Clostridium perfringens is an opportunistic pathogen. Its main virulence factors are exotoxins, which are the etiological agents of enteritis necroticans and enterotoxemia caused in livestock (cattle, sheep, and rabbits). Here, we demonstrated effective immune protection for rabbits against α, β,...

Clostridium perfringens (C. perfringens) is a foodborne pathogen that represent a high risk to animals and poultry due to its high outbreak incidences worldwide causing diseases such as necrotic enteritis in chickens, enterotoxemia in rabbits and necro-hemorrhagic enteritis in calves leading to...

Clostridium perfringens epsilon toxin (ETX) and Clostridium septicum alpha toxin (CSA) are lethal and necrotizing toxins, which play key roles in enterotoxemia and braxy of ruminants, respectively. In the present study, we synthesized a bivalent chimeric protein rETX_m3CSA_m4/TMD comprising ETX_m3...

Enterotoxaemia, a disease that affects domestic ruminants, is caused by the epsilon toxin of Clostridium perfringens type D and B. Control and prophylaxis are based on systemic vaccination of small ruminant herds with epsilon toxoid. Purified epsilon toxin is an essential material for vaccine...

Wild cottontail rabbits (Sylvilagus spp.), especially young individuals, are one of the most frequent wildlife species presented for rehabilitation at wildlife rehabilitation centers. These species are challenging to rehabilitate, with gastrointestinal (GI) disease being a major cause of morbidity...

An outbreak of high mortality occurred in a closed organized laboratory rabbit colony was investigated. In this outbreak 97/334 (29%) New Zealand White rabbits died suddenly within 3 days in early winter season. Major necropsy findings were soiling of hind quarter, haemorrhagic typhlitis, pulmonary ...

Enterotoxaemia is one of the hazardous diseases of the livestock. In Pakistan prophylaxis failure is due to the vaccination with type D monovalent vaccine. There is a need to develop a cost effective multivalent vaccine against enterotoxaemia using characterized toxinotypes isolated from field....

This study was conducted to evaluate and compare the effects of vitamin E supplementation on humoral immunity against Clostridium perfringens type D epsilon toxin in goats to sort out better immunogenic approach. This study was conducted on total of 36 healthy animal of equal number of rabbits and...

In commercial rabbitries, enteritis are considered a major cause of economic loss. Among the infectious agents responsible for enteritis/enterotoxaemia, Clostridium. perfringens, C. difficile and C. spiroforme are the most common isolates even if the role played by C. perfringens in rabbit...