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Abstract

To the authors' knowledge, there have been no studies evaluating the pharmacokinetics of chloramphenicol administered orally to horses at the currently recommended dose of 50 mg/kg PO q6 h for multiple days. The published antimicrobial susceptibility breakpoint is 8.0 ug/mL; it is unknown if this...

Author(s)
Estell, K. E.; Knych, H. K.; Patel, T.; Edman, J. M.; Magdesian, K. G.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Veterinary Journal, 2020, 257,
Abstract

Chloramphenicol is commonly used in horses; however, there are no studies evaluating the pharmacokinetics of veterinary canine-approved tablets. Studies using different formulations and earlier analytical techniques led to concerns over low bioavailability in horses. Safety concerns about human...

Author(s)
Trishna Patel; Magdesian, K. G.; Estell, K. E.; Edman, J. M.; Knych, H. K.
Publisher
Wiley, Oxford, UK
Citation
Journal of Veterinary Pharmacology and Therapeutics, 2019, 42, 6, pp 609-616
Abstract

OBJECTIVE: To determine the pharmacokinetics of chloramphenicol base after PO administration at a dose of SO mg/kg (22.7 mg/lb) in adult horses from which food was not withheld. DESIGN: Prospective crossover study. ANIMALS: 5 adult mares. PROCEDURES: Chloramphenicol base (SO mg/kg) was administered ...

Author(s)
McElligott, E. M.; Sommardahl, C. S.; Cox, S. K.
Publisher
American Veterinary Medical Association, Schaumburg, USA
Citation
Journal of the American Veterinary Medical Association, 2017, 251, 1, pp 90-94
Abstract

Purpose: To identify temporal changes in antimicrobial resistance of ocular surface bacteria isolated from clinically symptomatic equine eyes in the South West of the UK. Study design Retrospective. Methods: Clinical and laboratory records of horses treated for suspected bacterial ocular surface...

Author(s)
Chalder, R. H.; Knott, T.; Rushton, J. O.; Nikolic-Pollard, D.
Publisher
Wiley, Boston, USA
Citation
Veterinary Ophthalmology, 2020, 23, 6, pp 950-956
Abstract

A 7-year-old American Quarter Horse gelding was referred to the JT Vaughan Large Animal Teaching Hospital at Auburn University, College of Veterinary Medicine, for an investigation of a recurrent swelling of the nasofrontal region. Computed tomography examination of the skull was most consistent...

Author(s)
Boorman, S.; Boone, L.; Weatherall, K.; Caldwell, F.
Publisher
Elsevier, New York, USA
Citation
Journal of Equine Veterinary Science, 2020, 91,
Abstract

Horses are exposed to various kinds of medication, however, there are limited determinations of plasma clearance (CLp) for the drugs used due to the high cost of equine in vivo studies. Many of the CLp values generated come from the equine sports industry for determining drug plasma screening...

Author(s)
Shibany, K. A.; Pratt, S. L.; Aldurdunji, M.; Totemeyer, S.; Paine, S. W.
Publisher
Taylor & Francis, Abingdon, UK
Citation
Xenobiotica, 2020, 50, 10, pp 1220-1227
Abstract

We aimed to investigate the prevalence, molecular characteristics and risk factors of extended-spectrum -lactamase (ESBL)-producing Enterobacteriaceae (ESBL-E) shedding in horses. A prospective study included three cohorts: (i) farm horses (13 farms, n = 192); (ii) on hospital admission (n = 168)...

Author(s)
Shnaiderman-Torban, A.; Navon-Venezia, S.; Dor, Z.; Paitan, Y.; Arielly, H.; Wiessam Abu Ahmad; Kelmer, G.; Fulde, M.; Steinman, A.
Publisher
MDPI AG, Basel, Switzerland
Citation
Animals, 2020, 10, 2,
Abstract

In this study, we investigated the occurrence of antimicrobial resistance in commensal Escherichia coli isolated from healthy Thoroughbred (TB) racehorses in Japan. A total of 212 fecal samples were individually collected from TB racehorses from March 2017 to August 2018 at Japan Racing Association ...

Author(s)
Sato, W.; Sukmawinata, E.; Uemura, R.; Kanda, T.; Kusano, K.; Kambayashi, Y.; Sato, T.; Ishikawa, Y.; Toya, R.; Sueyoshi, M.
Publisher
Japanese Society of Equine Science (Nihon Uma Kagakukai) Equine Research Institute, Japan Racing Association, Utsunomiya, Japan
Citation
Journal of Equine Science, 2020, 31, 4, pp 85-91
Abstract

Salmonella enterica is a highly infectious microorganism responsible for many outbreaks reported in equine hospitals. Outbreaks are characterized by high morbidity and mortality rates, nosocomial transmission to other patients, zoonotic transmission to hospital personnel, and even closure of...

Author(s)
Soza-Ossandón, P.; Rivera, D.; Tardone, R.; Riquelme-Neira, R.; García, P.; Hamilton-West, C.; Adell, A. D.; González-Rocha, G.; Moreno-Switt, A. I.
Publisher
Frontiers Media S.A., Lausanne, Switzerland
Citation
Frontiers in Veterinary Science, 2020, 6, July,
Abstract

Regional limb perfusion (RLP) significantly decreases morbidity and mortality associated with distal limb injuries in horses. There is an urgent need for finding additional effective antimicrobial drugs for use in RLP. In this study, we tested the pharmacokinetics (PK) of chloramphenicol in RLP....

Author(s)
Kelmer, G.; Tatz, A. J.; Famini, S.; Bdolah-Abram, T.; Soback, S.; Britzi, M.
Publisher
Wiley-Blackwell, Oxford, UK
Citation
Journal of Veterinary Pharmacology and Therapeutics, 2015, 38, 1, pp 35-40

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