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Abstract

The role of topical corticosteroids in management of Acanthamoeba keratitis (AK) remains controversial. Using a rabbit AK model, we investigated whether corticosteroid use is a risk factor of AK. Acanthamoeba (1×105/ml) was incubated with two densities of P. aeruginosa (PA; high-PA: 1×108/ml,...

Author(s)
Nakagawa, H.; Koike, N.; Ehara, T.; Hattori, T.; Narimatsu, A.; Kumakura, S.; Goto, H.
Publisher
Nature Publishing Group, London, UK
Citation
Scientific Reports, 2019, 9, 1, pp 12821
Abstract

Objectives: This study was aimed to develop dual-purpose natamycin (NAT)-loaded niosomes in ketorolac tromethamine (KT) gels topical ocular drug delivery system to improve the clinical efficacy of natamycin through enhancing its penetration through corneal tissue and reducing inflammation...

Author(s)
El-Nabarawi, M. A.; El-Rehem, R. T. A.; Teaima, M.; Abary, M.; El-Mofty, H. M.; Khafagy, M. M.; Lotfy, N. M.; Salah, M.
Publisher
Taylor & Francis, Abingdon, UK
Citation
Drug Development and Industrial Pharmacy, 2019, 45, 6, pp 922-936
Abstract

Bacterial keratitis is an ocular infection that can lead to severe visual disability. Staphylococcus aureus is a major pathogen of the eye. We recently demonstrated the strong antimicrobial activity of LyeTxI-b, a synthetic peptide derived from a Lycosa erithrognatha toxin. Herein, we evaluated a...

Author(s)
Silva, C. N. da; Silva, F. R. da; Dourado, L. F. N.; Reis, P. V. M. dos; Silva, R. O.; Costa, B. L. da; Nunes, P. S.; Amaral, F. A.; Santos, V. L. dos; Lima, M. E. de; Silva Cunha Júnior, A. da
Publisher
MDPI AG, Basel, Switzerland
Citation
Toxins, 2019, 11, 4, pp 203
Abstract

Bacterial keratitis is an aggressive infectious corneal disease. With the continuing rise in antibiotic resistance and a decline in the discovery of new antibiotics, new antimicrobial drugs are now required. In the present study, we determined the antibacterial activity of diacerein, an...

Author(s)
Zhang HongMin; Liu SuSu; Yue Juan; Sun ShengTao; Lv QiXue; Jian ShouJun; Xie YanTing; Han Lei; Zhang FenFen; Dai YanFang; Wang LiYa
Publisher
American Society for Microbiology (ASM), Washington, D.C., USA
Citation
Antimicrobial Agents and Chemotherapy, 2019, 63, 4, pp e01874
Abstract

A 10-year-old male castrated Holland Lop rabbit (Oryctolagus cuniculus) was presented for severe ulcerative stromal keratitis of the right eye and a luxated hypermature cataract and glaucoma of the left eye. Staged bilateral enucleation was elected. A LigaSure™ electrosurgical bipolar...

Author(s)
Moore, B. A.; Robertson, J.; Tarbert, D. K.; Good, K. L.; Paul-Murphy, J. R.
Publisher
Wiley, Boston, USA
Citation
Veterinary Ophthalmology, 2020, 23, 2, pp 409-413
Abstract

Eosinophilic keratitis has been described in horses, cats and rabbits. It can be a frustrating condition for owners, veterinarians and animals. In horses there is often a seasonal element to the condition, but the exact aetiopathogenesis has not yet been determined. Medical treatment is usually...

Author(s)
Hartley, C.
Publisher
BMJ Publishing Group, London, UK
Citation
In Practice, 2018, 40, 5, pp 204-208
Abstract

Purpose: Moxifloxacin (MXN) is widely prescribed for the treatment of bacterial keratitis. The conventional MXN solution has several limitations, including short precorneal residence time and poor intrastromal bioavailability, requiring frequent instillation of the drug to achieve the desired...

Author(s)
Bharti, S. K.; Karthikeyan Kesavan
Publisher
Taylor & Francis, Philadelphia, USA
Citation
Ocular Immunology and Inflammation, 2017, 25, 4, pp 463-474
Abstract

Purpose: In the study of microbial keratitis, in vivo animal models often require a large number of animals, and in vitro monolayer cell culture does not maintain the three-dimensional structure of the tissues or cell-to-cell communication of in vivo models. Here, we propose reproducible ex vivo...

Author(s)
Pinnock, A.; Nagaveni Shivshetty; Sanhita Roy; Rimmer, S.; Douglas, I.; MacNeil, S.; Garg, P.
Publisher
Springer-Verlag GmbH, Berlin, Germany
Citation
Graefe's Archive for Clinical and Experimental Ophthalmology, 2017, 255, 2, pp 333-342
Abstract

This study aims to develop a cross-linked decellularized porcine corneal graft (cDPC) as a substitute for lamellar donor corneas and to evaluate the feasibility of using cDPC to treat fungal keratitis. The cDPC was prepared by decellularization, chemical crosslinking and γ-ray irradiation....

Author(s)
Lin YongLiang; Zheng QinXiang; Hua ShanShan; Meng YongChun; Chen Wei; Wang YiFei
Publisher
Nature Publishing Group, London, UK
Citation
Scientific Reports, 2017, 7, 1, pp 9955
Abstract

Purpose: To investigate voriconazole (VRZ) penetration and fungal load in the cornea after applying VRZ therapy with various treatment combinations in a fungal keratitis model. Methods: Fifty-four eyes of 27 young albino rabbits were provided for this experimental study. Twelve corneas were...

Author(s)
Kalkancİ, A.; Yesİlİrmak, N.; Ozdemİr, H. B.; Unal, E. A.; Erdoğan, M.; Seker, T.; Tum, A. E.; Karakus, A. K.; Hİzel, K.; Bİlgİhan, K.
Publisher
Lippincott Williams & Wilkins, Inc., Hagerstown, USA
Citation
Cornea, 2018, 37, 11, pp 1463-1467

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