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Abstract

Equine degenerative myeloencephalopathy (EDM), a neurological disease of young horses, causes progressive development of symmetric ataxia predominantly in the pelvic limbs. Equine degenerative myeloencephalopathy is likely inherited and with no known treatment affected horses frequently need...

Author(s)
Posbergh, C. J.; Pollott, G. E.; Southard, T. L.; Divers, T. J.; Brooks, S. A.
Publisher
Elsevier, New York, USA
Citation
Journal of Equine Veterinary Science, 2018, 70, pp 96-100
Abstract

Objective: A pigment retinopathy has been reported in adult horses with equine motor neuron disease (EMND) arising from chronic α-tocopherol (α-TP) deficiency. A pigment retinopathy has not been identified in horses with neuroaxonal dystrophy/equine degenerative myeloencephalopathy (NAD/EDM) that...

Author(s)
Finno, C. J.; Kaese, H. J.; Miller, A. D.; Gianino, G.; Divers, T.; Valberg, S. J.
Publisher
Wiley, Boston, USA
Citation
Veterinary Ophthalmology, 2017, 20, 4, pp 304-309
Abstract

Equine degenerative myeloencephalopathy (EDM) is characterized by a symmetric general proprioceptive ataxia in young horses, and is likely underdiagnosed for 2 reasons: first, clinical signs overlap those of cervical vertebral compressive myelopathy; second, histologic lesions - including axonal...

Author(s)
Finno, C. J.; Valberg, S. J.; Shivers, J.; D'Almeida, E.; Armién, A. G.
Publisher
American College of Veterinary Pathologists Inc., Lawrence, USA
Citation
Veterinary Pathology, 2016, 53, 1, pp 77-86
Abstract

The cervical spinal cords of 2 horses with equine degenerative myeloencephalopathy (EDM) were evaluated for evidence of oxidative damage to the central nervous system (CNS) using immunohistochemical staining for 3-nitrotyrosine (3-NT) and 4-hydroxynonenol (4-HNE). Neurons of the CNS from horses...

Author(s)
Wong, D. M.; Ghosh, A.; Fales-Williams, A. J.; Haynes, J. S.; Kanthasamy, A. G.
Publisher
American College of Veterinary Pathologists Inc., Lawrence, USA
Citation
Veterinary Pathology, 2012, 49, 6, pp 1049-1053
Abstract

Background: Equine neuroaxonal dystrophy/equine degenerative myeloencephalopathy (eNAD/EDM) is a neurodegenerative disorder affecting genetically predisposed foals maintained on an α-tocopherol (α-TOH) deficient diet. Currently no antemortem diagnostic test for eNAD/EDM is available. Hypothesis:...

Author(s)
Finno, C. J.; Estell, K. E.; Winfield, L.; Katzman, S.; Bordbari, M. H.; Burns, E. N.; Miller, A. D.; Puschner, B.; Tran, C. K.; Xu LiBin
Publisher
Wiley, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2018, 32, 5, pp 1740-1747
Abstract

Background: Equine degenerative myeloencephalopathy (EDM) is a neurodegenerative disorder that has been previously associated with low vitamin E concentrations. Objective: To describe the clinical, electrophysiologic, and pathologic features of EDM in a group of related Lusitano horses. Animals:...

Author(s)
Finno, C. J.; Higgins, R. J.; Aleman, M.; Ofri, R.; Hollingsworth, S. R.; Bannasch, D. L.; Reilly, C. M.; Madigan, J. E.
Publisher
Wiley-Blackwell, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2011, 25, 6, pp 1439-1446
Abstract

Background: Equine neuroaxonal dystrophy/equine degenerative myeloencephalopathy (NAD/EDM) is a neurodegenerative disorder affecting genetically predisposed foals maintained on α-tocopherol (α-TP)-deficient diet. Objective: Intramuscular α-TP and selenium (Se) administration at 4 days of age would...

Author(s)
Finno, C. J.; Estell, K. E.; Katzman, S.; Winfield, L.; Rendahl, A.; Textor, J.; Bannasch, D. L.; Puschner, B.
Publisher
Wiley-Blackwell, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2015, 29, 6, pp 1667-1675
Abstract

Background: Equine neuroaxonal dystrophy/equine degenerative myeloencephalopathy (NAD/EDM) is a neurodegenerative disorder affecting young horses of various breeds that resembles ataxia with vitamin E deficiency in humans, an inherited disorder caused by mutations in the alpha-tocopherol transfer...

Author(s)
Finno, C. J.; Famula, T.; Aleman, M.; Higgins, R. J.; Madigan, J. E.; Bannasch, D. L.
Publisher
Wiley-Blackwell, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2013, 27, 1, pp 177-185
Abstract

Objective: Neuroaxonal dystrophy (NAD) is a disease characterized by the sudden onset of neurologic signs in horses ranging from 4 to 36 months of age. Equine degenerative myeloencephalopathy (EDM), a disease that has been associated with low vitamin E concentrations, is considered a more advanced...

Author(s)
Finno, C. J.; Aleman, M.; Ofri, R.; Hollingsworth, S. R.; Madigan, J. E.; Winfield, L.; Bannasch, D. L.
Publisher
Wiley-Blackwell, Oxford, UK
Citation
Veterinary Ophthalmology, 2012, 15, s2, pp 3-7
Abstract

Equine neuroaxonal dystrophy/equine degenerative myeloencephalopathy is an inherited neurodegenerative disorder affecting many horse breeds. Clinical signs include a symmetric ataxia and an abnormal stance at rest, similar to cervical vertebral compressive myelopathy, equine protozoal...

Author(s)
Burns, E. N.; Finno, C. J.
Publisher
Dove Medical Press Ltd, Macclesfield, UK
Citation
Veterinary Medicine: Research and Reports, 2018, 9, pp 63-67

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