Objective: To estimate the pharmacokinetics of midazolam and 1-hydroxymidazolam after midazolam administration as an intravenous bolus in sevoflurane-anesthetized cats. Study design: Prospective pharmacokinetic study. Animals: A group of six healthy adult, female domestic cats. Methods: Anesthesia...

The aim of this study was to compare the effects of midazolam-ketamine alone or in combination with dexmedetomidine or tramadol in a constant rate infusion (CRI) on the minimum infusion rate (MIR) of propofol and the cardiorespiratory function in cats undergoing an ovariohysterectomy (OH). This was ...

Two healthy research cats involved in a randomized, blinded prospective pharmacodynamics study evaluating midazolam continuous-rate infusion as a means to decrease sevoflurane concentrations experienced unexpectedly prolonged recoveries. Midazolam loading doses, infusion rates, and the targeted...

Pethidine is a synthetic opioid that is widely used in cats. However, the sedative, cardiorespiratory, and histaminic effects following administration of pethidine with midazolam in cats remain unclear. The objectives of this study were to evaluate and compare changes before and after intravenous...

Objective: To investigate the median effective dose 50 (ED₅₀) of midazolam required for endotracheal intubation when used for co-induction of anesthesia with a low dose of alfaxalone in sedated cats. Study design: Randomized up-and-down study. Animals: A group of 14 mixed-breed cats (eight males,...

This study aimed to elucidate whether midazolam affected the learning and memory of rats through the extracellular signalregulated kinase (ERK)/cyclic adenosine monophosphate response element-binding (CREB) signaling pathway and hippocampal oxidative damage. Overall 120 Wistar rats were randomly...

This study examined the post-operative effects of atipamezole (Ati) and flumazenil (Flu) on stress-related neurohormonal and metabolic responses in isoflurane-anesthetized cats premedicated with medetomidine, midazolam and ketamine and undergoing ovariohysterectomy or castration. Client-owned...

Objectives: The aim of this pilot study was to compare the quality of sedation and ease of intravenous (IV) catheter placement following sedation using two intramuscular (IM) sedation protocols in cats: hydromorphone, alfaxalone and midazolam vs hydromorphone and alfaxalone. Methods: This was a...

The efficacy, safety, physiologic effects, and reversibility of butorphanol-medetomidine-midazolam (BMM) immobilization were evaluated in black-footed cats (Felis nigripes) and compared between captive and wild animals. Nine captive and 14 wild black-footed cats were hand injected into an...

The aim of this clinical trial was to evaluate the impacts of administration via the intrarectal route (IR) in cats on their heart and respiratory rates, blood pressure, body temperature, and sedation quality compared to the intramuscular route (IM). The intramuscular group (IMG) received 0.003 mg...