Background: Multimodal analgesia consists of the combination of analgesic drugs at low doses to act in different places along the path of pain. Studies with continuous infusion of analgesic drugs in cats are not common. This study aimed to evaluate the analgesic effect of maropitant, lidocaine and...

Maropitant is a neurokinin-1 (NK1) receptor antagonist that can be used for pain management. The objective of this study was to evaluate the effect of continuous infusion of two doses of maropitant on cardiorespiratory parameters and its postoperative analgesic effect in cats undergoing...

Objectives: The aim of this study was to investigate the antiemetic, behavioural and physiological effects of oral maropitant treatment before the administration of brimonidine ophthalmic solution in healthy cats. Methods: Five cats received oral maropitant 8 mg or no treatment (control) 18 h...

Pain is a complex multifactorial experience associated with tissue damage that causes suffering and reduces an animal's quality of life. Maropitant citrate is a antagonist specific to the NK-1 receptor which selectively inhibits the production of substance P, a mediator involved in the signals...

The primary goal of this retrospective study was to evaluate the effect of postoperative appetite return in cats premedicated with maropitant citrate. Medical records of 75 cats admitted for gastrointestinal (GI) and urogenital (UG) surgeries were reviewed and analyzed. Buprenorphine analgesia was...

OBJECTIVE: To evaluate the effects of maropitant in cats receiving dexmedetomidine and morphine. DESIGN: Randomized controlled trial. ANIMALS: 66 healthy female domestic shorthair cats. PROCEDURES: Cats were randomly assigned to receive maropitant (1 mg/kg [0.45 mg/lb], SC; maropitant group; n=32)...

Objectives: The main goal of this study was to test the antiemetic effects of maropitant administered orally 2-2.5 h prior to morphine and dexmedetomidine in cats. Methods: Eighty-three healthy female cats were randomized to receive maropitant (8 mg orally; n=39) or no treatment (control; n=44),...

The neurokinin-1 (NK-1) receptor antagonist, maropitant citrate, mitigates nausea and vomiting in dogs and cats. Nausea is poorly understood in horses, and clinical use of NK-1 receptor antagonists has not been reported. This study aimed to determine the pharmacokinetics and safety of maropitant...

Maropitant citrate is a synthetic neurokinin-1 receptor antagonist and substance P inhibitor used for control of emesis in dogs in cats. Maropitant citrate is used empirically in birds, despite a lack of pharmacokinetic data in avian species. The objective of this study was to determine the...

The neurokinin-1 (NK) receptor antagonist, maropitant citrate, mitigates nausea and vomiting in dogs and cats. Nausea is poorly understood and likely under-recognized in horses. Use of NK-1 receptor antagonists in horses has not been reported. The purpose of this study was to determine the...