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Abstract

Treatment options for Exserohilum rostratum meningoencephalitis and other causes of phaeohyphomycosis of the central nervous system (CNS) are limited, while mortality and morbidity remain high. We therefore evaluated isavuconazole, a new antifungal triazole in comparison to liposomal amphotericin B ...

Author(s)
Petraitis, V.; Petraitiene, R.; Katragkou, A.; Maung BoBoWin; Moradi, P. W.; Sussman-Straus, G. E.; Naing, E.; Kovanda, L. L.; Finkelman, M. A.; Walsh, T. J.
Publisher
Oxford University Press, Oxford, UK
Citation
Medical Mycology, 2021, 59, 2, pp 189-196
Abstract

Safety studies are essential in drug development. This study evaluates the safety of Amphotericin A21 (AmB-A21), a derivative of amphotericin B with antifungal therapeutic potential. We performed a chronic toxicity study, a targeted organ study and a dermal irritation test. To evaluate chronic...

Author(s)
Ortega-Blake, I.; Fernández-Zertuche, M.; Regla, I.; Sánchez-Peña, W.; Gómez-Solis, A.; Jaimes-Chavez, P.; Galván-Hernández, A.; Tovar-Garduño, E.; Rodríguez-Fragoso, L.
Publisher
Wiley, Copenhagen, Denmark
Citation
Basic and Clinical Pharmacology and Toxicology, 2021, 129, 1, pp 72-81
Abstract

Objective: The aims of this study were as follows. First, we sought to compare the in vitro susceptibility of liposomal amphotericin B (LAmB) and anidulafungin on Candida albicans and Candida glabrata biofilms growing on silicone discs. Second, we sought to compare the activity of LAmB versus...

Author(s)
Basas, J.; Palau, M.; Gomis, X.; Almirante, B.; Gavaldà, J.
Publisher
Public Library of Sciences (PLoS), San Francisco, USA
Citation
PLoS ONE, 2019, 14, 2, pp e0212426
AbstractFull Text

Background: Fungal endophthalmitis is a sight-threatening disease associated with high morbidity and Aspergillus sp. is the most common causes. Voriconazole (VCZ) and Amphotericin B (AmB) are the most used antifungal drugs, while head-to-head comparison for in vivo intravitreal efficacy is still...

Author(s)
Arianti, A.; Setiabudy, R.; Rozaliyani, A.; Siregar, N. C.; Susiyanti, M.
Publisher
Medical Journal of Indonesia, Jakarta Pusat, Indonesia
Citation
Medical Journal of Indonesia, 2019, 28, 3, pp 215-222
Abstract

Amphotericin B is a first-line agent for the treatment of invasive aspergillosis. However, relatively little is known about the pharmacodynamics of amphotericin B for invasive pulmonary aspergillosis. We studied the pharmacokinetics (PK) and pharmacodynamics (PD) of amphotericin B deoxycholate...

Author(s)
Al-Nakeeb, Z.; Petraitis, V.; Goodwin, J.; Petraitiene, R.; Walsh, T. J.; Hope, W. W.
Publisher
American Society for Microbiology (ASM), Washington, USA
Citation
Antimicrobial Agents and Chemotherapy, 2015, 59, 5, pp 2735-2745
Abstract

Hematogenous Candida meningoencephalitis (HCME) is a life-threatening complication of neonates and immunocompromised children. Amphotericin B (AmB) shows poor permeation and low cerebrospinal fluid (CSF) concentrations but is effective in the treatment of HCME. In order to better understand the...

Author(s)
Petraitis, V.; Petraitiene, R.; Valdez, J. M.; Pyrgos, V.; Lizak, M. J.; Klaunberg, B. A.; Kalasauskas, D.; Basevicius, A.; Bacher, J. D.; Benjamin, D. K., Jr.; Hope, W. W.; Walsh, T. J.
Publisher
American Society for Microbiology (ASM), Washington, D.C., USA
Citation
Antimicrobial Agents and Chemotherapy, 2019, 63, 12, pp e01626
AbstractFull Text

Background: Development of a topical treatment for cutaneous leishmaniasis (CL) is an important step in the improvement of lesion management. Amphotericin B (AmB) is effective against Leishmania species but it is toxic, a Nano-liposomal form of AmB with a size of about 100 nm (Lip-AmB) was...

Author(s)
Eskandari, S. E.; Firooz, A.; Nassiri-Kashani, M.; Jaafari, M. R.; Javadi, A.; Miramin-Mohammadi, A.; Valian-Keshavarz, H.; Khamesipour, A.
Publisher
Tehran University of Medical Sciences, Centre for Electronic Resources Provision and Journal Improvement, Tehran, Iran
Citation
Journal of Arthropod-Borne Diseases, 2018, 12, 3, pp 269-275
Abstract

Cryptococcal meningoencephalitis is a rapidly lethal infection in immunocompromised patients. Induction regimens are usually administered for 2 weeks. The shortest effective period of induction therapy with liposomal amphotericin B (LAMB) is unknown. The pharmacodynamics of LAMB were studied in...

Author(s)
Lestner, J.; McEntee, L.; Johnson, A.; Livermore, J.; Whalley, S.; Schwartz, J.; Perfect, J. R.; Harrison, T.; Hope, W.
Publisher
American Society for Microbiology (ASM), Washington, USA
Citation
Antimicrobial Agents and Chemotherapy, 2017, 61, 6, pp e00090-17
Abstract

Topical application of poorly water-soluble antibiotics cannot achieve the desired therapeutic concentration within cornea. The purpose of this study was to fabricate, characterize and evaluate in-vivo effectiveness of amphotericin B (AmB) containing microneedle ocular patch (MOP) against fungal...

Author(s)
Girdhari Roy; Galigama, R. D.; Thorat, V. S.; Mallela, L. S.; Sanhita Roy; Prashant Garg; Venuganti, V. V. K.
Publisher
Elsevier Ltd, Oxford, UK
Citation
International Journal of Pharmaceutics, 2019, 572,
Abstract

Small-molecule agonists have been identified for TLR7, TLR8, TLR4 and TLR2 thus far, and chemotypes other than those of canonical ligands are yet to be explored for a number of innate immune receptors. The discovery of novel immunostimulatory molecules would enhance the repertoire of tools...

Author(s)
Salyer, A. C. D.; Caruso, G.; Khetani, K. K.; Fox, L. M.; Malladi, S. S.; David, S. A.
Publisher
Public Library of Sciences (PLoS), San Francisco, USA
Citation
PLoS ONE, 2016, 11, 2, pp e0149848

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