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Abstract

The objective was to generate evidence for clinical efficacy and acceptability of a second generation coxib, firocoxib, administered orally for 14 days to lame horses under field conditions compared with a classic nonsteroidal anti-inflammatory drug, vedaprofen, in a prospective, randomized,...

Author(s)
Koene, M.; Goupil, X.; Kampmann, C.; Hanson, P. D.; Denton, D.; Pollmeier, M. G.
Publisher
Elsevier, New York, USA
Citation
Journal of Equine Veterinary Science, 2010, 30, 5, pp 237-243
Abstract

The aim of this study was to evaluate the effects vedaprofen on equine skin wound healing. Circular skin lesions using a 2 cm punch were induced on right and left lumbar regions in 14 equines. The animals were divided into two groups and the wounds received daily topic treatment with Dakin...

Author(s)
Hussni, C. A.; Gianini, C. G.; Alves, A. L. G.; Nicoletti, J. L. M.; Thomassian, A.; Crocci, A. J.; Sequeira, J. L.
Publisher
Universidade Federal do Paraná, Curitiba, Brazil
Citation
Archives of Veterinary Science, 2004, 9, 1, pp 87-92
Abstract

The pharmacodynamics and enantioselective pharmacokinetics of vedaprofen were studied in 6 horses in a 2 period cross-over study, in which a mild acute inflammatory reaction was induced by carrageenan soaked sponges implanted s.c. in the neck. Vedaprofen, administered i.v. at a dosage of 1 mg/kg,...

Author(s)
Lees, P.; May, S. A.; Hoeijmakers, M.; Coert, A.; Rens, P. V.
Citation
Journal of Veterinary Pharmacology and Therapeutics, 1999, 22, 2, pp 96-106
Abstract

Recently, successful treatment of mares with a history of persistent mating-induced endometritis (PMIE) with dexamethasone has been reported. As systemic treatment of horses with glucocorticoids should be handled with caution, we tested the hypothesis that treatment with the non-steroid...

Author(s)
Rojer, H.; Aurich, C.
Publisher
Blackwell Publishing, Berlin, Germany
Citation
Reproduction in Domestic Animals, 2010, 45, 6, pp e458-e460
Abstract

Vedaprofen is a chiral nonsteroidal anti-inflammatory drug that has been developed as a gel formulation for oral administration to dogs and horses. The pharmacokinetics of vedaprofen and its enantiomers were studied in beagle dogs after single (intravenous solution and oral gel) and multiple (oral...

Author(s)
Hoeijmakers, M.; Coert, A.; Helden, H. van; Horspool, L. J. I.
Publisher
Blackwell Publishing, Oxford, UK
Citation
Journal of Veterinary Pharmacology and Therapeutics, 2005, 28, 3, pp 305-312
Abstract

Much useful information relevant to elucidation of mechanism of action of nonsteroidal antiinflammatory drugs (NSAIDs) at the molecular level can be obtained from integrating pharmacokinetic (PK) and pharmacodynamic (PD) data, such data being obtained usually, although not necessarily, in separate...

Author(s)
Lees, P.; Giraudel, J.; Landoni, M. F.; Toutain, P. L.
Publisher
Blackwell Publishing, Oxford, UK
Citation
Journal of Veterinary Pharmacology and Therapeutics, 2004, 27, 6, pp 491-502
Abstract

Faeces are a possible medium to be used for horse doping control. Efficient methods for detecting drugs in faeces collected from various animals are routinely applied in institutes of food safety in Belgium. We have already tested whether they are applicable to horse faeces In this report,...

Author(s)
Popot, M. A.; Donval, A.; Bonnaire, Y.; Huau, J.
Publisher
Preston Publications, Niles, USA
Citation
Journal of Analytical Toxicology, 2006, 30, 5, pp 323-330
Abstract

A novel liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed for the trace residue determination of vedaprofen (VPF) in livestock products and seafoods. VPF was extracted from each sample with acidified acetone, and the crude extract was re-extracted with ethyl acetate and ...

Author(s)
Ishihara, M.; Fujita, K.; Ito, H.; Matsuda, T.; Yatsukawa, Y.; Nakamura, M.; Sakai, T.; Nemoto, S.
Publisher
Food Hygienics Society of Japan, Tokyo, Japan
Citation
Shokuhin Eiseigaku Zasshi = Journal of the Food Hygienic Society of Japan, 2011, 52, 5, pp 304-308
Abstract

Author(s)
Ernst, N. S.; Trumble, T. N.
Publisher
John Wiley & Sons, Chichester, UK
Citation
Adams and Stashak's lameness in horses , 2011, Ed.6, pp 975-985
Abstract

As part of a commercial embryo transfer programme, 20 embryos were transferred to spontaneously synchronous or synchronized recipient mares. In 14 cases, embryo recipients were treated with non-steroidal anti-inflammatory drugs (NSAID), receiving flunixin meglumine i.v. at the time of transfer and ...

Author(s)
Koblischke, P.; Budik, S.; Müller, J.; Aurich, C.
Publisher
Blackwell Publishing, Berlin, Germany
Citation
Reproduction in Domestic Animals, 2010, 45, 6, pp 1039-1041

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