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Abstract

Cerebellar Abiotrophy (CA) is a neurodegenerative disease in Arabian horses affecting the cerebellum, more specifically the Purkinje neurons. Although CA occurs in several domestic species, CA in Arabian horses is unique in that a single nucleotide polymorphism (SNP) has been associated with the...

Author(s)
Scott, E. Y.; Woolard, K. D.; Finno, C. J.; Penedo, M. C. T.; Murray, J. D.
Publisher
Elsevier Science Publishers B.V, Biomedical Division, Amsterdam, Netherlands
Citation
Brain Research, 2018, 1678, pp 330-336
Abstract

The highly selective breeding of Arabian horses results in inbreeding depression and genetic disorders, thereby causing significant economic loss. The Polish population of Arabians has a great impact on many breeding programmes. The aim of the current study was to monitor genetic variants involved...

Author(s)
Bugno-Poniewierska, M.; Stefaniuk-Szmukier, M.; Piestrzyńska-Kajtoch, A.; Fornal, A.; Piórkowska, K.; Ropka-Molik, K.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Veterinary Journal, 2019, 248, pp 71-73
Abstract

Background: Cerebellar abiotrophy (CA) is a rare but significant disease in Arabian horses caused by progressive death of the Purkinje cells resulting in cerebellar ataxia characterized by a typical head tremor, jerky head movements and lack of menace response. The specific role of magnetic...

Author(s)
Cavalleri, J. M. V.; Metzger, J.; Hellige, M.; Lampe, V.; Stuckenschneider, K.; Tipold, A.; Beineke, A.; Becker, K.; Distl, O.; Feige, K.
Publisher
BioMed Central Ltd, London, UK
Citation
BMC Veterinary Research, 2013, 9, 105, pp (23 May 2013)
AbstractFull Text

Cerebellar abiotrophy (CA) is a neurodegenerative disease caused by a mutation in the DNA that affects the Purkinje cells of the cerebellum, mainly causing problems in the balance and coordination of animals. Among the species that are affected is equine, mainly the Arabian breed. In this study we...

Author(s)
Gagliardi, R.; León, L. de; Catania, C.; Ghiringhelli, C.; Llambí, S.
Publisher
Sociedad de Medicina Veterinaria del Uruguay, Montevideo, Uruguay
Citation
Veterinaria (Montevideo), 2018, 54, 210, pp 43-45
AbstractFull Text

Evidence of cerebellar abiotrophy (CA) was found in a six-month-old Arabian filly with signs of incoordination, head tremor, wobbling, loss of balance and falling over, consistent with a cerebellar lesion. Normal hematology profile blood test and cerebrospinal fluid analysis excluded infectious...

Author(s)
Sadaba, S. A.; Madariaga, G. J.; Corbi Botto, C. M.; Carino, M. H.; Zappa, M. E.; Peral García, P.; Olguín, S. A.; Massone, A.; Díaz, S.
Publisher
Faculty of Veterinary Medicine, University of Tripoli, Tripoli, Libya
Citation
Open Veterinary Journal, 2016, 6, 3, pp 259-262
Abstract

Reasons for performing study: A putative mutation causative of cerebellar abiotrophy (CA), a genetic defect found almost exclusively in Arabian horses, was recently identified. Objectives and hypothesis: To investigate the presence of the CA mutation in breeds other than Arabian and ascertain...

Author(s)
Brault, L. S.; Penedo, M. C. T.
Publisher
Wiley-Blackwell, Oxford, UK
Citation
Equine Veterinary Journal, 2011, 43, 6, pp 727-731
Abstract

Cerebellar abiotrophy (CA) is an uncommon neurological disease that most commonly affects Arabian horses. Affected horses are typically identified within the first 6 months of life. Intention tremor, wide based stance and ataxia are common clinical signs observed in affected individuals. No...

Author(s)
Foley, A.; Grady, J.; Almes, K.; Patton, K.; Davis, E.
Publisher
Wiley-Blackwell, Oxford, UK
Citation
Equine Veterinary Education, 2011, 23, 3, pp 130-134
Abstract

Background: The carrier status of lavender foal syndrome (LFS), cerebellar abiotrophy (CA), severe combined immunodeficiency (SCID), and occipitoatlantoaxial malformation (OAAM1) in foals with juvenile idiopathic epilepsy (JIE) is unknown. Hypothesis/Objectives: To determine the carrier status of...

Author(s)
Aleman, M.; Finno, C. J.; Weich, K.; Penedo, M. C. T.
Publisher
Wiley, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2018, 32, 1, pp 465-468
Abstract

Objective - To determine the mode of inheritance for cerebellar abiotrophy (CA), a neurologic disease in Arabians. Animals - 804 Arabians, including 29 horses (15 males and 14 females) with CA. Procedures - Most horses (n=755) belonged to 1 of 4 paternal families. Among the 29 CA-affected horses,...

Author(s)
Brault, L. S.; Famula, T. R.; Penedo, M. C. T.
Publisher
American Veterinary Medical Association, Schaumburg, USA
Citation
American Journal of Veterinary Research, 2011, 72, 7, pp 940-944
Abstract

Equine Cerebellar Abiotrophy (CA) is a neurological disease found in Arabian horses. CA is characterized by post-natal degeneration of the Purkinje cells of the cerebellum. Signs of CA include ataxia, head tremors, and a lack of balance equilibrium. We have discovered a linkage of the CA phenotype...

Author(s)
Brault, L. S.; Cooper, C. A.; Famula, T. R.; Murray, J. D.; Penedo, M. C. T.
Publisher
Elsevier Academic Press, San Diego, USA
Citation
Genomics (San Diego), 2011, 97, 2, pp 121-129

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