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Abstract

Equid herpesvirus 1 is one of the most common viral pathogens in the horse population and is associated with respiratory disease, abortion and still-birth, neonatal death and neurological disease. A single point mutation in the DNA polymerase gene (ORF30: A2254G, N752D) has been widely associated...

Author(s)
Sutton, G.; Thieulent, C.; Fortier, C.; Hue, E. S.; Marcillaud-Pitel, C.; Pléau, A.; Deslis, A.; Guitton, E.; Paillot, R.; Pronost, S.
Publisher
MDPI AG, Basel, Switzerland
Citation
Viruses, 2020, 12, 10,
Abstract

Equid alpha-herpesviruses (EHV) are responsible for different diseases in equine population. EHV-1 causes respiratory diseases, abortions and nervous disorders, EHV-4 causes respiratory diseases and sporadic abortion, while EHV-3 is responsible of equine coital exanthema. In view of the lack of...

Author(s)
Thieulent, C. J.; Hue, E. S.; Fortier, C. I.; Dallemagne, P.; Zientara, S.; Munier-Lehmann, H.; Hans, A.; Fortier, G. D.; Pitel, P. H.; Vidalain, P. O.; Pronost, S. L.
Publisher
Elsevier, Amsterdam, Netherlands
Citation
Virology, 2019, 526, pp 105-116
Abstract

The purpose of the study reported here was to describe the bioavailability and pharmacokinetics of aciclovir after intravenous and oral administration to horses. Six healthy adult horses were used in a randomized cross-over study with a 3×3 Latin square design. Three treatments were administered to ...

Author(s)
Bentz, B. G.; Maxwell, L. K.; Erkert, R. S.; Royer, C. M.; Davis, M. S.; MacAllister, C. G.; Clarke, C. R.
Publisher
American College of Veterinary Internal Medicine, Lakewood, USA
Citation
Journal of Veterinary Internal Medicine, 2006, 20, 3, pp 589-594
Abstract

Based on the anecdotally reported eradication of a sarcoid using aciclovir cream, the curative potential of this ointment was investigated in 22 sarcoid-affected horses referred to the Equine Clinic Tillysburg, Austria, between 2006 and 2009. Sarcoid disease was diagnosed by clinical examination...

Author(s)
Stadler, S.; Kainzbauer, C.; Haralambus, R.; Brehm, W.; Hainisch, E.; Brandt, S.
Publisher
BMJ Publishing Group, London, UK
Citation
Veterinary Record, 2011, 168, 7, pp 187
AbstractFull Text

Background: The equine sarcoid corresponds to one third of equine tumors, and may present as single or multiple and in six different shapes. The etiology is still unknown, but it brings with it some predisposing factors. Confirmatory diagnosis is made based on histopathology evaluation. There are...

Author(s)
Jacobsen, T. K.; Bastiani, G. de; Vargas, M. de; Silva, M. S. da; Goetten, A. L. F.; Figueiró, G. M.; Ramos, A. T.
Publisher
Universidade Federal do Rio Grande do Sul, Faculdade de Veterinária, Porto Alegre, Brazil
Citation
Acta Scientiae Veterinariae, 2020, 48, (Suppl 1): 523,
Abstract

Objective: To determine the pharmacokinetics of aciclovir administered intravenously (IV) and orally to healthy adult horses. Design: Random crossover with an approximate 1-week washout period between trials. Setting: University veterinary medical teaching hospital. Animals: Six healthy adult...

Author(s)
Wilkins, P. A.; Papich, M.; Sweeney, R. W., III
Publisher
Blackwell Publishing, Oxford, UK
Citation
Journal of Veterinary Emergency and Critical Care, 2005, 15, 3, pp 174-178
AbstractFull Text

Sarcoids are fibroblast and non-metastatic skin tumors, representing the most common tumors in horses. Its etiopathogenesis is related to bovine papillomavirus type 1 and type 2 infections, being the transmission and dissemination to other parts of the body of the same animal associated with bites, ...

Author(s)
Abreu, D. B. de; Cunha, M. E. N. da; Silva, E. N. da; Menezes, R. V.; Ferreira, M. M.; Araújo, A. L. de; Ayres, M. C. C.
Publisher
Pubvet, Maringá, Brazil
Citation
PUBVET, 2018, 12, 2, pp 1-7
AbstractFull Text

Equid alphaherpesvirus type 1 (EHV-1) is distributed worldwide and is a major agent of abortion, respiratory and neurological disease in horses. No specific treatment is available for EHV-1 infection, yet the potential of antiviral therapy has been explored. In this study we investigated the in...

Author(s)
Oliveira, A. L. de; Cargnelutti, J. F.; Mortari, A. P. G.; Flores, E. F.; Weiblen, R.
Publisher
Centro de Ciências Rurais, Universidade Federal de Santa Maria, Santa Maria, Brazil
Citation
Ciência Rural, 2018, 48, 12, pp e20180085
Abstract

OBJECTIVE: To determine whether prophylactic administration of valacyclovir hydrochloride versus initiation of treatment at the onset of fever would differentially protect horses from viral replication and clinical disease attributable to equine herpesvirus type-1 (EHV-1) infection. ANIMALS: 18...

Author(s)
Maxwell, L. K.; Bentz, B. G.; Gilliam, L. L.; Ritchey, J. W.; Pusterla, N.; Eberle, R.; Holbrook, T. C.; McFarlane, D.; Rezabek, G. B.; Meinkoth, J.; Whitfield, C.; Goad, C. L.; Allen, G. P.
Publisher
American Veterinary Medical Association, Schaumburg, USA
Citation
American Journal of Veterinary Research, 2017, 78, 10, pp 1126-1139
Abstract

Since vaccination may not prevent disease, antiherpetic drugs have been investigated for the therapy of several equine herpesviruses. Drug efficacy has been assessed in horses with disease, but most evidence is in vitro, in other species, or empirical. Oral valacyclovir is most often administered...

Author(s)
Maxwell, L. K.
Publisher
Saunders, An Imprint of Elsevier, Philadelphia, USA
Citation
Veterinary Clinics of North America, Equine Practice, 2017, 33, 1, pp 99-125

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