Background: Insect-bite hypersensitivity (IBH) in horses is a chronic allergic dermatitis caused by insect bites. Horses suffer from pruritic skin lesions, caused by type-I/type-IV allergic reactions accompanied by prominent eosinophil infiltration into the skin. Interleukin-5 (IL-5) is the key...
Author(s)
Fettelschoss-Gabriel, A.; Fettelschoss, V.; Olomski, F.; Birkmann, K.; Thoms, F.; Bühler, M.; Kummer, M.; Zeltins, A.; Kündig, T. M.; Bachmann, M. F.
Publisher
Wiley, Copenhagen, Denmark
Citation
Allergy, 2019, 74, 3, pp 572-582
Insect bite hypersensitivity (IBH) is a Th-2, IgE-mediated dermatitis of horses caused by bites of insects of the genus Culicoides that has common features with human atopic dermatitis. Together with Th-2 cells, the epithelial barrier plays an important role in development of type I ...
Author(s)
Cvitas, I.; Oberhänsli, S.; Leeb, T.; Dettwiler, M.; Müller, E.; Bruggman, R.; Marti, E. I.
Publisher
Public Library of Sciences (PLoS), San Francisco, USA
Citation
PLoS ONE, 2020, 15, 4,
Background: Recent evidence suggests that an altered intestinal microbiota, specifically a reduction of bacterial diversity or a shift in microbial composition, is associated with the development of hypersensitivity disorders in humans, but this is unknown for horses. Objectives: In this study we...
Author(s)
Kaiser-Thom, S.; Hilty, M.; Gerber, V.
Publisher
Taylor & Francis, Abingdon, UK
Citation
Veterinary Quarterly, 2020, 40, 97-107, pp 97-107
Equine insect bite hypersensitivity (IBH) is a pruritic skin allergy caused primarily by biting midges, Culicoides spp. IBH susceptibility has polygenic inheritance and occurs at high frequencies in several horse breeds worldwide, causing increased costs and reduced welfare of affected horses. The...
Author(s)
Shrestha, M.; Solé, M.; Ducro, B. J.; Sundquist, M.; Thomas, R.; Schurink, A.; Eriksson, S.; Lindgren, G.
Publisher
Wiley, Berlin, Germany
Citation
Journal of Animal Breeding and Genetics, 2020, 137, 2, pp 223-233
Background: Insect bite hypersensitivity IBH is the most common seasonal pruritic allergic dermatitis of horses occurring upon insect bites. In recent years, a major role for IL-31 in allergic pruritus of humans, monkeys, dogs, and mice was acknowledged. Here, we investigate the role of IL-31 in...
Author(s)
Olomski, F.; Fettelschoss, V.; Jonsdottir, S.; Birkmann, K.; Thoms, F.; Marti, E.; Bachmann, M. F.; Kündig, T. M.; Fettelschoss-Gabriel, A.
Publisher
Wiley, Copenhagen, Denmark
Citation
Allergy, 2020, 75, 4, pp 862-871
Background: Genetic, epidemiologic, and clinical evidence suggests that, in horses, there are manifestations of hypersensitivity that can occur together. Objectives: To investigate whether concurrent insect bite hypersensitivity (IBH) and severe equine asthma (EA) is associated with higher...
Author(s)
Verdon, M.; Lanz, S.; Rhyner, C.; Gerber, V.; Marti, E.
Publisher
Wiley, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2019, 33, 1, pp 266-274
Background: Insect bite hypersensitivity (IBH) is an IgE-mediated dermatitis caused by bites of Culicoides spp., which occurs frequently in horses imported from Iceland to continental Europe. IBH does not occur in Iceland because Culicoides species that bite horses are not present. However, ...
Author(s)
Torsteinsdottir, S.; Scheidegger, S.; Baselgia, S.; Jonsdottir, S.; Svansson, V.; Björnsdottir, S.; Marti, E.
Publisher
BioMed Central Ltd, London, UK
Citation
Acta Veterinaria Scandinavica, 2018, 60, 69, pp (3 November 2018)
Genetic variation contributing to the phenotypic variation was utilized in this thesis to understand the genetic background of a complex trait IBH, and to understand genetic diversity and relationships between various horse populations. IBH is the most common skin allergic disorder in horses,...
Author(s)
Merina Shrestha
Publisher
Wageningen University, Wageningen, Netherlands
Citation
Genetics of equine insect bite hypersensitivity and genetic diversity in horses, 2017, pp 86 pp.
In the presented study, the in-vitro allergy test "functional in-vitro test" (FIT) and the "cellular antigen stimulation test or "basophile degranulation test"" (CAST/BDT) were performed in horses suffering from summer eczema and test results were compared to clinical manifestation using a clinical ...
Author(s)
Gehlen, H.; Brunner, M.
Publisher
Hippiatrika Verlag GmbH, Baden-Baden, Germany
Citation
Pferdeheilkunde, 2016, 32, 4, pp 296...305
Background: Insect-bite hypersensitivity is the most common allergic dermatitis in horses. Excoriated skin lesions are typical symptoms of this seasonal and refractory chronic disease. On a cellular level, the skin lesions are characterized by massive eosinophil infiltration caused by an underlying ...
Author(s)
Fettelschoss-Gabriel, A.; Fettelschoss, V.; Thoms, F.; Giese, C.; Daniel, M.; Olomski, F.; Kamarachev, J.; Birkmann, K.; Bühler, M.; Kummer, M.; Zeltins, A.; Marti, E.; Kündig, T. M.; Bachmann, M. F.
Publisher
Elsevier, New York, USA
Citation
Journal of Allergy and Clinical Immunology, 2018, 142, 4, pp 1194-1205.e3