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Abstract

Background: Misoprostol is an E prostanoid (EP) 2, 3 and 4 receptor agonist that is anecdotally used to treat and prevent NSAID-induced GI injury in horses. Misoprostol elicits anti-inflammatory effects in vivo in men and rodents, and inhibits TNFα production in equine leucocytes in vitro....

Author(s)
Martin, E. M.; Schirmer, J. M.; Jones, S. L.; Davis, J. L.
Publisher
Wiley, Oxford, UK
Citation
Equine Veterinary Journal, 2019, 51, 3, pp 415-421
Abstract

OBJECTIVE: To characterize the pharmacokinetics of a clinically relevant dose of misoprostol administered PO or per rectum (PR) to horses. ANIMALS: 8 healthy adult horses. PROCEDURES: In a randomized 3-way crossover design, horses received a single dose of misoprostol (5 µg/kg) administered PO...

Author(s)
Lopp, C. T.; McCoy, A. M.; Boothe, D.; David J. Schaeffer, K. L.
Publisher
American Veterinary Medical Association, Schaumburg, USA
Citation
American Journal of Veterinary Research, 2019, 80, 11, pp 1026-1033
Abstract

In horses, prostaglandin E2 (PGE2) is produced by embryos around Day 5 post-ovulation; PGE2 functions directly at the oviduct promoting embryo transport into the uterus. Non-surgical collection of horse embryos for cryopreservation is recommended at Day 6.5-7 post-ovulation. It was proposed that ...

Author(s)
Checura, C. M.; Momont, H. W.; Castañeira, C.; Flores-Bragulat, A.; Losinno, L.
Publisher
Elsevier B.V., Amsterdam, Netherlands
Citation
Animal Reproduction Science, 2020, 223,
Abstract

Pro-inflammatory cytokines including tumor necrosis factor α (TNFα), IL-1β, IL-6, and IL-8 are potent immune mediators that exacerbate multiple equine diseases such as sepsis and laminitis. Unfortunately, safe and effective cytokine-targeting therapies are lacking in horses; therefore, novel...

Author(s)
Martin, E. M.; Messenger, K. M.; Sheats, M. K.; Jones, S. L.
Publisher
Frontiers Media S.A., Lausanne, Switzerland
Citation
Frontiers in Veterinary Science, 2017, 4, September, pp 160
Abstract

Background: Previous studies have demonstrated a poor response to healing of gastric glandular lesions with oral omeprazole and other medications. Objectives: To evaluate the efficacy of two novel treatments (misoprostol [M] and combined omeprazole-sucralfate [OS]) in horses for gastric glandular...

Author(s)
Varley, G.; Bowen, I. M.; Habershon-Butcher, J. L.; Nicholls, V.; Hallowell, G. D.
Publisher
Wiley, Oxford, UK
Citation
Equine Veterinary Journal, 2019, 51, 5, pp 575-580
Abstract

In many equine inflammatory disease states, neutrophil activities, such as adhesion, migration, and reactive oxygen species (ROS) production become dysregulated. Dysregulated neutrophil activation causes tissue damage in horses with asthma, colitis, laminitis, and gastric glandular disease....

Author(s)
Martin, E. M.; Till, R. L.; Sheats, M. K.; Jones, S. L.
Publisher
Frontiers Media S.A., Lausanne, Switzerland
Citation
Frontiers in Veterinary Science, 2017, 4, September, pp 159
Abstract

Non-surgical collection of small equine embryos for cryopreservation is recommended at day 6.5 to 7 after ovulation. Collection at day 7 or later will yield large embryos which are not suitable for standard cryopreservation techniques; however, embryo recovery rates are lower for day 6.5 to 7 than...

Author(s)
Checura, C. M.; Momont, H. W.
Publisher
The Society for Theriogenology, Montgomery, USA
Citation
Clinical Theriogenology, 2017, 9, 3, pp 484
Abstract

Misoprostol is a synthetic Prostaglandin E1 (PGE1), one of the prostaglandin E (PGE) family hormones, which promotes oviduct dilatation and motility, reestablishing fertility rates in mares suspected of uterine tubal block. It is known that topical application of PGE on the surface of the uterine...

Author(s)
Alvarenga, M. A.; Segabinazzi, L. G.
Publisher
Elsevier, New York, USA
Citation
Journal of Equine Veterinary Science, 2018, 71, pp 46-50
AbstractFull Text

This paper describes the results of a novel and practical approach to restoring fertility of mares with suspected oviduct pathology and subfertility. It involves the deep-horn application of misoprostol in aqueous suspension applied to the uterine horn tip and oviductal papillae. This technique is...

Author(s)
Alvarenga, M. A.; Segabinazzi, L. G. T. M.
Publisher
American Association of Equine Practitioners (AAEP), Lexington, USA
Citation
Proceedings of the 65th Annual Convention of the American Association of Equine Practitioners, Denver, Colorado, USA, 7-11 December 2019, 2019, pp 41-46
Abstract

Reasons for performing study: To investigate effects of a 5-day oral misoprostol regimen recommended for use in horses as a gastrointestinal mucosal cytoprotectant during colic on mid-gestation pregnancies. Objectives: To monitor cervical tone, ultrasonographic characteristics of the uterus, cervix ...

Author(s)
Jacobson, C. C.; Sertich, P. L.; McDonnell, S. M.
Publisher
Wiley-Blackwell, Oxford, UK
Citation
Equine Veterinary Journal, 2013, 45, 1, pp 91-93

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