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Abstract

Objective: To compare the effects of two different doses of butorphanol combined with detomidine administered intravenously (IV) on quality of sedation, degree of ataxia and anaesthetic induction in horses. Study design: Randomized, blinded, clinical study. Animals: A total of 40 client-owned...

Author(s)
Grauw, J. de; Loon, T. van
Publisher
Elsevier Ltd, Oxford, UK
Citation
Veterinary Anaesthesia and Analgesia, 2020, 47, 5, pp 681-685
Abstract

The anesthetic ketamine is often combined with analgesics and benzodiazepines in equine medicine. Therefore, drug-drug interactions are possible. Enzyme kinetics for ketamine N-demethylation were determined using equine CYP3A94, CYP3A95 and CYP3A97, and the effect of medetomidine, diazepam and...

Author(s)
Sandbaumhüter, F. A.; Vimercati, S.; Thormann, W.; Mevissen, M.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Toxicology in Vitro, 2018, 50, pp 242-248
Abstract

The effects of a standard protocol for euthanasia on heart rate variability (HRV) as a consequence of stress response were analyzed in this prospective clinical study. The HRV was determined in 40 horses undergoing euthanasia due to various reasons, at different locations, and with/without owner...

Author(s)
Gehlen, H.; Loschelder, J.; Merle, R.; Walther, M.
Publisher
MDPI AG, Basel, Switzerland
Citation
Animals, 2020, 10, 3,
Abstract

Research on drug metabolism and pharmacokinetics in large animal species including the horse is scarce because of the challenges in conducting in vivo studies. The metabolic reactions catalyzed by cytochrome P450s (CYPs) are central to drug pharmacokinetics. This study elucidated the...

Author(s)
Nakayama, S. M. M.; Ikenaka, Y.; Hayami, A.; Mizukawa, H.; Darwish, W. S.; Watanabe, K. P.; Kawai, Y. K.; Ishizuka, M.
Publisher
Wiley-Blackwell, Oxford, UK
Citation
Journal of Veterinary Pharmacology and Therapeutics, 2016, 39, 5, pp 478-487
Abstract

Background: Ketamine at 2.2 mg/kg given i.v. is often used to induce anaesthesia for surgical procedures in horses under field conditions. Commonly, additional doses are needed to complete the surgery. We hypothesised that surgical conditions would be improved when 5 mg/kg of ketamine was used to...

Author(s)
Hardardóttir, H.; Murison, P. J.; Blissitt, K.; Olason, S.; Clutton, R. E.
Publisher
Wiley, Oxford, UK
Citation
Equine Veterinary Journal, 2019, 51, 4, pp 458-463
Abstract

The study evaluated the effect of a 1/10 dose of flunixin meglumine administered into the governing vessel 1 (GV1) acupoint in horses that underwent castration. Twenty animals received 0.02 mg/kg detomidine intravenously, followed by 2.2 mg/kg ketamine and 0.1 mg/kg diazepam by the same route, and...

Author(s)
Reginato, G. M.; Xavier, N. V.; Alonso, B. B.; Lima, D. P.; Sirqueira, T. C. P.; Carregaro, A. B.
Publisher
Elsevier, New York, USA
Citation
Journal of Equine Veterinary Science, 2020, 87,
Abstract

Objective: To compare the effects of controlled mechanical ventilation (CMV) and constant positive end-expiratory pressure (PEEP) and interposed recruitment manoeuvres (RMs) with those of CMV without PEEP on gas exchange during general anaesthesia and the early recovery period. Study design:...

Author(s)
Hopster, K.; Rohn, K.; Ohnesorge, B.; Kästner, S. B. R.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Veterinary Anaesthesia and Analgesia, 2017, 44, 1, pp 121-126
AbstractFull Text

There is little information about drug metabolism and pharmacokinetics in horses. Therefore, it is necessary to characterize the profiles of drug metabolites for the safe use of drugs. In this study, we focused on cytochrome P450 enzymes (CYPs), which represent an important enzyme group to...

Author(s)
Hayami, A.; Darwish, W. S.; Ikenaka, Y.; Nakayama, S. M. M.; Ishizuka, M.
Publisher
Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
Citation
Japanese Journal of Veterinary Research, 2013, 61, Suppl., pp S82-S84
Abstract

A 550 kg Thoroughbred broodmare born in 2007 was evaluated repeatedly over five breeding seasons because of episodic seizures, which occurred only after vaccination. The mare had no health problems other than repetitive reactive, focal seizures that occurred over a 5-year period, in each case after ...

Author(s)
Barros, T.; Moran, G.; Uberti, B.
Publisher
Elsevier, New York, USA
Citation
Journal of Equine Veterinary Science, 2019, 73, pp 106-109
Abstract

A 6-year-old 559-kg Canadian Warmblood mare with lacerations over the neck and all four limbs was presented to the Western College Veterinary Medicine. Medical treatment and wound lavage was carried out for 5 days with no clinical improvement. Ultrasonography of the gluteal region showed disruption ...

Author(s)
Carrozzo, M. V.; Ambros, B.
Publisher
BMJ Publishing Group, London, UK
Citation
Veterinary Record Case Reports, 2020, 8, 1,

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