Objective: To describe the pharmacokinetics of ketamine following a short intravenous (IV) infusion to isoflurane-anesthetized rabbits. Study design: Prospective experimental study. Animals: A total of six adult healthy female New Zealand White rabbits. Methods: Anesthesia was induced with...

Rabbits are a common companion animal and research subject and frequently require sedation to facilitate procedures. The objective of this study was to compare the effects of intramuscular butorphanol and midazolam combined with either alfaxalone or ketamine in rabbits. In a complete crossover...

D-α-tocopheryl polyethylene glycol succinate (Vitamin E TPGS or TPGS) has been approved by food and drug administration (FDA) as harmless adjuvant and is largely used in drug systems delivery. Physicochemical and biological possessions of TPGS provide many advantages for its usage in drug delivery, ...

This study aimed to determine the anesthetic efficacy of intranasal medetomidine/ketamine and diazepam/ketamine combinations in New Zealand White rabbits. For this purpose, 12 adult New Zealand White rabbits weighing 2.3-4.1 kg were used by randomly dividing the animals into two groups of six...

This study aimed to investigate the effects of dexmedetomidine-ketamine and midazolam-ketamine combinations on cardiopulmonary and clinical parameters in New Zealand white rabbits. The DXK group (n = 8) received dexmedetomidine (50 μg/kg) and ketamine (20 mg/kg), and the MDK group (n = 8) received...

This study aimed to investigate the effects of premedication with ascorbic acid (vitamin C) on physiologic parameters before medetomidine-ketamine anesthesia in New Zealand white rabbits. A total of 14 rabbits of both sexes, 1-4 months of age and 2-4 kg in body weight, were used in this study. The ...

New Zealand white rabbits (Oryctolagus cuniculus) are an established in vivo model for the study of structural and functional consequences of vocal-fold vibration. Research design requires invasive laryngotracheal procedures, and the presence of laryngospasms or pain responses (or both) hinder...

Measurement of intraocular pressure (IOP) is a standard procedure in ophthalmic research in animals, specifically in glaucoma research, and the control of IOP is essential during certain veterinary ophthalmic surgeries. We evaluated the effect of isoflurane on IOP in the clinically healthy...

The objective of this projectwas to study the induction of smooth anesthesia characterized by good induction (hypnosis), analgesia and good recovery with mild side effects caused by drugs. The effect of using Ketamine with both xylazine and midazolam KXM was investigated in adult rabbitsand...

With this study, it was aimed to assess the effects of experimentally induced dexmedetomidine-ketamine (DK) and xylazine-ketamine (XK) combinations on clinical parameters and hemodynamic and hematological parameters in rabbits. In the study, 16 male New Zealand breed rabbits were divided into two...