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Abstract

Antibiotics-based therapy plays a paramount role in equine medicine because of their potential pharmacokinetics and pharmacodynamics properties. Conventional antibiotics show bacteriostatic and bactericidal properties by interfering bacterial cell wall and protein synthesis as well as inhibiting...

Author(s)
Ameer Khusro; Chirom Aarti; Buendía-Rodriguez, G.; Arasu, M. V.; Al-Dhabi, N. A.; Barbabosa-Pliego, A.
Publisher
Elsevier, New York, USA
Citation
Journal of Equine Veterinary Science, 2021, 97,
Abstract

The objective of this study was to determine the pharmacokinetics of meropenem in horses after intravenous (IV) administration. A single IV dose of meropenem was administered to six adult horses at 10 mg/kg. Plasma and synovial fluid samples were collected for 6 hr following administration....

Author(s)
Langston, V. C.; Fontenot, R. L.; Byers, J. A.; Andrews, C. M.; Mochal-King, C. A.
Publisher
Wiley, Oxford, UK
Citation
Journal of Veterinary Pharmacology and Therapeutics, 2019, 42, 5, pp 525-529
Abstract

Background: Intraperitoneal administration of ceftriaxone maintains therapeutic abdominal concentrations for 24 hours in healthy horses. Therefore, it is a possible treatment for septic peritonitis. The aim of this study was to evaluate the efficacy of ceftriaxone as an adjuvant treatment in horses ...

Author(s)
Alonso, J. de M.; Rosa, G. dos S.; Santos, B.; Guerra, S.; Ribeiro, M.; Watanabe, M. J.; Alves, A.; Rodrigues, C.; Takahira, R. K.; Hussni, C. A.
Publisher
BMJ Publishing Group, London, UK
Citation
Veterinary Record, 2020, 187, 4, pp e29-e29
Abstract

Cephalosporin antimicrobials can be utilized for the treatment of sepsis in neonatal foals, particularly when an aminoglycoside is contraindicated. Some cephalosporins, however, are not utilized because of cost, sporadic availability, or uncertainty about efficacy. The plasma disposition of...

Author(s)
McNeal, C. D.; Ryan, C. A.; Berghaus, L. J.; Credille, B. C.; Lo ChihPing; Fajt, V. R.
Publisher
Wiley, Oxford, UK
Citation
Journal of Veterinary Pharmacology and Therapeutics, 2021, 44, 4, pp 560-567
Abstract

Intraperitoneal (IP) use of antimicrobial agents may lead to therapeutic effects with better clinical results than intravenous (IV) administration. The aim of this study was to compare plasma and peritoneal fluid concentrations of ceftriaxone after IP and IV administration in horses, and to...

Author(s)
Alonso, J. M.; Peccinini, R. G.; Campos, M. L.; Nitta, T. Y.; Akutagawa, T. Y. M.; Crescencio, A. P.; Alves, A. L. G.; Rodrigues, C. A.; Watanabe, M. J.; Hussni, C. A.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Veterinary Journal, 2018, 234, pp 72-76
Abstract

Peritonitis in horses persists with high incidence and mortality, requiring more innovative and effective therapeutic strategies. The aim of this study was to evaluate Tenckhoff catheters and intraperitoneal use of ceftriaxone in horses. Ten healthy, male horses, with an average age of 5 years,...

Author(s)
Alonso, J. de M.; Nitta, T. Y.; Akutagawa, T. Y. M.; Crescencio, A. P.; Takahira, R. K.; Santos, B. dos; Alves, A. L. G.; Watanabe, M. J.; Rodrigues, C. A.; Peccinini, R. G.; Campos, M. L. de; Hussni, C. A.
Publisher
Elsevier, New York, USA
Citation
Journal of Equine Veterinary Science, 2017, 53, pp 55-63
Abstract

Background: Lyme borreliosis is a disease transmitted by ticks to mammals, especially in horses and humans. Caused by a spirochete Borrelia burgdorferi, it can result in lameness, arthritis, carditis, dermatitis and neurological signs. Anaphylactoid reactions are severe responses caused by direct...

Author(s)
Basile, R. C.; Rivera, G. G.; Rio, L. A. del; Bonis, T. C. M. de; Amaral, G. P. D. do; Giangrecco, E.; Ferraz, G.; Yoshinari, N. H.; Canola, P. A.; Queiroz Neto, A.
Publisher
BioMed Central Ltd, London, UK
Citation
BMC Veterinary Research, 2015, 11, 197, pp (12 August 2015)
Abstract

OBJECTIVE: To compare antibacterial effects among 3 types of foam used with negative-pressure wound therapy (NPWT) in an ex vivo equine perfused wound model. SAMPLES: Abdominal musculocutaneous flaps from 6 equine cadavers. PROCEDURES: Each musculocutaneous flap was continuously perfused with...

Author(s)
Hecke, L. L. van; Haspeslagh, M.; Hermans, K.; Martens, A. M.
Publisher
American Veterinary Medical Association, Schaumburg, USA
Citation
American Journal of Veterinary Research, 2016, 77, 12, pp 1325-1331
Abstract

Ceftriaxone is a cephalosporin antibiotic with a potent antimicrobial activity and excellent penetration in most body fluids such as pleural, peritoneal, spinal and brain. These facts contribute to the application of ceftriaxone in the treatment of bacterial peritonitis, an abdominal disorder in...

Author(s)
Campos, M. L.; Alonso, J. de M.; Martins, E. dos S.; Oliveira, J. A.; Hussni, C. A.; Peccinini, R. G.
Publisher
Elsevier, New York, USA
Citation
Diagnostic Microbiology and Infectious Disease, 2017, 88, 1, pp 95-99
Abstract

A subpalpebral lavage catheter is commonly used to administer medications in the treatment of infectious keratitis in horses. Drugs may mix in the subpalpebral lavage catheter, potentially affecting antimicrobial efficacy. The objective of this study was to determine the in vitro antimicrobial...

Author(s)
Johns, I. C.; Beech, J.; Benson, C. E.; Parente, L. L.
Publisher
Elsevier, New York, USA
Citation
Journal of Equine Veterinary Science, 2010, 30, 5, pp 231-236

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