of abnormal behavior and convulsions every approximately 6...

Author(s)
Klainbart, S.; Kuzi, S.; Segev, G.
Publisher
Israel Veterinary Medical Association, Raanana, Israel
Citation
Israel Journal of Veterinary Medicine, 2017, 72, 3, pp 42-45
Abstract

Case summary: A 3-year-old spayed female domestic shorthair cat developed a fever 1 week after starting the anticonvulsant phenobarbital. A diagnostic work-up for seizures and subsequent onset of fever of unknown origin, consisting of MRI of the brain, cerebrospinal fluid analysis and infectious...

Author(s)
Djani, D. M.; Draper, W. E.
Publisher
Sage Publications Ltd, London, UK
Citation
Journal of Feline Medicine and Surgery Open Reports, 2019, 5, 1, pp 7-2055116919830214

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