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Abstract

β2-adrenoceptor agonists are considered the most effective drugs to counteract bronchoconstriction in horses with asthma, but only clenbuterol is commonly employed in clinical practice. We evaluated the effects of different selective β2 agonists: clenbuterol, ritodrine, salbutamol, and fenoterol on ...

Author(s)
Pozzoli, C.; Bertini, S.; Poli, E.; Placenza, G.; Menozzi, A.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Research in Veterinary Science, 2020, 128, pp 43-48
Abstract

Background: Clenbuterol, a beta2-adrenergic receptor agonist, is used therapeutically to treat respiratory conditions in the horse. However, by virtue of its mechanism of action it has been suggested that clenbuterol may also have repartitioning affects in horses and as such the potential to affect ...

Author(s)
Knych, H. K.; Harrison, L. M.; Steinmetz, S. J.; Chouicha, N.; Kass, P. H.
Publisher
BioMed Central Ltd, London, UK
Citation
BMC Genomics, 2016, 17, 596, pp (9 August 2016)
Abstract

Chronic pulmonary disease alters skeletal muscle in humans and horses. The purpose of this study was to evaluate a possible effect of the β2-sympathomimetic agent clenbuterol, known for its bronchodilatory and anabolic effects on skeletal musculature, on mitochondrial activity and histopathologic...

Author(s)
Gehlen, H.; Stave, C.; Bilzer, T.; Stadler, P.
Publisher
Hippiatrika Verlag GmbH, Baden-Baden, Germany
Citation
Pferdeheilkunde, 2015, 31, 1, pp 4-10
Abstract

OBJECTIVE: To determine the anabolic and lipolytic effects of a low dosage of clenbuterol administered orally in working and nonworking equids. ANIMALS: 8 nonworking horses and 47 polo ponies in active training. PROCEDURES: Each polo pony continued training and received either clenbuterol (0.8...

Author(s)
Nolen-Walston, R. D.; Moore, C. M.; Barr, C. A.; Tomlinson, J. E.; Boston, R. C.; Soma, L. R.
Publisher
American Veterinary Medical Association, Schaumburg, USA
Citation
American Journal of Veterinary Research, 2015, 76, 5, pp 460-466
Abstract

Reasons for performing study: The use of clenbuterol in performance horses necessitates the establishment of appropriate withdrawal times. Objectives: To describe plasma and urine concentrations of clenbuterol following administration of 2 commonly used dosing regimens to racing fit Thoroughbreds....

Author(s)
Knych, H. K.; Mitchell, M. M.; Steinmetz, S. J.; McKemie, D. S.
Publisher
Wiley-Blackwell, Oxford, UK
Citation
Equine Veterinary Journal, 2014, 46, 3, pp 380-385
Abstract

The final destination of the large volumes of horse meat produced in Mexico is not apparent. The current study therefore aimed to determine if horse meat is sold fraudulently under the guise of beef in Mexico and the levels of clenbuterol residues in samples. While more than a quarter of the...

Author(s)
Rubio Lozano, M. S.; Hernández Chávez, J. F.; Ruíz López, F. A.; Medina Medina, R.; Delgado Suárez, E.; Méndez Medina, R. D.; Ngapo, T. M.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Food Control, 2020, 110, pp 107028
Abstract

The cardiac effect of the beta-2 sympathomimetic drug clenbuterol at a therapeutic dose (0.8 µg/kg, twice daily), administered over a period of 14 days, was investigated by the sensitive method of tissue Doppler echocardiography. The group of 45 investigated horses consisted of 25 with healthy...

Author(s)
Neukirch, S.
Publisher
Freie Universität Berlin, Berlin, Germany
Citation
Gewebedopplerechokardiographische Untersuchung der Wirkung des <Beta>2-Sympathomimetikums Clenbuterol auf den Herzmuskel gesunder und an RAO erkrankter Pferde, 2011, pp xii + 199 pp.
Abstract

Cardiac effects of the β2-adrenergic agent clenbuterol have been the focus of many studies, but effects on myocardial velocities and myocardial deformation parameters have not yet been evaluated in horses affected with recurrent airway obstruction (RAO) using tissue Doppler imaging (TDI) and...

Author(s)
Heidrun, G.; Susanne, N.
Publisher
Elsevier, New York, USA
Citation
Journal of Equine Veterinary Science, 2014, 34, 4, pp 471-478
Abstract

Objectives: To determine whether the β-adrenergic agonist, clenbuterol hydrochloride, was able to inhibit leukocyte production of Interleukin-1β (IL-1β) and Tumor Necrosis Factor a (TNFα) after ex vivo stimulation of equine blood leukocytes with bacterial toxins from Gram-positive as well as...

Author(s)
Cudmore, L.; Whittem, T.; Bailey, S. R.
Publisher
Australian Veterinary Association (N.S.W) Division, Artarmon, Australia
Citation
Australian Equine Veterinarian, 2015, 34, 2, pp 38-42
Abstract

Pro-inflammatory cytokines, such as IL-1β and TNFα, play a major role in activating leukocytes and endothelial cells during the systemic inflammatory response to endotoxin in the horse. β2 agonist drugs, such as clenbuterol, inhibit leukocyte activation. This study aimed to determine the effects of ...

Author(s)
Cudmore, L. A.; Muurlink, T.; Whittem, T.; Bailey, S. R.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Research in Veterinary Science, 2013, 94, 3, pp 682-686

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