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Abstract

Background: Although acetylsalicylic acid (ASA) is not frequently used as a therapeutic agent in horses, its metabolite SA is of special interest in equestrianism since it is a natural component of many plants used as horse feed. This led to the establishment of thresholds by horse sport...

Author(s)
Buntenkötter, K.; Osmers, M.; Schenk, I.; Schänzer, W.; Machnik, M.; Düe, M.; Kietzmann, M.
Publisher
BioMed Central Ltd, London, UK
Citation
BMC Veterinary Research, 2017, 13, 28, pp (19 January 2017)
Abstract

The reasons for this prospective experimental study were to determine a dosing scheme with loading and maintenance dose of aspirin inducing inhibition of platelet function measured by whole blood impedance aggregometry. Ten horses received aspirin orally in the morning with one loading dose of...

Author(s)
Roscher, K. A.; Failing, K.; Schenk, I.; Moritz, A.
Publisher
Wiley, Oxford, UK
Citation
Journal of Veterinary Pharmacology and Therapeutics, 2017, 40, 6, pp e16-e22
Abstract

Background: Reserpine is a popular drug in the equine industry for long-term tranquilisation. Clinical observations revealed that blood from horses receiving oral reserpine was hypercoagulable. No studies have documented the pharmacokinetics of orally administered reserpine nor the effects of...

Author(s)
Gilbertie, J. M.; Davis, J. L.; Davidson, G. S.; McDonald, A. M.; Schirmer, J. M.; Schnabel, L. V.
Publisher
Wiley, Oxford, UK
Citation
Equine Veterinary Journal, 2019, 51, 4, pp 537-543
Abstract

We evaluated the effects of nonselective cyclooxygenase (COX)-1/COX-2 inhibitors (acetylsalicylic acid, indomethacin, ibuprofen, flunixin meglumine, phenylbutazone), preferential COX-2 inhibitors (diclofenac, meloxicam, carprofen), selective COX-1 inhibitor (SC-560), and selective COX-2 inhibitors...

Author(s)
Menozzi, A.; Pozzoli, C.; Poli, E.; Tagliaferri, L.; Placenza, G.; Bertini, S.
Publisher
University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic
Citation
Acta Veterinaria Brno, 2018, 87, 2, pp 99-107
Abstract

Background: Critically ill horses are susceptible to thrombotic disease, which might be related to increased platelet reactivity and activation. Objectives: To compare the effect of oral clopidogrel and aspirin (ASA) on equine platelet function. Animals: Six healthy adult horses. Methods: Horses...

Author(s)
Brainard, B. M.; Epstein, K. L.; LoBato, D.; Kwon, S.; Papich, M. G.; Moore, J. N.
Publisher
Blackwell Publishing Ltd, Oxford, UK
Citation
Journal of Veterinary Internal Medicine, 2011, 25, 1, pp 116-122
Abstract

Objective - To evaluate the roles of 5-hydroxytryptamine (5-HT), thromboxane A2 (TxA2), and platelet-activating factor (PAF) in endotoxin-induced digital hypoperfusion in horses. Animals - 6 healthy adult Thoroughbreds. Procedures - Horses were treated with IV administration of saline (0.9% NaCl)...

Author(s)
Menzies-Gow, N. J.; Sepulveda, M. F.; Bailey, S. R.; Cunningham, F. M.; Elliott, J.
Publisher
American Veterinary Medical Association, Schaumburg, USA
Citation
American Journal of Veterinary Research, 2008, 69, 2, pp 199-207
Abstract

OBJECTIVE: To evaluate the effects of treatment of horses with standard platelet inhibitors on ex vivo inhibition of platelet activation by equine herpesvirus type I (EHV-I). ANIMALS: II healthy adult horses. PROCEDURES: In a double-blinded, placebo-controlled crossover study, horses were treated...

Author(s)
Hernandez, D.; Yeo WeeMing; Brooks, M. B.; Ness, S. L.; Divers, T. J.; Stokol, T.
Publisher
American Veterinary Medical Association, Schaumburg, USA
Citation
American Journal of Veterinary Research, 2016, 77, 12, pp 1366-1373
Abstract

Background: This study investigated synovial concentrations of acetylsalicylic acid (ASA) and its metabolite salicylic acid (SA) in the equine fetlock joint following systemic administration of ASA. Salicylates were chosen because SA is the only nonsteroidal anti-inflammatory drug for which...

Author(s)
Friebe, M.; Schumacher, S.; Stahl, J.; Kietzmann, M.
Publisher
BioMed Central Ltd, London, UK
Citation
BMC Veterinary Research, 2013, 9, 56, pp (26 March 2013)
Abstract

Inflammation-induced P-selectin (CD62P) expression on platelets and endothelial cells facilitates interactions among platelets and polymorphonuclear leukocytes (PMN), and can also promote coagulation. The effects of clopidogrel and aspirin (ASA) on equine platelet CD62P expression were...

Author(s)
Brainard, B. M.; Epstein, K. L.; LoBato, D. N.; Kwon, S. Y.; Darien, B. J.; Hurley, D. J.; Moore, J. N.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Veterinary Immunology and Immunopathology, 2012, 149, 1/2, pp 119-125
AbstractFull Text

Nonsteroidal anti-inflammatory drug (NSAID) selection in horses should be based on label indications, adverse effect profile, and efficacy, with consideration of the pathogenesis of the disease and mechanism of pain (i.e., inflammatory vs mechanical pain).

Author(s)
Banse, H. E.; Cribb, A. E.
Publisher
American Association of Equine Practitioners (AAEP), Lexington, USA
Citation
Proceedings of the 61st Annual Convention of the American Association of Equine Practitioners, Las Vegas, Nevada, USA, December 5-9, 2015, 2015, pp 532-536

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