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Flumazenil, a competitive GABAA receptor antagonist, is commonly used in rabbits to shorten sedation or postanesthetic recovery after benzodiazepine administration. However, no combined pharmacokinetic (PK) and pharmacodynamic (PD) data are available to guide its administration in this species. In...
Rabbits are a common companion animal and research subject and frequently require sedation to facilitate procedures. The objective of this study was to compare the effects of intramuscular butorphanol and midazolam combined with either alfaxalone or ketamine in rabbits. In a complete crossover...
The objective of this study was to investigate the short-term cardiovascular effects of intravenous (IV) medetomidine-midazolam-fentanyl (MMF) injections in the rabbit using vascular ultrasonography and echocardiography. Anesthesia with MMF was induced intramuscularly (IM) in 8 female New Zealand...
Unbound fractions of 14C-labelled diazepam and tenoxicam in skim milk of various species (man, mare, goat, cow, ewe, dog, rabbit) with different milk compositions were determined. Furthermore, the protein binding of 5 14C-labelled benzodiazepines differing in their lipophilicity (bromazepam,...