Objective: To investigate the effect of itraconazole(ITZ) on hypertrophic scar fibrosis in rabbit ears. Methods: A rabbit ear hypertrophic scar model was established, and 25 New Zealand rabbits were randomly divided into blank group(group A), immediate intervention group after surgery(group B1,...

Atherosclerosis is a chronic inflammatory disease and begins with the dysfunction of the endothelial layer of the vessels and continues to change the nature of the area beneath Intima and accumulation of lipoproteins in this area. Itraconazole, with a wide range of antifungal features, has...

Atherosclerosis is a chronic inflammatory disease of the great vessels. The drug Itraconazole, with a full antifungal range has the following important properties: anti-inflammatory feature, its inhibitory effect on the activity of 5-lipoxygenase and Chemotaxis of T-cell and the production of...

Antimycotics commonly used in the therapy of yeast infections are known for their nephrotoxic and hepatotoxic effects. The aim of this study was to test the effect of selected antimycotics (amphotericin B, fluconazole and itraconazole) on a model rabbit kidney RK13 cell line. The viability of cells ...

The present study describes the occurrence of dermatophytes and their antifungal susceptibility in healthy rabbits kept on a farm or in a household as companion animals. Out of 614 animals examined, 146 samples (23.78%) were positive for dermatophytes by direct microscopic examination, and the...

The present study investigated the in vitro inhibitory activity of terbinafine, itraconazole, caspofungin, fluvastatin and ibuprofen against 15 isolates of Pythium insidiosum in double and triple combinations and determined in vivo correlations using rabbits with experimental pythiosis. The minimal ...

This study was designed to investigate the efficacy of essential oils as an alternative prophylaxis and treatment for avian aspergillosis. The in vitro susceptibility of Aspergillus fumigatus, A. flavus, and A. niger strains to antifungal drugs (Nystatin, Amphotericin B (AMP), Ketoconazole (KTC), ...

Dermatophytosis is a common disease in German guinea pigs (38%) and rabbits (8%). Trichophyton mentagrophytes spp. are the most common fungal species isolated from guinea pigs (>90%) and rabbits (>72%), while Microsporum canis occurs only rarely (<3%). The disease is characterised by alopecia with dermal scaling and crusting. Younger animals are more often affected. Dermatophytes can be identified by microscopy of trichograms and preparations after cultivation, or by using molecular techniques (e.g. PCR). Effective therapy (ESCCAP guidelines) includes the treatment of affected animals with topical (e.g. enilconazole) and parenteral antifungals (e.g. itraconazole) as well as decontamination of their...

Sources of infection for Trichophyton (T.) mentagrophytes - a zoophilic dermatophyte-comprise pet rodents (guinea pigs, mice, rabbits) and sometimes cats. Human infections due to dermatophytes after contact with zoo animals, however, are extreme rare. Four zoo keepers from Basel Zoo were diagnosed...

The purpose of the study was to evaluate the effectiveness of caspofungin and voriconazole in the treatment of experimental Aspergillus otits media in an experimental rabbit model. A total of 30 New Zealand white rabbits were divided into four treatment groups and one control group. The rabbits...