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Abstract

Objective: To investigate the pharmacological profile and side effects of buprenorphine administered as a sustained-release formulation in horses. Study design: Pilot trial. Animals: A total of four experimental horses, aged 18-27 years and weighing 508-578 kg. Methods: Buprenorphine (0.1 mg kg-1)...

Author(s)
Levionnois, O. L.; Graubner, C.; Spadavecchia, C.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Veterinary Anaesthesia and Analgesia, 2018, 45, 6, pp 876-880
Abstract

Objective: Describe the pharmacokinetics of buprenorphine and norbuprenorphine in horses and to relate the plasma buprenorphine concentration to the pharmacodynamic effects. Study design: Single phase non-blinded study. Animals: Six dedicated research horses, aged 3-10 years and weighing 480-515...

Author(s)
Love, E. J.; Pelligand, L.; Taylor, P. M.; Murrell, J. C.; Sear, J. W.
Publisher
Wiley-Blackwell, Oxford, UK
Citation
Veterinary Anaesthesia and Analgesia, 2015, 42, 1, pp 17-29
Abstract

Objective: To compare sedative and analgesic properties of buprenorphine or morphine for standing procedures combined with a detomidine continuous rate infusion (CRI). Study design: Blinded, prospective, randomized clinical pilot study. Animals: Ten horses presented for dental or sinus procedures....

Author(s)
Potter, J. J.; MacFarlane, P. D.; Love, E. J.; Tremaine, H.; Taylor, P. M.; Murrell, J. C.
Publisher
Wiley-Blackwell, Oxford, UK
Citation
Veterinary Anaesthesia and Analgesia, 2016, 43, 2, pp 189-194
Abstract

Reasons for performing study: Buprenorphine, a µ-agonist opioid, has recently been licensed for equine use, but butorphanol, a κ-agonist opioid, is more commonly used in horses. The effect of the 2 opioids has not previously been compared in a large clinical study. Objectives: To compare post...

Author(s)
Taylor, P. M.; Hoare, H. R.; Vries, A. de; Love, E. J.; Coumbe, K. M.; White, K. L.; Murrell, J. C.
Publisher
Wiley-Blackwell, Oxford, UK
Citation
Equine Veterinary Journal, 2016, 48, 4, pp 442-450
Abstract

Objective: To elicit and evaluate the NWR (nociceptive withdrawal reflex) in 2 and 11 day old foals, to investigate if buprenorphine causes antinociception and determine if the NWR response changes with increasing age. The effect of buprenorphine on behaviour was also evaluated. Study design:...

Author(s)
Risberg, Å. I.; Spadavecchia, C.; Ranheim, B.; Hendrickson, E. H. S.; Lervik, A.; Haga, H. A.
Publisher
Wiley-Blackwell, Oxford, UK
Citation
Veterinary Anaesthesia and Analgesia, 2015, 42, 3, pp 329-338
Abstract

Buprenorphine is absorbed following sublingual administration, which would be a low-stress delivery route in foals. However, the pharmacokinetics/pharmacodynamics are not described in foals. Six healthy foals <21 days of age participated in a blinded, randomized, 3-period, 5-sequence, 3-treatment crossover prospective study. Foals received 0.01-0.02 mg/kg buprenorphine administered SL or IV with an equivalent volume of saline administered by...

Author(s)
Grubb, T. L.; Kurkowski, D.; Sellon, D. C.; Seino, K. K.; Coffey, T.; Davis, J. L.
Publisher
Wiley, Oxford, UK
Citation
Journal of Veterinary Pharmacology and Therapeutics, 2019, 42, 1, pp 26-36
Abstract

Reasons for performing study: To investigate the antinociceptive effects of buprenorphine administered in combination with acepromazine in horses and to establish an effective dose for use in a clinical environment. Objectives: To evaluate the responses to thermal and mechanical stimulation...

Author(s)
Love, E. J.; Taylor, P. M.; Murrell, J.; Whay, H. R.
Publisher
Wiley-Blackwell, Oxford, UK
Citation
Equine Veterinary Journal, 2012, 44, 2, pp 221-225
Abstract

Objectives: To examine the effect of including buprenorphine with detomidine for sedation of horses undergoing clinical procedures. Study design: Partially blinded, randomised, prospective clinical field trial. Animals: Eighty four client-owned horses scheduled for minor surgery or diagnostic...

Author(s)
Taylor, P.; Coumbe, K.; Henson, F.; Scott, D.; Taylor, A.
Publisher
Wiley-Blackwell, Oxford, UK
Citation
Veterinary Anaesthesia and Analgesia, 2014, 41, 1, pp 14-24
Abstract

Objective: To describe the pharmacokinetics and adverse effects of intravenous (IV) and sublingual (SL) buprenorphine in horses, and to determine the effect of sampling site on plasma concentrations after SL administration. Study design: Randomized crossover experiment; prospective study. Animals:...

Author(s)
Messenger, K. M.; Davis, J. L.; LaFevers, D. H.; Barlow, B. M.; Posner, L. P.
Publisher
Wiley-Blackwell, Oxford, UK
Citation
Veterinary Anaesthesia and Analgesia, 2011, 38, 4, pp 374-384
Abstract

Primary care guidelines provide a reference point to guide clinicians based on a systematic review of the literature, contextualised by expert clinical opinion. These guidelines develop a modification of the GRADE framework for assessment of research evidence (vetGRADE) and applied this to a range...

Author(s)
Bowen, I. M.; Redpath, A.; Burford, J. H.; Hallowell, G. D.; Dugdale, A.; Watson, T.; Lloyd, D.
Publisher
Wiley, Oxford, UK
Citation
Equine Veterinary Journal, 2020, 52, 1, pp 13-27

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