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Abstract

This study aimed to investigate the specific pharmacokinetic profile and effects of alfaxalone after intravenous (IV) and intramuscular (IM) administration to rabbits and evaluate the potential interaction with dexmedetomidine. The study design was a blinded, randomized crossover with a washout...

Author(s)
Marín, P.; Belda, E.; Laredo, F. G.; Torres, C. A.; Hernandis, V.; Escudero, E.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Research in Veterinary Science, 2020, 129, pp 6-12
Abstract

This study compared alfaxalone, alone and in combination with other medications, for sedative and anesthetic properties after intramuscular administration in New Zealand white rabbits. In the main portion of the study, 6 female rabbits were assigned to 5 treatment regimens in a blinded crossover...

Author(s)
Bradley, M. P.; Doerning, C. M.; Nowland, M. H.; Lester, P. A.
Publisher
American Association for Laboratory Animal Science, Memphis, USA
Citation
Journal of the American Association for Laboratory Animal Science, 2019, 58, 2, pp 216-222
Abstract

Alfaxalone is a neuroactive steroid used as a general anaesthetic in several species including dogs, cats, ferrets and rabbits. This study evaluates the anaesthetic, analgesic, sedative and cardiopulmonary effects of Alfaxalone (alfaxan®) constant rate of infusion in Dexmedetomidine (Dexdomitor®)...

Author(s)
Sogebi, E.; Cliff, A. I.
Publisher
Academy of Scientific Research and Technology, National Center for Information and Documentation (NIDOC), Cairo, Egypt
Citation
Egyptian Journal of Veterinary Sciences, 2020, 51, 3, pp 373-379
Abstract

To evaluate sedative and physiological effects of low dose intramuscular (IM) alfaxalone, six healthy rabbits were administered single IM doses of alfaxalone at 1 mg/kg (IM1), 2.5 mg/kg (IM2.5), or 5 mg/kg (IM5) with a minimum of 7-day washout period. Sedative effects were subjectively evaluated...

Author(s)
Ishikawa, Y.; Sakata, H.; Tachibana, Y.; Itami, T.; Oyama, N.; Umar, M. A.; Sano, T.; Yamashita, K.
Publisher
Japanese Society of Veterinary Science, Tokyo, Japan
Citation
Journal of Veterinary Medical Science, 2019, 81, 6, pp 851-856
Abstract

Objective: To investigate the relationship between oxygen administration and ventilation in rabbits administered intramuscular alfaxalone-dexmedetomidine-midazolam. Study design: Prospective, randomized, blinded study. Animals: A total of 25 New Zealand White rabbits, weighing 3.1-5.9 kg and aged 1 ...

Author(s)
Rousseau-Blass, F.; Pang, D. S.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Veterinary Anaesthesia and Analgesia, 2020, 47, 5, pp 637-646
Abstract

Alfaxalone is a neuroactive steroid used as a general anaesthetic in several species including dogs, cats, rabbits and ferrets. It has a wide margin of safety and a similar anaesthetic profile to propofol. To increase its aqueous solubility, a new formulation with cyclodextrins has been marketed...

Author(s)
Arenillas, M.; Gomez de Segura, I. A.
Publisher
Sage Publications Ltd, London, UK
Citation
Laboratory Animals, 2018, 52, 6, pp 588-598
Abstract

Alfaxalone is a neuroactive steroid derivative of pregnanedione that was recently reintroduced to the market for use as an induction agent in small animal anaesthesia. The aim of this study was to determine an intramuscular alfaxalone dose for safe immobilisation. Ten healthy New Zealand white ...

Author(s)
Minh Huynh; Poumeyrol, S.; Pignon, C.; Teuff, G. le; Zilberstein, L.
Publisher
BMJ Publishing Group, London, UK
Citation
Veterinary Record, 2015, 176, 10, pp 255
Abstract

Ten New Zealand White rabbits were used in a crossover experimental study: 200 µg/kg medetomidine and 1 (M1) or 2 mg/kg (M2) morphine were administered intramuscularly. After preoxygenation, anaesthesia was induced with alfaxalone at 10 mg/kg intravenously. The trachea was intubated and 60 per cent ...

Author(s)
Navarrete-Calvo, R.; Gómez-Villamandos, R. J.; Morgaz, J.; Domínguez, J. M.; Fernández-Sarmiento, A.; Muñoz-Rascón, P.; López Vilialba, I.; Mar Granados, M. del
Publisher
BMJ Publishing Group, London, UK
Citation
Veterinary Record, 2014, 174, 4, pp 95
AbstractFull Text

Alfaxalone is a neurosteroid with general anesthetic properties. His steroid structure, analog with progesterone, might have an influence on patient glycaemia. The aim of our study was to assess variations of glycaemia after alfaxalone induction. For this study we used 7 female adult laboratory ...

Author(s)
Cosmin, T. A.; Florin, L.; Alexandru, Ș.; Charlotte, S.
Publisher
Universitatea de Științe Agronomice și Medicină Veterinară București, București, Romania
Citation
Scientific Works - University of Agronomical Sciences and Veterinary Medicine, Bucharest Series C, Veterinary Medicine, 2012, 58, 4, pp 381-386
Abstract

In this study, 30 rabbits were equally divided into 3 groups and were treated with 2.5 ml saline (control), 10 mg/kg propofol and 3.3 mg/kg alfaxalone, respectively. Serum cortisol, heart rate and respiration rate were recorded in all groups. It was shown that cortisol increased 5-60 min after...

Author(s)
Gil, A. G.; Silván, G.; Villa, A.; Illera, J. C.
Publisher
BMJ Publishing Group, London, UK
Citation
Veterinary Record, 2012, 170, 17, pp 444

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