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Abstract

Clomipramine is a tricyclic antidepressant (TCA) commonly used to treat anxiety related behavioral disorders in companion animals. Tricyclic antidepressants (TCAs) have the potential to cause arrhythmias in humans and companion animals. The effect of the TCAs, clomipramine, and amitriptyline, at...

Author(s)
Martin, K. M.
Publisher
Elsevier, New York, USA
Citation
Journal of Veterinary Behavior: Clinical Applications and Research, 2010, 5, 3, pp 123-129
Abstract

In animal health risk assessment, hazard characterisation of feed additives has been often using the default uncertainty factor (UF) of 100 to translate a no-observed-adverse-effect level in test species (rat, mouse, dog, rabbit) to a 'safe' level of chronic exposure in farm and companion animal...

Author(s)
Lautz, L. S.; Jeddi, M. Z.; Girolami, F.; Nebbia, C.; Dorne, J. L. C. M.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Toxicology Letters, 2021, 338, pp 114-127
AbstractFull Text

The present report describes a case of distal tail self-mutilation in a 5-year-old neutered male domestic short-hair cat. The cat started licking his tail few months before the behavioural visit. Because of the severity of the self-induced injuries, the veterinarian performed a surgical partial...

Author(s)
Talamonti, Z.; Cannas, S.; Palestrini, C.
Publisher
Faculty of Veterinary Medicine, University of Ss Cyril and Methodius, Skopje, Republic of Macedonia
Citation
Macedonian Veterinary Review, 2017, 40, 1, pp 103-107
Abstract

A cross-over study was performed in six adult spayed cats to determine the pharmacokinetics of clomipramine and its metabolite, desmethylclomipramine (DCMP) after intravenous (0.25 mg/kg) and oral (0.5 mg/kg) single-dose administrations. Plasma clomipramine and DCMP were measured by...

Author(s)
Lainesse, C.; Frank, D.; Meucci, V.; Intorre, L.; Soldani, G.; Doucet, M.
Publisher
Blackwell Publishing, Oxford, UK
Citation
Journal of Veterinary Pharmacology and Therapeutics, 2006, 29, 4, pp 271-278
Abstract

A double-blind, placebo-controlled clinical trial was conducted to determine the efficacy of clomipramine hydrochloride in cats with psychogenic alopecia. Twenty-five cats were randomly assigned to receive clomipramine hydrochloride (0.5 mg/kg orally q 24 hours) or placebo for 56 days. Eleven cats...

Author(s)
Mertens, P. A.; Torres, S.; Jessen, C.
Publisher
American Animal Hospital Association, Denver, USA
Citation
Journal of the American Animal Hospital Association, 2006, 42, 5, pp 336-343
Abstract

This study was conducted to confirm an interindividual variability in pharmacokinetic parameters of clomipramine in a large population of cats and to identify potential covariables that would explain the presence of such pharmacokinetic variability after a single dose of Clomicalm®. Clomipramine...

Author(s)
Lainesse, C.; Frank, D.; Beaudry, F.; Doucet, M.
Publisher
Blackwell Publishing, Oxford, UK
Citation
Journal of Veterinary Pharmacology and Therapeutics, 2007, 30, 2, pp 116-126
Abstract

Case series summary: This was a retrospective study on the clinical features and response to treatment in seven cats with feline hyperaesthesia syndrome (FHS) and tail mutilation. FHS is a poorly understood disorder characterised by skin rippling over the dorsal lumbar area, episodes of jumping and ...

Author(s)
Batle, P. A.; Rusbridge, C.; Nuttall, T.; Heath, S.; Marioni-Henry, K.
Publisher
Sage Publications, Thousand Oaks, USA
Citation
Journal of Feline Medicine and Surgery, 2019, 21, 2, pp 178-185
Abstract

Objective - To determine the optimal dosage of clomipramine for the treatment of urine spraying in cats. Design - Randomized controlled multicenter clinical trial. Animals - 67 neutered cats. Procedure - Cats with a minimum 1-month history of spraying urine against vertical surfaces at least twice...

Author(s)
King, J. N.; Steffan, J.; Heath, S. E.; Simpson, B. S.; Crowell-Davis, S. L.; Harrington, L. J. M.; Weiss, A. B.; Seewald, W.
Publisher
American Veterinary Medical Association, Schaumburg, USA
Citation
Journal of the American Veterinary Medical Association, 2004, 225, 6, pp 881-887
Abstract

The objectives of this in vitro study were to describe cytochrome-dependent metabolism of clomipramine in canine and feline microsomes, compare metabolic profiles between cats, rats and dogs, and investigate a potential gender-related difference in metabolic activity between male and female cats....

Author(s)
Lainesse, C.; Frank, D.; Beaudry, F.; Doucet, M.
Publisher
Blackwell Publishing, Oxford, UK
Citation
Journal of Veterinary Pharmacology and Therapeutics, 2007, 30, 5, pp 387-393
Abstract

Objectives - To determine whether clomipramine differs from fluoxetine in reducing feline urine marking; whether reduction of marking continues in cats treated >8 weeks; whether recurrence of marking, after abrupt drug withdrawal, is less in cats treated >8 weeks; and whether cats that are...

Author(s)
Hart, B. L.; Cliff, K. D.; Tynes, V. V.; Bergman, L.
Publisher
American Veterinary Medical Association, Schaumburg, USA
Citation
Journal of the American Veterinary Medical Association, 2005, 226, 3, pp 378-382

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