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The tumor-necrotizing polysaccharide employed in the present experiments produced measurable increases in rectal temperature in the rabbit when given intravenously in amounts as low as 0.005 µgm. per kgm. An elevation of from 2 to 8°C. was usually produced when the polysaccharide was given...

Beck, L. V.; Fisher, M.
Cancer Research, 1946, 6, pp 410-420