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Abstract

Several studies have dealt with the etiopathogenesis-, diagnostics as well as the conservative and surgical treatment methods of equine recurrent uveitis (ERU) with different outcomes. Because of potential side effects of applied medication, the risk of doping in the case of sport horses and the...

Author(s)
Waid, H.; Tóth, J.; Buijs, L.; Schusser, G. F.
Publisher
Hippiatrika Verlag GmbH, Baden-Baden, Germany
Citation
Pferdeheilkunde, 2018, 34, 2, pp 113-120
Abstract

An 8-year-old mare was presented for investigation of a 1-month history of blepharospasm, eyelid swelling, corneal edema, and ocular discharge of the right eye (OD). Ophthalmic examination confirmed mucopurulent ocular discharge, conjunctival hyperemia, and a dry, dull appearance to the cornea OD....

Author(s)
Mackenzie, C. J.; Carslake, H. B.; Robin, M.; Kent, R. J.; Malalana, F.
Publisher
Wiley, Boston, USA
Citation
Veterinary Ophthalmology, 2017, 20, 1, pp 79-83
Abstract

Purpose: To describe the use of episcleral silicone matrix cyclosporine (ESMC) drug delivery devices in horses with immune-mediated keratitis (IMMK) with evaluation of tolerability and efficacy in long-term control of inflammation. Methods: Retrospective study. ESMC implants (1.2 cm length, 30%...

Author(s)
Gilger, B. C.; Stoppini, R.; Wilkie, D. A.; Clode, A. B.; Pinto, N. H.; Hempstead, J.; Gerding, J.; Salmon, J. H.
Publisher
Wiley-Blackwell, Oxford, UK
Citation
Veterinary Ophthalmology, 2014, 17, s1, pp 23-30
Abstract

The present case report describes the treatment of a horse suffering from equine recurrent uveitis. The surgical treatment performed with a suprachoroidal cyclosporin-A implant did not prevent the subsequent ocular inflammation. In addition, a few days after installation, an intraocular implant...

Author(s)
Buijs, L.; Tóth, J.
Publisher
Schlütersche Verlagsgesellschaft GmbH & Co. KG, Hannover, Germany
Citation
Praktische Tierarzt, 2018, 99, 3, pp 278-285
Abstract

Background: Despite appropriate medical therapy, many horses with equine recurrent uveitis continue to suffer from recurrent bouts of inflammation. Surgical intervention via the pars plana vitrectomy or suprachoroidal cyclosporine implant placement may control and/or prevent recurrences, however,...

Author(s)
Fischer, B. M.; McMullen, R. J.; Reese, S.; Brehm, W.
Publisher
BioMed Central Ltd, London, UK
Citation
BMC Veterinary Research, 2019, 15, 29, pp (16 January 2019)
Abstract

A 19-year-old Dutch Warmblood mare was referred for the evaluation of acute corneal edema of the right eye. Ophthalmic examination revealed a vertical band of corneal edema and precipitates were visible on the endothelium. The pupil was miotic. Intraocular pressure was 15 mm Hg compared to 19 mm Hg ...

Author(s)
Hermans, H.; Ensink, J. M.
Publisher
Hippiatrika Verlag GmbH, Stuttgart, Germany
Citation
Pferdeheilkunde, 2013, 29, 6, pp 712-715
Abstract

Cyclosporine A (CsA) is a potent immunosuppressive drug which is used in the therapy of equine recurrent uveitis (ERU) in form of a suprachoroidal CsA-implant which achieves high drug concentrations in the vitreous. This should be particularly effective in the Appaloosa horse which shows a special...

Author(s)
Baumgart, A.; Gerhards, H.
Publisher
Hippiatrika Verlag GmbH, Baden-Baden, Germany
Citation
Pferdeheilkunde, 2014, 30, 6, pp 626...632
Abstract

The purpose of this study was to determine the efficacy and duration of effect of a subscleral cyclosporine A implant in horses with immune-mediated keratitis (IMMK). The study at hand describes the cases of fifteen horses with mature IMMK that were presented to the Tierklinik Hochmoor for further...

Author(s)
Tóth, J.; Huthmann, S.; Hollerrieder, J.
Publisher
Hippiatrika Verlagsgesellschaft mbH, Stuttgart, Germany
Citation
Pferdeheilkunde, 2011, 27, 6, pp 589...596
Abstract

Previously, the cyclophilin inhibitors cyclosporine (CsA) and alisporivir (ALV) were shown to inhibit the replication of diverse RNA viruses, including arteriviruses and coronaviruses, which both belong to the order Nidovirales. In this study, we aimed to identify arterivirus proteins involved in...

Author(s)
Wilde, A. H. de; Boomaars-van der Zanden, A. L.; Jong, A. W. M. de; Bárcena, M.; Snijder, E. J.; Posthuma, C. C.
Publisher
American Society for Microbiology (ASM), Washington, D.C., USA
Citation
Journal of Virology, 2019, 93, 18, pp e00490-19
Abstract

Bats are primary reservoirs for multiple lethal human viruses, such as Ebola, Nipah, Hendra, rabies, severe acute respiratory syndrome coronavirus (SARSCoV), Middle East respiratory syndrome-related coronavirus (MERS-CoV), and, most recently, SARS-CoV-2. The innate immune systems of these immensely ...

Author(s)
Morrison, J. H.; Miller, C.; Bankers, L.; Crameri, G.; Wang LinFa; Poeschla, E. M.
Publisher
American Society for Microbiology (ASM), Washington, D.C., USA
Citation
mBio, 2020, 11, 5,

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