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Abstract

Tolazoline is an α2-adrenergic receptor antagonist, used in veterinary medicine to antagonize the central nervous system depressant and cardiovascular effects of α2 receptor agonists. The pharmacokinetics and pharmacodynamic effects of tolazoline when administered subsequent to detomidine in the ...

Author(s)
Casbeer, H. C.; Knych, H. K.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Veterinary Journal, 2013, 196, 3, pp 504-509
Abstract

Objective: To describe the effects of alpha2-adrenergic receptor antagonists on the pharmacodynamics of sublingual (SL) detomidine in the horse. Study design: Randomized crossover design. Animals: Nine healthy adult horses with an average age of 7.6±6.5 years. Methods: Four treatment groups were...

Author(s)
Knych, H. K.; Stanley, S. D.
Publisher
Wiley-Blackwell, Oxford, UK
Citation
Veterinary Anaesthesia and Analgesia, 2014, 41, 1, pp 36-47
Abstract

Alpha2-adrenoceptor agonists xylazine, romifidine, detomidine and, in some cases, medetomidine and dexmedetomidine, are fundamental drugs used in equine practice. There are situations where the undesirable pharmacodynamic effects (ataxia, prolonged sedation, bradycardia and ileus) or accidental...

Author(s)
Zeiler, G. E.
Publisher
Wiley-Blackwell, Oxford, UK
Citation
Equine Veterinary Education, 2015, 27, 1, pp 48-54
Abstract

Objective - To investigate effects of various imidazoline and nonimidazoline α-adrenergic agents on aggregation and antiaggregation of bovine and equine platelets. Sample - Blood samples obtained from 8 healthy adult cattle and 16 healthy adult Thoroughbreds. Procedures - Aggregation and...

Author(s)
Yokota, S.; Hikasa, Y.; Shimura, I.; Kusunose, S.
Publisher
American Veterinary Medical Association, Schaumburg, USA
Citation
American Journal of Veterinary Research, 2013, 74, 3, pp 395-402
Abstract

Reasons for performing study: The ability to shorten the duration of sedation would potentially improve safety and utility of detomidine. Objectives: To determine the effects of tolazoline and atipamezole after detomidine sedation. Hypothesis: Administration of tolazoline or atipamezole would not...

Author(s)
Hubbell, J. A. E.; Muir, W. W.
Publisher
Equine Veterinary Journal Ltd, Newmarket, UK
Citation
Equine Veterinary Journal, 2006, 38, 3, pp 238-241
Abstract

The present study aimed to investigate and evaluate the reversal of sedation, analgesia, ataxia, clinicophysiological findings, and hematobiochemical effects of detomidine by subsequent IV administration of tolazoline or atipamezole to improve safety and utility of detomidine in donkeys. Six mature ...

Author(s)
El-Kammar, M. H.; Gad, S. B.
Publisher
Elsevier, New York, USA
Citation
Journal of Equine Veterinary Science, 2014, 34, 6, pp 784-792
AbstractFull Text

Elective reversal of α-2 adrenergic receptor agonist sedation with either tolazoline or yohimbine is not without serious risk of idiosyncratic and potentially fatal consequences in the horse; as evidenced by clinical reports of drug reaction and possible death resulting from administration of ...

Author(s)
Scofield, D. B.; Alexander, D. L.; Franklin, R. P.; Bertone, J. J.
Publisher
American Association of Equine Practitioners (AAEP), Lexington, USA
Citation
Proceedings of the 56th Annual Convention of the American Association of Equine Practitioners, Baltimore, Maryland, USA, 4-8 December 2010, 2010, pp 44-49
Abstract

Three adult and two subadult greater one-horned rhinoceroses (Rhinoceros unicornis) were sedated a total of nine times using two different intramuscular sedative combinations in order to compare the effectiveness of these combinations in inducing consistent standing sedation in this species. The...

Author(s)
Bapodra, P.; Cracknell, J.; Wolfe, B. A.
Publisher
American Association of Zoo Veterinarians, Pomona, USA
Citation
Journal of Zoo and Wildlife Medicine, 2014, 45, 1, pp 60-68
Abstract

Eighteen mule deer (Odocoileus hemionus) and six Columbia black-tailed deer (Odocoileus hemionus columbianus) were held in pens and repeatedly anesthetized from April 2004 through June 2005 as part of an external parasite study. Deer were anesthetized using a combination of Telazol® and xylazine...

Author(s)
Mortenson, J. A.; Robison, J. A.
Publisher
American Association of Zoo Veterinarians, Lawrence, USA
Citation
Journal of Zoo and Wildlife Medicine, 2011, 42, 1, pp 105-107
AbstractFull Text

Since Xylazine (XYLA) is commonly used in equine practice, and because its use can result in adverse effects even with combination with analgesics, a reliable and safe pharmacological antagonist would be useful. The aim of this study is to compare the efficacy of Tolazoline (TOLA) and Atipamezole...

Author(s)
Abdel-Wahed, R. E.; El-Kammar, M. H.; Abu-Ahmed, H.; El-Khenany, H.
Publisher
Faculty of Veterinary Medicine, Alexandria University, Behira, Egypt
Citation
Alexandria Journal of Veterinary Sciences, 2011, 34, 1, pp 11-20

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