Background: Respiratory disease is common in guinea pigs (Cavia porcellus). As obligate nasal breathers, disease of the upper airway can result in significant dyspnea. Nasopharyngeal stenosis is defined as a luminal narrowing of the nasopharynx, which extends from the choana to the caudal margin of ...

Farfarae Flos is the dried flower buds of Tussilago farfara L. which is widely used to treat allergic and inflammatory diseases in Chinese folk. Tussilagone (TSL), a sesquiterpene compound purified from Farfarae Flos, has been confirmed the main active component in the plant. However, its...

Ethnopharmacological relevance: Artemisia ordosica Krasch. (AOK) has been used for rheumatic arthritis, cold headache, sore throat, etc. in traditional Chinese/Mongolian medicine and is used for nasosinusitis by local Mongolian "barefoot" doctors. Up to now, their mechanisms are still unclear. Aim: ...

Background: Allergic rhinitis (AR) is a chronic inflammatory disease of the nasal airways. Many therapies do not have immediate effects, even which have side-effects. However, the effects of Xingbi gel for the treatment of AR was investigated. Objective: We investigated the effects of Xingbi gel on ...

Objective: To prepare mometasone furoate nasal gel, and to evaluate its curative effect on allergic rhinitis. Methods: 2% Avicel® RC-591 was used as the groundmass to prepare mometasone furoate nasal gel by anti-solvent co-precipitation method. Guinea pig model of allergic rhinitis was established...

In the present experiments, the possible role of curcumin in ovalbumin induced allergic rhinitis in guinea pig model was investigated. Various allergic rhinitis symptoms viz sneezing, rubbing frequencies, lacrimation and nasal congestion at various humidity conditions as well as on repeated...

Objective: To observe the effects of total alkaloids of processed Radix Aconiti Lateralis on blood histamine contents and pathomorphological changes in nasal mucosa of allergic rhinitis (AR) guinea pigs and assay LD₅₀ of total alkaloids of processed Radix Aconiti Lateralis in guinea pigs to...

Ganoderma lucidum (GL), an oriental medical mushroom, has been used in Asia for the prevention and treatment of a variety of diseases. However, the effect of GL on allergic rhinitis has not been well defined. The current study describes the inhibitory effect of GL on the biphasic nasal blockage and ...

Objective: To explore the mechanism of Xiaoqinglong decoction on allergic rhinitis guinea-pig model. Methods: Allergic rhinitis group was immunized by intraperitoneal injection and intranasal instillation of Ovalbumin (OVA). The guinea pigs were divided into six groups: control group (group A),...

Recent studies of several animal models have shown beneficial effects of probiotics against allergic responses. However, few reports have examined the effects of probiotics on allergic nasal symptoms such as sneezing and nasal obstruction in animal models of allergic rhinitis. This study evaluated...