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Abstract

In the event of a bioterror attack with variola virus (smallpox), exposure may only be identified following onset of fever. To determine if antiviral therapy with brincidofovir (BCV; CMX001) initiated at, or following, onset of fever could prevent severe illness and death, a lethal rabbitpox model...

Author(s)
Grossi, I. M.; Foster, S. A.; Gainey, M. R.; Krile, R. T.; Dunn, J. A.; Brundage, T.; Khouri, J. M.
Publisher
Elsevier, Amsterdam, Netherlands
Citation
Antiviral Research, 2017, 143, pp 278-286
Abstract

BACKGROUND: Smallpox was declared eradicated in 1980, but variola virus (VARV), which causes smallpox, still exists. There is no known effective treatment for smallpox; therefore, tecovirimat is being developed as an oral smallpox therapy. Because clinical trials in a context of natural disease are ...

Author(s)
Grosenbach, D. W.; Honeychurch, K.; Rose, E. A.; Chinsangaram, J.; Frimm, A.; Maiti, B.; Lovejoy, C.; Meara, I.; Long, P.; Hruby, D. E.
Publisher
Massachusetts Medical Society, Waltham, USA
Citation
New England Journal of Medicine, 2018, 379, 1, pp 44-53
Abstract

Orthopoxviruses, such as variola and monkeypox viruses, can cause severe disease in humans when delivered by the aerosol route, and thus represent significant threats to both military and civilian populations. Currently, there are no antiviral therapies approved by the U.S. Food and Drug...

Author(s)
Nalca, A.; Hatkin, J. M.; Garza, N. L.; Nichols, D. K.; Norris, S. W.; Hruby, D. E.; Jordan, R.
Publisher
Elsevier, Amsterdam, Netherlands
Citation
Antiviral Research, 2008, 79, 2, pp 121-127
Abstract

CMX001, a lipophilic nucleotide analog formed by covalently linking 3-(hexdecyloxy)propan-1-ol to cidofovir (CDV), is being developed as a treatment for smallpox. CMX001 has dramatically increased potency versus CDV against all dsDNA viruses and, in contrast to CDV, is orally available and has...

Author(s)
Rice, A. D.; Adams, M. M.; Lampert, B.; Foster, S.; Lanier, R.; Robertson, A.; Painter, G.; Moyer, R. W.
Publisher
Molecular Diversity Preservation International (MDPI), Basel, Switzerland
Citation
Viruses, 2011, 3, 2, pp 63-82
Abstract

The threat of smallpox release and use as a bioweapon has encouraged the search for new vaccines and antiviral drugs, as well as development of new small-animal models in which their efficacy can be determined. Here, we reinvestigate a rabbit model in which the intradermal infection of rabbits with ...

Author(s)
Adams, M. M.; Rice, A. D.; Moyer, R. W.
Publisher
American Society for Microbiology (ASM), Washington, USA
Citation
Journal of Virology, 2007, 81, 20, pp 11084-11095
Abstract

This article describes the viral skin diseases affecting the domestic rabbit, the most important being myxomatosis. Transmission and pathogenesis, clinical signs, diagnosis, treatment, and control are described and the article will be of interest to veterinary practitioners who treat rabbits. Shope ...

Author(s)
Meredith, A. L.
Publisher
Elsevier, Inc., New York, USA
Citation
Veterinary Clinics of North America: Exotic Animal Practice, 2013, 16, 3, pp 705-714
Abstract

Author(s)
Ibrahim, M. S.; Meyer, H.
Publisher
Royal Society of Chemistry, Cambridge, UK
Citation
Aerobiology: the toxicology of airborne pathogens and toxins, 2016, pp 42-71
Abstract

Rabbitpox virus (RPXV) is highly virulent for rabbits and it has long been suspected to be a close relative of vaccinia virus. To explore these questions, the complete coding region of the rabbitpox virus genome was sequenced to permit comparison with sequenced strains of vaccinia virus and other...

Author(s)
Li, G.; Chen, N.; Roper, R. L.; Feng, Z.; Hunter, A.; Danila, M.; Lefkowitz, E. J.; Buller, R. M. L.; Upton, C.
Publisher
Society for General Microbiology, Reading, UK
Citation
Journal of General Virology, 2005, 86, 11, pp 2969-2977
Abstract

Smallpox was one of the most devastating diseases known to humanity. Although smallpox was eradicated through a historically successful vaccination campaign, there is concern in the global community that either Variola virus (VARV), the causative agent of smallpox, or another species of ...

Author(s)
Chapman, J. L.; Nichols, D. K.; Martinez, M. J.; Raymond, J. W.
Publisher
American College of Veterinary Pathologists Inc., Lawrence, USA
Citation
Veterinary Pathology, 2010, 47, 5, pp 852-870
Abstract

Rabbit pox virus (RPV) B5R or wild-type (wt) RPV was injected into rabbits (intradermal inoculation) and mice (intranasal inoculation). Rabbits infected with wt RPV underwent a sharp increase in body temperature 2 days after inoculation until death. No significant increase in body temperature...

Author(s)
Stern, R. J.; Thompson, J. P.; Moyer, R. W.
Citation
Virology (New York), 1997, 233, 1, pp 118-129

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