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Abstract

Background: Septicaemia in the neonatal foal is caused by both Gram positive and Gram negative bacteria. The life-threatening nature of this condition requires treatment to be initiated with broad spectrum antimicrobial drugs pending antimicrobial susceptibility testing. Potentiated sulphonamides,...

Author(s)
Ekstrand, C.; Nostell, K.; Gehring, R.; Bondesson, U.; Bröjer, J.
Publisher
Wiley, Oxford, UK
Citation
Veterinary Medicine and Science, 2022, 8, 3, pp 1065-1071
Abstract

There is limited investigation of neonatal foal pharmacokinetic parameters for the antimicrobial combination of sulfadiazine (SDZ) and trimethoprim (TMP). Neonatal pharmacokinetic investigation of the sulfadiazine-trimethoprim combination is required to ensure safe and effective utilization in this ...

Author(s)
O'Fallon, E. S.; McCue, P.; Rao, S.; Gustafson, D. L.
Publisher
Wiley, Oxford, UK
Citation
Journal of Veterinary Pharmacology and Therapeutics, 2020, 44, 4, pp 552-559
Abstract

OBJECTIVE: To determine whether administration of trimethoprim-sulfadiazine (TMS), detomidine (DET), or TMS plus DET would be associated with changes in ECG repolarization parameters in horses. ANIMALS: 9 healthy adult horses. PROCEDURES: Each horse received 4 treatments in a blinded, randomized,...

Author(s)
Trachsel, D. S.; Calloe, K.; Jørgensen, E.; Lunddahl, C. S.; Pedersen, P. J.; Kanters, J. K.; Klaerke, D. A.; Buhl, R.
Publisher
American Veterinary Medical Association, Schaumburg, USA
Citation
American Journal of Veterinary Research, 2021, 82, 3, pp 207-217
Abstract

Antimicrobial susceptibility test results for trimethoprim-sulfadiazine with Streptococcus equi subspecies are interpreted based on human data for trimethoprim-sulfamethoxazole. The veterinary-specific data generated in this study support a single breakpoint for testing ...

Author(s)
Sadaka, C.; Kanellos, T.; Guardabassi, L.; Boucher, J.; Watts, J. L.
Publisher
American Society for Microbiology (ASM), Washington, USA
Citation
Journal of Clinical Microbiology, 2017, 55, 1, pp 326-330
Abstract

The objective of this experiment was to assess the concentrations of sulfadiazine and trimethoprim in the blood and endometrium of nonpregnant mares after oral treatment. We hypothesized that the potentiated sulfonamide would reach tissue concentrations greater than the minimum inhibitory...

Author(s)
Davolli, G. M.; Beavers, K. N.; Medina, V.; Sones, J. L.; Pinto, C. R. F.; Paccamonti, D. L.; Causey, R. C.
Publisher
Elsevier, New York, USA
Citation
Journal of Equine Veterinary Science, 2018, 67, pp 27-30
Abstract

We hypothesized that a novel oral suspension of potentiated sulfonamide would reach adequate tissue concentrations greater than the in vitro MIC reported for common uterine pathogens. The objective of our experiment was to assess the concentrations of sulfadiazine-trimethoprim in plasma and the...

Author(s)
Davolli, G. M.; Beavers, K.; Medina, V.; Sones, J.; Pinto, C. R. F.; Paccamonti, D.; Causey, R.
Publisher
The Society for Theriogenology, Montgomery, USA
Citation
Clinical Theriogenology, 2017, 9, 3, pp 419
Abstract

The long QT syndrome (LQTS) is a channelopathy that can lead to severe arrhythmia and sudden cardiac death. Pharmacologically induced LQTS is caused by interaction between drugs and potassium channels, especially the Kv11.1 channel. Due to such interactions, numerous drugs have been withdrawn from...

Author(s)
Trachsel, D. S.; Tejada, M. A.; Christensen, V. G.; Pedersen, P. J.; Kanters, J. K.; Buhl, R.; Calloe, K.; Klaerke, D. A.
Publisher
Wiley, Oxford, UK
Citation
Journal of Veterinary Pharmacology and Therapeutics, 2018, 41, 4, pp 536-545
Abstract

The aim of this study was to investigate the safety and pharmacokinetics of trimethoprim-sulphadiazine administered via intravenous regional limb perfusion (IVRLP) into the cephalic vein. According to the hypothesis, the drug could be administered without adverse effects and the synovial...

Author(s)
Gustafsson, K.; Tatz, A. J.; Dahan, R.; Ahmad, W. A.; Britzi, M.; Sutton, G. A.; Kelmer, G.
Publisher
MDPI AG, Basel, Switzerland
Citation
Animals, 2021, 11, 7,
Abstract

Objective - To evaluate the effectiveness of a novel trimethoprim-sulfadiazine oral suspension for the treatment of naturally acquired Streptococcus equi subsp. zooepidemicus infection in horses. Design - Randomized, controlled field trial. Animals-180 horses with S. equi subsp. zooepidemicus...

Author(s)
McClure, S. R.; Koenig, R.; Hawkins, P. A.
Publisher
American Veterinary Medical Association, Schaumburg, USA
Citation
Journal of the American Veterinary Medical Association, 2015, 246, 12, pp 1345-1352
AbstractFull Text

In vitro susceptibility testing of 479 bacterial isolates from horses, including Streptococcus equi subsp.zooepidemicus (n = 282), S. equi subsp. equi (n = 55), Corynebacterium pseudotuberculosis (n = 96), and Actinobacillus equuli (n = 46) revealed that 478 (99.7%) were highly susceptible to both ...

Author(s)
Wilson, W. D.; Edman, J. E.
Publisher
American Association of Equine Practitioners (AAEP), Lexington, USA
Citation
Proceedings of the 66th Annual Convention of the American Association of Equine Practitioners, December 2020 (online), 2020, pp 432-435

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