Objective: To evaluate alfaxalone for total intravenous anesthesia (TIVA) in rabbits premedicated with dexmedetomidine or dexmedetomidine and buprenorphine. Study design: Crossover study (part 1) with observational study (part 2). Animals: A total of eight New Zealand White rabbits (Oryctolagus...
Author(s)
Bradley, M. P.; Doerning, C. M.; Nowland, M. H.; Pasloske, K.; Lester, P. A.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Veterinary Anaesthesia and Analgesia, 2022, 49, 3, pp 308-312
OBJECTIVE: To determine the dose of alfaxalone for IM administration combined with dexmedetomidine and hydromorphone that would allow endoscopic-guided orotracheal intubation in rabbits without causing a decrease in respiratory rate or apnea. ANIMALS: 15 sexually intact (9 females and 6 males)...
Author(s)
Reabel, S. N.; Queiroz-Williams, P.; Cremer, J.; Hampton, C. E.; Liu ChinChi; Cunha, A. da; Nevarez, J. G.
Publisher
American Veterinary Medical Association, Schaumburg, USA
Citation
Journal of the American Veterinary Medical Association, 2021, 259, 10, pp 1148-1153
This study aimed to investigate the specific pharmacokinetic profile and effects of alfaxalone after intravenous (IV) and intramuscular (IM) administration to rabbits and evaluate the potential interaction with dexmedetomidine. The study design was a blinded, randomized crossover with a washout...
Author(s)
Marín, P.; Belda, E.; Laredo, F. G.; Torres, C. A.; Hernandis, V.; Escudero, E.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Research in Veterinary Science, 2020, 129, pp 6-12
This study compared alfaxalone, alone and in combination with other medications, for sedative and anesthetic properties after intramuscular administration in New Zealand white rabbits. In the main portion of the study, 6 female rabbits were assigned to 5 treatment regimens in a blinded crossover...
Author(s)
Bradley, M. P.; Doerning, C. M.; Nowland, M. H.; Lester, P. A.
Publisher
American Association for Laboratory Animal Science, Memphis, USA
Citation
Journal of the American Association for Laboratory Animal Science, 2019, 58, 2, pp 216-222
Rabbits are a common companion animal and research subject and frequently require sedation to facilitate procedures. The objective of this study was to compare the effects of intramuscular butorphanol and midazolam combined with either alfaxalone or ketamine in rabbits. In a complete crossover...
Author(s)
Knutson, K. A.; Petritz, O. A.; Thomson, A. E.; Balko, J. A.
Publisher
American Association for Laboratory Animal Science, Memphis, USA
Citation
Journal of the American Association for Laboratory Animal Science, 2022, 61, 5, pp 475-481
Objective: To evaluate the effects of alfaxalone administered IM with or without buprenorphine or hydromorphone in healthy rabbits (Oryctolagus cuniculus). Animals: 24 male rabbits undergoing elective orchiectomy between August 21, 2021, and November 6, 2021. Procedures: In this controlled clinical ...
Author(s)
Costa, R. S.; Ciotti-McClallen, M.; Tilley, R.; Perry, S.; Maki, L.; Starks, D.; Stein, A. B.
Publisher
American Veterinary Medical Association, Schaumburg, USA
Citation
Journal of the American Veterinary Medical Association, 2023, 261, 2, pp 223-228
Objective: To compare blind and endoscopic-guided techniques for orotracheal intubation in rabbits and the number of intubation attempts with laryngeal/tracheal damage. Study design: Prospective, randomized experimental study. Animals: A total of 24 healthy, intact female New Zealand White rabbits, ...
Author(s)
Reabel, S. N.; Queiroz-Williams, P.; Cremer, J.; Langohr, I. M.; Cunha, A. F. da; Hampton, C. E.; Carossino, M.; Liu ChinChi; Nevarez, J. G.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Veterinary Anaesthesia and Analgesia, 2022, 49, 4, pp 398-406
To evaluate sedative and physiological effects of low dose intramuscular (IM) alfaxalone, six healthy rabbits were administered single IM doses of alfaxalone at 1 mg/kg (IM1), 2.5 mg/kg (IM2.5), or 5 mg/kg (IM5) with a minimum of 7-day washout period. Sedative effects were subjectively evaluated...
Author(s)
Ishikawa, Y.; Sakata, H.; Tachibana, Y.; Itami, T.; Oyama, N.; Umar, M. A.; Sano, T.; Yamashita, K.
Publisher
Japanese Society of Veterinary Science, Tokyo, Japan
Citation
Journal of Veterinary Medical Science, 2019, 81, 6, pp 851-856
There has not been any report about the use of the Alfaxan-CD(R) in common buzzard. The objective of this study was to evaluate the effects of Alfaxan-CD(R) as an intravenous anesthetic agent for inducing anesthesia in the common buzzard and describe some of its clinical pharmacological effects....
Publisher
Iranian Veterinary Surgery Association, Kermen, Iran
Citation
Iranian Journal of Veterinary Surgery, 2021, 16, 1, pp 24-28
Objective: To investigate the relationship between oxygen administration and ventilation in rabbits administered intramuscular alfaxalone-dexmedetomidine-midazolam. Study design: Prospective, randomized, blinded study. Animals: A total of 25 New Zealand White rabbits, weighing 3.1-5.9 kg and aged 1 ...
Author(s)
Rousseau-Blass, F.; Pang, D. S.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Veterinary Anaesthesia and Analgesia, 2020, 47, 5, pp 637-646