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Abstract

Proton pump inhibitors such as omeprazole reduce nutrient digestibility in humans. This study determined the effect of omeprazole on the digestibility of diets containing limestone or marine-derived calcium (BMC) and to assess changes in blood parameters associated with gastric acid production and...

Author(s)
Pagan, J. D.; Petroski-Rose, L.; Mann, A.; Hauss, A.
Publisher
Elsevier, New York, USA
Citation
Journal of Equine Veterinary Science, 2020, 86, pp 102851
Abstract

Background: Guidelines regarding the impact and value of prophylaxis or maintenance therapy in equine gastric ulcer syndrome (EGUS) are not well-established or defined. The merits and the magnitude of effects of prophylaxis for spontaneous or recurrent squamous gastric ulceration in horses in...

Author(s)
Mason, L. V.; Moroney, J. R.; Mason, R. J.
Publisher
Wiley, Oxford, UK
Citation
Equine Veterinary Journal, 2019, 51, 1, pp 11-19
Abstract

Background: Previous studies have demonstrated a poor response to healing of gastric glandular lesions with oral omeprazole and other medications. Objectives: To evaluate the efficacy of two novel treatments (misoprostol [M] and combined omeprazole-sucralfate [OS]) in horses for gastric glandular...

Author(s)
Varley, G.; Bowen, I. M.; Habershon-Butcher, J. L.; Nicholls, V.; Hallowell, G. D.
Publisher
Wiley, Oxford, UK
Citation
Equine Veterinary Journal, 2019, 51, 5, pp 575-580
Abstract

Background: Anecdotally, aloe vera is used to treat gastric ulceration, although no studies have yet investigated its efficacy in horses. Objectives: To test the hypothesis that aloe vera would be noninferior to omeprazole in the treatment of equine gastric ulcer syndrome. Study Design: Randomised, ...

Author(s)
Bush, J.; Boom, R. van den; Franklin, S.
Publisher
Wiley, Oxford, UK
Citation
Equine Veterinary Journal, 2018, 50, 1, pp 34-40
Abstract

AIMS: To compare the efficacy of an enteric coated esomeprazole paste with an enteric coated omeprazole paste to increase gastric pH after oral administration in horses. METHODS: Nine adult Standardbred horses were randomly assigned to three groups, each containing three horses, for a study...

Author(s)
Huxford, K. E.; Dart, A. J.; Perkins, N. R.; Bell, R.; Jeffcott, L. B.
Publisher
Taylor & Francis, Melbourne, Australia
Citation
New Zealand Veterinary Journal, 2017, 65, 6, pp 318-321
Abstract

Medication control and doping control have been established in horse racing to ensure the integrity of the sport and the welfare of the horses. This ensures that horses do not compete under the influence of any drugs, including omeprazole, a therapeutic medication used to treat equine gastric ulcer ...

Author(s)
Viljanto, M.; Hillyer, L.; Hincks, P.; Pearce, C.; Paine, S. W.
Publisher
Wiley, Oxford, UK
Citation
Journal of Veterinary Pharmacology and Therapeutics, 2018, 41, 3, pp 469-475
Abstract

OBJECTIVE: To determine the effects of oral omeprazole administration on the fecal and gastric microbiota of healthy adult horses. ANIMALS: 12 healthy adult research horses. PROCEDURES: Horses were randomly assigned to receive omeprazole paste (4 mg/kg, PO, q 24 h) or a sham (control) treatment...

Author(s)
Tyma, J. F.; Epstein, K. L.; Whitfield-Cargile, C. M.; Cohen, N. D.; Giguère, S.
Publisher
American Veterinary Medical Association, Schaumburg, USA
Citation
American Journal of Veterinary Research, 2019, 80, 1, pp 79-86
Abstract

This study aimed to investigate the effect of diet and dose on the pharmacokinetics of omeprazole in the horse. Six horses received two doses (1 and 4 mg/kg) of omeprazole orally once daily for 5 days. Each dose was evaluated during feeding either a high-grain/low-fibre (HG/LF) diet or an ad...

Author(s)
Sykes, B. W.; Underwood, C.; McGowan, C. M.; Mills, P. C.
Publisher
Wiley, Oxford, UK
Citation
Journal of Veterinary Pharmacology and Therapeutics, 2017, 40, 2, pp 172-178
Abstract

Background: Conflicting data are presented in the current literature regarding the efficacy of omeprazole for suppressing gastric acidity in the horse. Objectives: The objective of this study was to investigate the duration of intraday acid suppression achieved with two doses of omeprazole under...

Author(s)
Sykes, B. W.; Underwood, C.; Greer, R.; McGowan, C. M.; Mills, P. C.
Publisher
Wiley, Oxford, UK
Citation
Equine Veterinary Journal, 2017, 49, 4, pp 525-531
Abstract

Background: Pilot investigations have suggested that a novel, long-acting, injectable i.m. formulation of omeprazole (LA-OMEP) can induce acid suppression for up to 7 days following a single injection. Objectives: To investigate the pharmacodynamics and assess the clinical efficacy of the LA-OMEP...

Author(s)
Sykes, B. W.; Kathawala, K.; Song, Y.; Garg, S.; Page, S. W.; Underwood, C.; Mills, P. C.
Publisher
Wiley, Oxford, UK
Citation
Equine Veterinary Journal, 2017, 49, 6, pp 795-801

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