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Abstract

Maropitant is a neurokinin-1 (NK1) receptor antagonist that can be used for pain management. The objective of this study was to evaluate the effect of continuous infusion of two doses of maropitant on cardiorespiratory parameters and its postoperative analgesic effect in cats undergoing...

Author(s)
Corrêa, J. X.; Soares, P. C. L. R.; Niella, R. V.; Costa, B. A.; Ferreira, M. S.; Silva Junior, A. C.; Sena, A. S.; Sampaio, K. O. R.; Silva, E. B.; Silva, F. L.; Lavor, M. S. L.
Publisher
Hindawi, London, UK
Citation
Veterinary Medicine International, 2019, 2019, 9352528,
Abstract

Objectives: The aim of this study was to investigate the antiemetic, behavioural and physiological effects of oral maropitant treatment before the administration of brimonidine ophthalmic solution in healthy cats. Methods: Five cats received oral maropitant 8 mg or no treatment (control) 18 h...

Author(s)
Kanda, T.; Toda, C.; Morimoto, H.; Shimizu, Y.; Itoi, T.; Furumoto, K.; Iwata, E.; Okamura, Y.
Publisher
Sage Publications, Thousand Oaks, USA
Citation
Journal of Feline Medicine and Surgery, 2020, 22, 6, pp 557-563
Abstract

Objectives: The main goal of this study was to test the antiemetic effects of maropitant administered orally 2-2.5 h prior to morphine and dexmedetomidine in cats. Methods: Eighty-three healthy female cats were randomized to receive maropitant (8 mg orally; n=39) or no treatment (control; n=44),...

Author(s)
Martin-Flores, M.; Mastrocco, A.; Lorenzutti, A. M.; Campoy, L.; Kirch, P.; Stone, M.; Learn, M. M.; Boesch, J. M.
Publisher
Sage Publications, Thousand Oaks, USA
Citation
Journal of Feline Medicine and Surgery, 2017, 19, 8, pp 876-879
Abstract

OBJECTIVE: To evaluate the effects of maropitant in cats receiving dexmedetomidine and morphine. DESIGN: Randomized controlled trial. ANIMALS: 66 healthy female domestic shorthair cats. PROCEDURES: Cats were randomly assigned to receive maropitant (1 mg/kg [0.45 mg/lb], SC; maropitant group; n=32)...

Author(s)
Martin-Flores, M.; Sakai, D. M.; Learn, M. M.; Mastrocco, A.; Campoy, L.; Boesch, J. M.; Gleed, R. D.
Publisher
American Veterinary Medical Association, Schaumburg, USA
Citation
Journal of the American Veterinary Medical Association, 2016, 248, 11, pp 1257-1261
Abstract

The neurokinin-1 (NK-1) receptor antagonist, maropitant citrate, mitigates nausea and vomiting in dogs and cats. Nausea is poorly understood in horses, and clinical use of NK-1 receptor antagonists has not been reported. This study aimed to determine the pharmacokinetics and safety of maropitant...

Author(s)
Berryhill, E. H.; Knych, H.; Chigerwe, M.; Edman, J.; Magdesian, K. G.
Publisher
Wiley, Oxford, UK
Citation
Journal of Veterinary Pharmacology and Therapeutics, 2020, 43, 3, pp 282-287
Abstract

The neurotransmitter Substance P, and its neurokinin-1 receptor (NK-1R) are involved in the regulation of many pathophysiological processes including emesis, inflammation and nociceptive processing. This review provides a brief summary of the anti-inflammatory and analgesic properties of...

Author(s)
Kinobe, R. T.; Miyake, Y.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Veterinary Journal, 2020, 259/260,
Abstract

The neurokinin-1 (NK) receptor antagonist, maropitant citrate, mitigates nausea and vomiting in dogs and cats. Nausea is poorly understood and likely under-recognized in horses. Use of NK-1 receptor antagonists in horses has not been reported. The purpose of this study was to determine the...

Author(s)
Berryhill, E. H.; Knych, H.; Edman, J. M.; Magdesian, K. G.
Publisher
Wiley, Oxford, UK
Citation
Journal of Veterinary Pharmacology and Therapeutics, 2019, 42, 4, pp 487-491
Abstract

Objectives: Non-flea, non-food-induced hypersensitivity dermatitis (NFNFIHD) is a common inflammatory and pruritic skin disease in cats. When avoidance and conventional systemic immunosuppressive treatments fail to control the clinical signs, there are limited treatment options. The aim of this...

Author(s)
Maina, E.; Fontaine, J.
Publisher
Sage Publications, Thousand Oaks, USA
Citation
Journal of Feline Medicine and Surgery, 2019, 21, 10, pp 967-972
Abstract

Objectives: Maropitant is commonly used for acute vomiting. A pharmacokinetic and toxicity study in cats indicated that longer term usage appears safe. The aim of this study was to assess the efficacy of maropitant for management of chronic vomiting and inappetence associated with feline chronic...

Author(s)
Quimby, J. M.; Brock, W. T.; Moses, K.; Bolotin, D.; Patricelli, K.
Publisher
Sage Publications, Thousand Oaks, USA
Citation
Journal of Feline Medicine and Surgery, 2015, 17, 8, pp 692-697
Abstract

Neurokinin-1 (NK-1) receptors are present in both the central nervous system and peripheral tissues. Substance P (SP) is the major ligand and is involved in multiple processes including pain transmission, vasodilation, modulation of the inflammatory response, as well as the sensory neuronal...

Author(s)
Kraus, B. L. H.
Publisher
Dove Medical Press Ltd, Macclesfield, UK
Citation
Veterinary Medicine: Research and Reports, 2017, 8, pp 41-51

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