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Abstract

While toxoplasmosis is not commonly considered a clinical disease of equines, previous seroprevalence studies have reported differing background rates of Toxoplasma gondii infection in horses globally. The objective of this study was to evaluate possible associations between T. gondii...

Author(s)
James, K. E.; Smith, W. A.; Packham, A. E.; Conrad, P. A.; Pusterla, N.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Veterinary Journal, 2017, 224, pp 38-43
Abstract

Background: Infection by 2 or more protozoa is linked with increased severity of disease in marine mammals with protozoan encephalitis. Hypothesis/Objectives: To assess whether horses with equine protozoal myeloencephalitis (EPM) caused by Sarcocystis neurona also have evidence of infection with ...

Author(s)
Schale, S.; Howe, D.; Yeargan, M.; Morrow, J. K.; Graves, A.; Johnson, A. L.
Publisher
Wiley, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2018, 32, 3, pp 1210-1214
Abstract

Background: Accurate antemortem EPM diagnosis requires evidence of intrathecal antibody production. Some advocate the use of acute phase proteins in addition to serology, which alone results in substantial false positives. Hypothesis/Objectives: The purpose of this study was to determine if serum...

Author(s)
Mittelman, N. S.; Stefanovski, D.; Johnson, A. L.
Publisher
Wiley, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2018, 32, 5, pp 1726-1730
Abstract

The aim of this study was to compare two serologic tests used to support a diagnosis of equine protozoal myeloencephalitis (EPM). Serum and cerebrospinal fluid (CSF) samples were analyzed for antibodies to Sarcocystis neurona and Neospora hughesi by indirect fluorescent antibody testing (IFAT) and...

Author(s)
Renier, A. C.; Morrow, J. K.; Graves, A. J.; Finno, C. J.; Howe, D. K.; Owens, S. D.; Tamez-Trevino, E.; Packham, A. E.; Conrad, P. A.; Pusterla, N.
Publisher
Elsevier, New York, USA
Citation
Journal of Equine Veterinary Science, 2016, 36, pp 49-51
Abstract

Equine protozoal myeloencephalitis (EPM) is mainly caused by Sarcocystis neurona and generates significant economic losses. In Argentina, antibodies to this protozoan have been detected but no clinical cases have been reported. A 12 yearold mare, from Buenos Aires Province, presented asynchronous...

Author(s)
Moré, G.; Monina, M.; Girotti, G.; Idiart, J.; Venturini, L.; Venturini, M. C.
Publisher
Facultad de Ciencias Veterinarias, Universidad Nacional de la Plata, La Plata, Argentina
Citation
Analecta Veterinaria, 2019, 39, 1, pp 32-36
Abstract

Equine protozoal myeloencephalitis (EPM) is an important equine neurologic disorder, and treatments for the disease are often unrewarding. Prevention of the disease is the most important aspect for EPM, and a killed vaccine was previously developed for just that purpose. Evaluation of the vaccine...

Author(s)
Saville, W. J. A.; Dubey, J. P.; Marsh, A. E.; Reed, S. M.; Keene, R. O.; Howe, D. K.; Morrow, J.; Workman, J. D.
Publisher
Elsevier B.V., Amsterdam, Netherlands
Citation
Veterinary Parasitology, 2017, 247, pp 37-41
Abstract

Equine protozoal myeloencephalitis (EPM) remains an important neurologic disease of horses. There are no pathognomonic clinical signs for the disease. Affected horses can have focal or multifocal central nervous system (CNS) disease. EPM can be difficult to diagnose antemortem. It is caused by...

Author(s)
Reed, S. M.; Furr, M.; Howe, D. K.; Johnson, A. L.; MacKay, R. J.; Morrow, J. K.; Pusterla, N.; Witonsky, S.
Publisher
Wiley-Blackwell, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2016, 30, 2, pp 491-502
Abstract

Equine protozoal myeloencephalitis (EPM) can be caused by either of 2 related protozoan parasites, Sarcocystis neurona and Neospora hughesi, although S. neurona is the most frequent etiologic pathogen. Horses are commonly infected, but clinical disease occurs infrequently; the factors influencing...

Author(s)
Howe, D. K.; MacKay, R. J.; Reed, S. M.
Publisher
Elsevier Inc., New York, USA
Citation
Veterinary Clinics of North America, Equine Practice, 2014, 30, 3, pp 659-675
Abstract

Background: Ponazuril is used for the treatment of equine protozoal myeloencephalitis (EPM). Coadministration of ponazuril with oil could result in higher serum and cerebrospinal fluid (CSF) concentrations of ponazuril. Hypothesis: Coadministration of corn oil will result in higher serum and CSF...

Author(s)
Furr, M.; Kennedy, T.
Publisher
Wiley, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2020, 34, 3, pp 1321-1324
Abstract

Neurofilaments (NFs) are structural proteins of neurons that are released in significant quantities in the cerebrospinal fluid and blood as a result of neuronal degeneration or axonal damage. Therefore, NFs have potential as biomarkers for neurologic disorders. Neural degeneration increases with...

Author(s)
Gómez, A. M. M.; Zhu, S.; Palmer, S.; Olsen, E.; Ness, S. L.; Divers, T. J.; Bischoff, K.; Mohammed, H. O.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Research in Veterinary Science, 2019, 125, pp 1-6

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