Organophosphorus compounds (OPs) include nerve agents and insecticides that potently inhibit acetylcholinesterase (AChE), an essential enzyme found throughout the nervous system. High exposure levels to OPs lead to seizures, cardiac arrest, and death if left untreated. Oximes are a critical piece...
Author(s)
Nichols, R. H.; Chambers, J. E.
Publisher
Elsevier Ireland, Shannon, Irish Republic
Citation
Toxicology, 2021, 452,
The purpose of the research is to study the cumulative properties of the long-acting preparation "Flyblock insecticidal tag". Materials and methods. The cumulative properties of the "Flyblock insecticidal tag" preparation were studied by the subchronic toxicity method on 20 male guinea pigs, which...
Author(s)
Mironenko, A. V.
Publisher
All-Russian K. I. Skryabin Scientific Research Institute of Helminthology, Moscow, Russia
Citation
Rossiiskii Parazitologicheskii Zhurnal, 2020, 3, pp 99-103
An adult male guinea pig (Cavia porcellus) with a 1-month history of hind limb paresis, torticollis, and seizures was euthanized and submitted for necropsy. Gross examination was unremarkable, but histologic examination revealed multifocal eosinophilic and lymphoplasmacytic choriomeningitis and...
Author(s)
Southard, T.; Bender, H.; Wade, S. E.; Grunenwald, C.; Gerhold, R. W.
Publisher
American College of Veterinary Pathologists Inc., Lawrence, USA
Citation
Veterinary Pathology, 2013, 50, 3, pp 560-562
The neuropathologic mechanisms after exposure to lethal doses of nerve agent are complex and involve multiple biochemical pathways. Effective treatment requires drugs that can simultaneously protect by reversible binding to the acetylcholinesterase (AChE) and blocking cascades of seizure related...
Author(s)
Wang, Y.; Wei, Y. L.; Oguntayo, S.; Doctor, B. P.; Nambiar, M. P.
Publisher
Elsevier Science Ireland Ltd., Shannon, Irish Republic
Citation
Chemico-Biological Interactions, 2013, 203, 1, pp 120-124
Seizures and status epilepticus, which may contribute to brain injury, are common consequences of exposure to organophosphorus (OP) cholinesterase inhibitors. Effective management of these seizures is critical. To investigate the efficacy of nasal midazolam as an anticonvulsive treatment for OP...
Author(s)
Gilat, E.; Goldman, M.; Lahat, E.; Levy, A.; Rabinovitz, I.; Cohen, G.; Brandeis, R.; Amitai, G.; Alkalai, D.; Eshel, G.
Publisher
Springer-Verlag, Berlin, Germany
Citation
Archives of Toxicology, 2003, 77, 3, pp 167-172
Context. Human butyrylcholinesterase (huBuChE) has potential utility as a post-exposure therapy following percutaneous nerve agent poisoning as there is a slower absorption of agent by this route and hence a later onset of poisoning. Methods. We used surgically implanted radiotelemetry devices to...
Author(s)
Mumford, H.; Price, M. E.; Lenz, D. E.; Cerasoli, D. M.
Publisher
Informa Healthcare, London, UK
Citation
Clinical Toxicology, 2011, 49, 4, pp 287-297
The pharmacological screening of aqueous extract of C. infortunatum for maximal electroshock (MES) and pentylene tetrazole seizure (PTZ), Force Locomotor Activity (FLA), Conditioned Avoidance Response (CAR), analgesic activity in albino rats and local anaesthetic effect in guinea pigs were...
Author(s)
Kumari, M.; Prasad, R.; Roy, B. K.
Publisher
Indian Association for the Advancement of Veterinary Research, Bareilly, India
Citation
Indian Journal of Veterinary Research, 2008, 17, 2, pp 25-31
Scopolamine (SCP) is an anticholinergic drug used clinically for decades to treat motion sickness, as a surgical preanesthetic, and as a smooth muscle antispasmodic. It has also been used experimentally as a pretreatment and/or treatment adjunct to mitigate the toxic sequelae of organophosphorus...
Author(s)
Koplovitz, I.; Schulz, S.
Publisher
Association of Military Surgeons of the US, Bethesda, USA
Citation
Military Medicine, 2010, 175, 11, pp 878-882
The causes, diagnosis, treatment and control of skin diseases affecting rabbits and rodents were discussed.
Publisher
World Small Animal Veterinary Association, Bangkok, Thailand
Citation
40th World Small Animal Veterinary Association Congress, Bangkok, Thailand, 15-18 May, 2015. Proceedings book, 2015, pp 485-487
This article describes the suspected adverse drug reactions in horses, cattle, swine, sheep and goats reported by Swedish veterinarians during 2007 and 2008. In coming articles the adverse reactions reported in dog, cat, rabbit and guinea pig and human reactions to veterinary drugs, will be...
Publisher
Sveriges Veterinärförbund, Stockholm, Sweden
Citation
Svensk Veterinärtidning, 2009, 61, 13, pp 11-19