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Abstract

Background: The primary objective of this study was to assess the disposition of furosemide in Thoroughbred horses treated intravenously with 1 mg/kg of furosemide 4 and 24 h before supramaximal treadmill exercise without and with controlled access to water, respectively. Another objective was to...

Author(s)
Villarino, N. F.; Lopez, C. M.; Sams, R. A.; Bayly, W. M.
Publisher
BioMed Central Ltd, London, UK
Citation
BMC Veterinary Research, 2019, 15, 275, pp (2 August 2019)
Abstract

This prospective, cross-sectional, pilot study aimed to investigate the effects of furosemide as a diuretic on the image quality of bone scintigraphy performed using 99mTc-HDP and to investigate the impact of furosemide on the radiation dose rate. Thirty-one horses undergoing bone scintigraphy were ...

Author(s)
Mageed, M.; Wegert, J.; Dyab, S.; Gerlach, K.
Publisher
Wiley, Boston, USA
Citation
Veterinary Radiology & Ultrasound, 2021, 62, 1, pp 126-132
Abstract

Exercise induced pulmonary haemorrhage (EIPH) affecting racehorses continues to raise questions regarding animal welfare and to-date no effective treatment has been identified. The mode of action of furosemide on EIPH, the only medication for the condition accepted in some racing jurisdictions, has ...

Author(s)
Costa, M. F. de M.; Ronchi, F. A.; Yoonsuh, J.; Ivanow, A.; Braga, J. V.; Ramos, M. T.; Casarini, D. E.; Slocombe, R. F.
Publisher
Wageningen Academic Publishers, Wageningen, Netherlands
Citation
Comparative Exercise Physiology, 2018, 14, 2, pp 119-125
Abstract

Background: Due to the high prevalence of EIPH in racehorses and its potential impact on the horse's health, furosemide administration is permitted up to 4-h prior to post time in most North American racing jurisdictions. Anecdotal reports suggest that administration of furosemide 24-h prior to...

Author(s)
Knych, H. K.; Wilson, W. D.; Vale, A.; Kass, P. H.; Arthur, R. M.; Jones, J. H.
Publisher
Wiley, Oxford, UK
Citation
Equine Veterinary Journal, 2018, 50, 3, pp 350-355
Abstract

Furosemide is used to reduce the incidence of exercise-induced pulmonary hemorrhage in racehorses. Previous research suggests furosemide negatively impacts calcium balance, which may have long-term implications for bone health. Eleven healthy horses, either control (CON, n=5) or treatment (FUR,...

Author(s)
Pritchard, A.; Spooner, H.; Hoffman, R.
Publisher
Elsevier, New York, USA
Citation
Journal of Equine Veterinary Science, 2019, 82, pp 102800
Abstract

Previous research documented that furosemide negatively impacted calcium balance for 3 days but did not determine when calcium balance returned to baseline. This study hypothesized that furosemide's impact on calcium would return to control values before 7 days post-administration. Ten mature...

Author(s)
Pritchard, A.; Nielsen, B. D.; Robison, C.; Spooner, H.
Publisher
Wiley, Berlin, Germany
Citation
Journal of Animal Physiology and Animal Nutrition, 2020, 104, 3, pp 946-953
Abstract

Furosemide is a diuretic agent used commonly in racehorses to attenuate the bleeding associated with exercise-induced pulmonary hemorrhage (EIPH). The current study describes serum and urine concentrations and the pharmacokinetics of furosemide following administration at 4 and 24 hrs prior to...

Author(s)
Knych, H. K.; Vale, A.; Wilson, W. D.; Kass, P. H.; Arthur, R. M.; Jones, J. H.
Publisher
Wiley, Oxford, UK
Citation
Journal of Veterinary Pharmacology and Therapeutics, 2018, 41, 2, pp 224-229
Abstract

Background: Public pressure exists in the United States to eliminate race-day furosemide administration despite its efficacy in decreasing the severity of equine exercise pulmonary hemorrhage (EIPH). No effective alternative prophylaxis strategies have been identified. Objective: To investigate...

Author(s)
Bayly, W.; Lopez, C.; Sides, R.; Bergsma, G.; Bergsma, J.; Gold, J.; Sellon, D.
Publisher
Wiley, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2019, 33, 5, pp 2319-2326
Abstract

Although controversial, due to its reported effectiveness in attenuating bleeding associated with exercise-induced pulmonary hemorrhage (EIPH), furosemide is currently a permitted race day medication in most North American racing jurisdictions. The objective of this study was to assess the efficacy ...

Author(s)
Knych, H. K.; Wilson, W. D.; Vale, A.; Kass, P. H.; Steffey, E. P.; Jones, J. H.; Arthur, R. M.
Publisher
Wiley, Oxford, UK
Citation
Journal of Veterinary Pharmacology and Therapeutics, 2020, 43, 6, pp 565-576
AbstractFull Text

The high prevalence of exercise-induced pulmonary hemorrhage (EIPH) in athletic horses constitutes to be a challenge to the racing industry and a source of major concern to animal welfare. Both experimental and clinical evidence indicate that the use of autologous platelet-rich plasma (PRP) is a...

Author(s)
Pires, N. R.; Miranda, S.; Costa, M. F. M.; Ramos, M. T.; Bernardes, C.; Alencar, N. X.; Lessa, D. A. B.
Publisher
FEPMVZ - Editora, Belo Horizonte, Brazil
Citation
Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2021, 73, 3, pp 605-612

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