The treatment of periorbitol equine sorcoids can be challenging for practitioners and owners as well. As reported for equine sorcoids in general, tumor growth is independent from gender and can affect horses of all ages. Furthermore the pathogenesis can be multifactoriol and all six types reported...

Equid herpesvirus 1 is one of the most common viral pathogens in the horse population and is associated with respiratory disease, abortion and still-birth, neonatal death and neurological disease. A single point mutation in the DNA polymerase gene (ORF30: A2254G, N752D) has been widely associated...

This paper reports on the use of acyclovir in the treatment of sarcoid in 4 affected horses presented at the Large Animal Veterinary Hospital of the Federal University of Lavras - UFLA, Brazil. Case 1 had lesions on the right ear, region of the masseter muscle of the right side of the face, neck,...

Based on the anecdotally reported eradication of a sarcoid using aciclovir cream, the curative potential of this ointment was investigated in 22 sarcoid-affected horses referred to the Equine Clinic Tillysburg, Austria, between 2006 and 2009. Sarcoid disease was diagnosed by clinical examination...

Objective: To determine the pharmacokinetics of aciclovir administered intravenously (IV) and orally to healthy adult horses. Design: Random crossover with an approximate 1-week washout period between trials. Setting: University veterinary medical teaching hospital. Animals: Six healthy adult...

Background: The equine sarcoid corresponds to one third of equine tumors, and may present as single or multiple and in six different shapes. The etiology is still unknown, but it brings with it some predisposing factors. Confirmatory diagnosis is made based on histopathology evaluation. There are...

OBJECTIVE: To determine whether prophylactic administration of valacyclovir hydrochloride versus initiation of treatment at the onset of fever would differentially protect horses from viral replication and clinical disease attributable to equine herpesvirus type-1 (EHV-1) infection. ANIMALS: 18...

This issue contains 7 papers on pharmacokinetics and analytical determination of acyclovir in Asian elephant calves (Elephas maximus), aspects in controlled drug delivery for topical applications in veterinary medicine, physiological and pharmacological actions of glucagon like peptide-1 (GLP-1) in ...

Since vaccination may not prevent disease, antiherpetic drugs have been investigated for the therapy of several equine herpesviruses. Drug efficacy has been assessed in horses with disease, but most evidence is in vitro, in other species, or empirical. Oral valacyclovir is most often administered...

The purpose of the study reported here was to describe the bioavailability and pharmacokinetics of aciclovir after intravenous and oral administration to horses. Six healthy adult horses were used in a randomized cross-over study with a 3×3 Latin square design. Three treatments were administered to ...