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VetMed Resource

Veterinary information to support practice, based on evidence and continuing education

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Abstract

OBJECTIVE: To evaluate safety and toxicokinetic profiles associated with daily oral administration of grapiprant, a new analgesic that selectively blocks the prostaglandin E2 EP4 receptor, to cats. ANIMALS: 24 healthy domestic shorthair cats (12 males and 12 females). PROCEDURES: Cats were randomly ...

Author(s)
Rausch-Derra, L. C.; Rhodes, L.
Publisher
American Veterinary Medical Association, Schaumburg, USA
Citation
American Journal of Veterinary Research, 2016, 77, 7, pp 688-692
Abstract

Drugs that provide effective analgesia in cats are limited. The aim of the study was to assess the pharmacokinetics of grapiprant after 2 mg/kg administration via p.o. and i.v. routes in cats. Six healthy adult cats were used according to an open, single-dose, two-treatment, two-period, randomized...

Author(s)
Lebkowska-Wieruszewska, B.; Vito, V. de; Owen, H.; Poapholatep, A.; Giorgi, M.
Publisher
Wiley, Oxford, UK
Citation
Journal of Veterinary Pharmacology and Therapeutics, 2017, 40, 6, pp e11-e15
Abstract

There are five active prostanoid metabolites of arachidonic acid (AA) that have widespread and varied physiologic functions throughout the body, including regulation of gastrointestinal mucosal blood flow, renal haemodynamics and primary haemostasis. Each prostanoid has at least one distinct...

Author(s)
Shaw, K. K.; Rausch-Derra, L. C.; Rhodes, L.
Publisher
Wiley-Blackwell, Oxford, UK
Citation
Veterinary Medicine and Science, 2016, 2, 1, pp 3-9