Background: Synovial sepsis of unknown origin is a rare cause of lameness in the adult horse, and a haematogenous pathogenesis has been proposed in previous cases. Objectives: To describe the features and outcome of synovial sepsis of unknown origin in adult Thoroughbred racehorses. Study design:...

Objective: To determine meropenem concentrations in radiocarpal (RC) joint fluid and plasma after intravenous regional limb perfusion (IVRLP). Study design: In vivo experimental study. Animals: Nine healthy adult mares. Methods: Meropenem (500 mg) was injected in the forelimb of standing sedated ...

Clinical samples from 123 foals with suspected rhodococcosis submitted to the Veterinary Microbiological Diagnostic Centre of the Faculty of Veterinary Medicine between 1993 and 2006 were tested for the presence of the virulence gene vapA. Of the 123 samples, 120 were vapA-positive and 3 ...

Platelet-rich plasma (PRP) products may be useful for treatment of joint disease in horses, but may contain undesirable pro-inflammatory cytokines in addition to growth factors. This study investigated whether autologous PRP increases synovial fluid growth factor and cytokine concentrations when...

Bacterial colonization of synovial structures can cause infections that are difficult to treat. Systemic and local antimicrobials and repeated joint lavages are the mainstays of therapy. However, despite aggressive treatments, infection may persist, leading to significant tissue damage or death of...

The potential of five different commercial DNA isolation methods to remove real-time PCR inhibitors from the synovial fluid of horses, cattle and pigs was investigated. All kits with the exception of one included a silica column-based purification of the DNA. With the fifth kit, DNA purification is ...

Septic arthritis is a debilitating joint infectious disease of equines that requires early diagnosis and immediate therapeutic intervention to prevent degenerative effects on the articular cartilage, as well as loss of athletic ability and work performance of the animals. Few studies have...

Discriminating septic and non-septic arthritis when investigating an equine synovial fluid is the most frequent and relevant objective. Definitive diagnosis (bacteria isolation) is often established lately when effectively achieved. In adjunction to the microbiological investigation, the...

This article describes the acute onset of infectious polyarthritis and osteomyelitis in a 4-week-old foal. Analysis of synovial fluid obtained from the left femoropatellar and right tarsocrural joints combined with clinical signs consisting of joint effusion and lameness yielded a diagnosis of...

Synovial fluid (SF) was collected at 2, 12 and 26 h after racing from 5 Thoroughbred horses with degenerative joint disease. A significant induction in tumour necrosis factor-α (TNFα) bioactivity was detected in SF from arthritic joints compared to the control joints over the 26 h following racing. ...