This study aimed to determine the anesthetic efficacy of intranasal medetomidine/ketamine and diazepam/ketamine combinations in New Zealand White rabbits. For this purpose, 12 adult New Zealand White rabbits weighing 2.3-4.1 kg were used by randomly dividing the animals into two groups of six...

The effect of pentazocine on diazepam/ketamine anaesthesia was evaluated in this study. Pentazocine (10 mg/kg) was administered intramuscularly (im) prior to injection of diazepam (2 mg/kg, iv) and ketamine (15 mg/kg, im) in pentazocine/diazepam/ketamine (P/D/K) group. In the diazepam/ketamine...

The combined effect of microplastics and pharmaceuticals on aquatic organisms is an issue of concern. In this laboratory study, we evaluated the combined effect of polystyrene microplastics (2-μm diameter) and diazepam on the social behavior of medaka (Oryzias latipes) by using the shoaling...

Diazepam-based drugs are widely used today in human treatment. Diazepam may be a primary drug aimed at treating neurological diseases or an associated drug in the treatment of other diseases in the purpose of symptomatic therapy. The sedative effect of diazepam characterizes it as a drug that...

Water hemlocks (Cicuta spp.) are toxic members of the Apiaceae plant family. The best drug treatment for the convulsions associated with acute water hemlock poisoning in livestock and humans has not been determined experimentally. This work compared the therapeutic actions of benzodiazepines (...

The aim of this prospective, randomized, blinded crossover study was compare the cardiopulmonary and sedative effects of ketamine in combination with acepromazine, diazepam, dexmedetomidine, midazolam or xylazine, injected intramuscularly in rabbits, using eight one-year-old male New Zealand ...

Social housing is one of the best forms of environmental enhancement for nonhuman primates, and current research into pair compatibility and introduction techniques focuses on improving safety and outcome. The gradual steps method (GS), which is widely used for introducing indoor-housed macaques,...

PICO question: In healthy dogs, does the use of diazepam or midazolam administered in co-induction with propofol result in a reduction in the dose of propofol required to induce anaesthesia and a decrease in adverse cardiovascular and respiratory events? Clinical bottom line: Category of research...

Main aim of current study was to determine the anxiolytic and antidepressant potential of Bougainvillea glabra Extract (BVE). The effects were investigated by using Open-Field-Test (OFT), Light-and-Dark Model (LD), Hole-Board (HB) and Forced-Swimming-Test (FST). Different doses for BVE were given...

The efficacy and safety of the recommended intramuscular (im) clinical doses of xylazine-ketamine (5 mg-35 mg/kg), diazepam-ketamine (5 mg-60 mg/kg) and acepromazine-ketamine (5 mg-75 mg/kg) post administration were obtained, evaluated and compared using the following parameters in 10 apparently...