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Abstract

Senecavirus A (SVA) is classified into the genus Senecavirus in the family Picornaviridae. Its genome is a positive-sense, single-stranded and nonsegmented RNA, approximately 7300 nucleotides in length. A picornaviral genome is essentially an mRNA, which, albeit unmodified with 5' cap structure,...

Author(s)
Liu FuXiao; Wang Ning; Huang YiLan; Wang QianQian; Shan Hu
Publisher
Elsevier B.V., Amsterdam, Netherlands
Citation
Veterinary Microbiology, 2021, 255,
Abstract

Senecavirus A (SVA), also known as Seneca Valley virus, belongs to the genus Senecavirus in the family Picornaviridae. In this study, a China SVA isolate (CH-LX-01-2016) was rescued from its cDNA clone, and then identified by RT-PCR, indirect immunofluorescence assay and mass spectrometry. The...

Author(s)
Liu FuXiao; Huang YiLan; Wang QianQian; Li JuAn; Shan Hu
Publisher
Elsevier B.V., Amsterdam, Netherlands
Citation
Veterinary Microbiology, 2021, 253,
Abstract

Synonymous codon bias in the viral genome affects protein translation and gene expression, suggesting that the synonymous codon mutant plays an essential role in influencing virulence and evolution. However, how the recessive mutant form contributes to virus evolvability remains elusive. In this...

Author(s)
Zhao SiMiao; Cui HuiQi; Hu ZhenRu; Du Li; Ran XuHua; Wen XiaoBo
Publisher
MDPI AG, Basel, Switzerland
Citation
Viruses, 2022, 14, 5,
Abstract

Senecavirus A (SVA) is a picornavirus that causes vesicular disease in swine, and the inactivated vaccine is used to prevent and control SVA infection. To develop a new chromatography strategy for the purification and concentration of SVA vaccine antigens, we inserted a 6×His-tag at the VP1...

Author(s)
Fan JunHao; Xiao PeiYu; Kong DongNi; Liu, X.; Meng Liang; An TongQing; Cai XueHui; Wang HaiWei; Yu Li
Publisher
MDPI AG, Basel, Switzerland
Citation
Vaccines, 2022, 10, 2,
Abstract

Senecavirus A (SVA) is an emerging picornavirus associated with porcine idiopathic vesicular disease (PIVD), which is clinically indistinguishable from foot-and-mouth disease and other vesicular diseases in pigs. In recent years, the wide spread of SVA has caused huge economic losses to the world's ...

Author(s)
Li Ning; Qiao QiLong; Guo HuiFang; Wang BaiYu; Huang Qing; Wang Zeng; Li YongTao; Zhao Jun
Publisher
Elsevier Ltd, Oxford, UK
Citation
Research in Veterinary Science, 2022, 142, pp 133-140
Abstract

Senecavirus A (SVA) is a new virus inducing porcine idiopathic vesicular disease that causes significant economic losses. Although some progress has been made in etiological research, the role of host factors in SVA infection remains unclear. This study investigated the role of the host factor,...

Author(s)
Chen YongJie; Zhong WenXia; Xie ZhenXin; Li BaoJian; Li HuiZi; Gao KuiPeng; Ning ZhangYong
Publisher
Elsevier B.V., Amsterdam, Netherlands
Citation
Virus Research, 2022, 313,
Abstract

Senecavirus A (SVA), classified into the genus Senecavirus in the family Picornaviridae, causes an infectious disease in pigs. This virus can efficiently replicate in some non-pig-derived cells, such as the BHK cell line and its derivative (BSR-T7/5 cell line). We had recovered a wild-type SVA from ...

Author(s)
Liu, F.; Ni, B.; Wei, R.
Publisher
Frontiers Media S.A., Lausanne, Switzerland
Citation
Frontiers in Cellular and Infection Microbiology, 2022, 12, January,
Abstract

Foot-and-mouth disease virus (FMDV) is a picornavirus that produces a highly transmissible vesicular disease that can devastate meat and dairy production to such an extent that FMDV-free countries commit significant economic resources to maintain their FMDV-free status. Senecavirus A (SVA), also a...

Author(s)
Buckley, A.; Lager, K.
Publisher
Public Library of Sciences (PLoS), San Francisco, USA
Citation
PLoS ONE, 2022, 17, 4,
Abstract

Senecavirus A (SVA) is a cause of vesicular disease in pigs, and infection rates are rising within the swine industry. Recently, anthrax toxin receptor 1 (ANTXR1) was revealed as the receptor for SVA in human cells. Herein, the role of ANTXR1 as a receptor for SVA in pigs was investigated by...

Author(s)
Chen, P. R.; Rowland, R. R. R.; Stoian, A. M.; Petrovan, V.; Sheahan, M.; Ganta, C.; Cino-Ozuna, G.; Kim DaeYoung; Dunleavey, J. M.; Whitworth, K. M.; Samuel, M. S.; Spate, L. D.; Cecil, R. F.; Benne, J. A.; Yan XingYu; Fang Ying; St. Croix, B.; Lechtenberg, K.; Wells, K. D.; Prather, R. S.
Publisher
Nature Publishing Group, London, UK
Citation
Scientific Reports, 2022, 12, 3,
Abstract

Senecavirus A (SVA), formerly known as Seneca Valley virus, belongs to the genus Senecavirus in the family Picornaviridae. SVA has a single-stranded, positive-sense RNA genome, which is actually an mRNA that initiates translation via its own internal ribosome entry site (IRES). The SVA IRES has...

Author(s)
Liu FuXiao; Wang Qi; Meng HaiLan; Zhao Di; Hao XiaoJing; Zhang ShuRen; Lu JinFeng; Shan Hu
Publisher
Elsevier B.V., Amsterdam, Netherlands
Citation
Veterinary Microbiology, 2022, 271,

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