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Abstract

Background: Mild equine asthma is a common inflammatory airway disease of the horse. The primary treatment of mild equine asthma is corticosteroids. The purpose of this study was to investigate the effects of injected dexamethasone on relative IL-1β, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12p35, IL-17,...

Author(s)
Bond, S. L.; Hundt, J.; Léguillette, R.
Publisher
BioMed Central Ltd, London, UK
Citation
BMC Veterinary Research, 2019, 15, 397, pp (06 November 2019)
Abstract

Therapeutic agents capable of altering the performance of horses are monitored in racing and equestrian sports to guarantee horse welfare, fair competition, and integrity of the sport. Dexamethasone is a common glucocorticoid drug for treating horses. Among other effects, dexamethasone is...

Author(s)
Ekstrand, C.; Falkenö, U.; Kallings, P.; Tvedten, H.; Lilliehöök, I.
Publisher
Elsevier, New York, USA
Citation
Journal of Equine Veterinary Science, 2019, 73, pp 75-80
Abstract

Background: Inhaled corticosteroids are effective in the treatment of equine asthma. A recent study reported that nebulisation of injectable dexamethasone had low systemic bioavailability in healthy horses and could represent a cost-effective therapy for equine inflammatory lung diseases....

Author(s)
Mainguy-Seers, S.; Bessonnat, A.; Picotte, K.; Lavoie, J. P.
Publisher
Wiley, Oxford, UK
Citation
Equine Veterinary Journal, 2019, 51, 5, pp 641-645
Abstract

Background: Dexamethasone is used for the intra-articular route of administration in management of aseptic arthritis in horses. Despite its widespread use there is very little quantitative data of the disposition and response to dexamethasone. The aim of this study was to investigate and describe...

Author(s)
Ekstrand, C.; Bondesson, U.; Giving, E.; Hedeland, M.; Ingvast-Larsson, C.; Jacobsen, S.; Löfgren, M.; Moen, L.; Rhodin, M.; Saetra, T.; Ranheim, B.
Publisher
BioMed Central Ltd, London, UK
Citation
Acta Veterinaria Scandinavica, 2019, 61, 28, pp (20 June 2019)
Abstract

Objective: To quantify the time to clear dexamethasone from plasma and urine of horses following a single nebulisation. Design: Experimental using six Standardbred mares. Methods: Dexamethasone sodium phosphate (0.04 mg/kg) diluted in 0.9% sodium chloride was administered as an aerosol using a...

Author(s)
Symonds, N. E.; Dart, A. J.; Keledjian, J.; Lau, M. L.; Ennis, L. C.; McIver, V. C.; Tsang, A. S.; Biasutti, S. A.; Jeffcott, L. B.
Publisher
Wiley, Melbourne, Australia
Citation
Australian Veterinary Journal, 2019, 97, 5, pp 144-148
Abstract

Background: Corticosteroids are the most potent drugs for the control of severe equine asthma, but adverse effects limit their chronic systemic administration. Inhaled medications allow for drug delivery directly into the airways, reducing the harmful effects of these drugs. Objectives: To evaluate ...

Author(s)
Lavoie, J. P.; Leclere, M.; Rodrigues, N.; Lemos, K. R.; Bourzac, C.; Lefebvre-Lavoie, J.; Beauchamp, G.; Albrecht, B.
Publisher
Wiley, Oxford, UK
Citation
Equine Veterinary Journal, 2019, 51, 3, pp 401-407
Abstract

Background: Nebulisation of the injectable dexamethasone sodium phosphate (DSP) would offer an inexpensive way of delivering a potent corticosteroid directly to the lungs of horses with asthma. However, this approach would be advantageous only if systemic absorption is minimal and if the...

Author(s)
Haspel, A. D.; Giguère, S.; Hart, K. A.; Berghaus, L. J.; Davis, J. L.
Publisher
Wiley, Oxford, UK
Citation
Equine Veterinary Journal, 2018, 50, 1, pp 85-90
Abstract

Background: Blood lactate concentration is a marker of tissue perfusion and helps guide therapeutic interventions in critically ill horses. In both humans and dogs, administration of corticosteroids can increase blood lactate concentration, leading to type B hyperlactatemia. This effect could be a...

Author(s)
Mizen, K.; Woodman, J.; Boysen, S. R.; Wagg, C.; Greco-Otto, P.; Léguillette, R.; Roy, M. F.
Publisher
Wiley, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2017, 31, 1, pp 164-169
Abstract

Background: Prolonged exposure to environmental antigens or allergens elicits an immune response in both healthy horses and those with mild asthma. Corticosteroids often are used to treat lower airway inflammation. Objective: To investigate the changes in equine herpesvirus (EHV)-1,2,4,5...

Author(s)
Bond, S. L.; Workentine, M.; Hundt, J.; Gilkerson, J. R.; Léguillette, R.
Publisher
Wiley, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2020, 34, 1, pp 307-321
Abstract

Equine asthma is the current terminology that covers chronic non-infectious lower airway disorders in the horse. Mild and moderate equine asthma reflect the syndrome previously referred to as inflammatory airway disease, while severe asthma reflects both recurrent airway obstruction and summer...

Author(s)
Bailey, J.; Bowen, M.
Publisher
MA Healthcare Limited, London, UK
Citation
UK-Vet Equine, 2020, 4, 1, pp 19-29

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