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Methadone was administered orally at 25 mg/kg body wt. to non-pregnant, pregnant and lactating guinea pigs. Plasma concn. and elimination half-life values were increased at 50-55 days of pregnancy compared with non-pregnant values. Elimination half-life at 2 days post partum was shorter than during ...

Pak, R. C. K.; Ecobichon, D. J.
Drug Metabolism and Disposition, 9, 2, pp 170-171