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Abstract

Over the years, management of advanced peptic ulcers used to be a nightmare and in most cases surgery is resorted to. This study was carried out to investigate the anti-ulcer activities of the oil extract of Balanites aegyptiaca seed in guinea pigs. Thirty guinea pigs weighing between 200 and 440.8 ...

Author(s)
Eze, C. A.; Anyogu, D. C.; Nwogu, I. C.; Adamu, S. S.
Publisher
Academic Journals, Nairobi, Kenya
Citation
Journal of Medicinal Plants Research, 2013, 7, 34, pp 2533-2537
Abstract

Objective: To investigate the effect of crude methanolic extract of Combretum racemosum (C. racemosum) leaves on histamine-stimulated gastric secretion in rats. Methods: Phytochemical and acute toxicity tests were performed. Anti-secretory activity of C. racemosum extract was investigated in...

Author(s)
Okwuosa, C. N.; Azubike, N. C.; Nwachukwu, D. C.; Onuba, A. C.; Shu, E. N.
Publisher
Journal of Coastal Life Medicine, Haikou, China
Citation
Journal of Coastal Life Medicine, 2017, 5, 2, pp 77-81
Abstract

UL-409, a herbal formulation prepared from 6 medicinal plants (used in Ayurvedic medicine), was investigated for its possible ulcero-protective activity in Wistar rats (both sexes) and male guineapigs. Oral administration of UL-409 at a daily dose of 600 mg/kg for 7 days significantly prevented the ...

Author(s)
Mitra, S. K.; Gopumadhavan, S.; Hemavathi, T. S.; Muralidhar, T. S.; Venkataranganna, M. V.
Citation
Journal of Ethnopharmacology, 1996, 52, 3, pp 165-169
Abstract

The fixed oil of O. sanctum [O. tenuiflorum] seeds was found to possess significant antiulcer activity against aspirin-, indomethacin-, alcohol-, histamine-, reserpine-, serotonin- and stress-induced ulceration in experimental animal models (rats and guineapigs) at 1-3 ml/kg, i.p. Significant...

Author(s)
Surender Singh; Majumdar, D. K.
Citation
Journal of Ethnopharmacology, 1999, 65, 1, pp 13-19
Abstract

The fixed oil of O. basilicum was found to possess significant antiulcer activity against aspirin-, indomethacin-, alcohol-, histamine-, reserpine-, serotonin- and stress-induced ulceration in experimental animal models (rats and guineapigs). Significant inhibition was also observed in...

Author(s)
Surender Singh
Citation
Indian Journal of Experimental Biology, 1999, 37, 3, pp 253-257
Abstract

C. procera has been widely used in the Indian traditional medicinal system for the treatment of several disease conditions. The antiulcer activity of an extract of roots of C. procera (obtained from a commercial source in India) was investigated using different in vivo ulcer models. C. procera...

Author(s)
Basu, A.; Sen, T.; Pal, S.; Mascolo, N.; Capasso, F.; Chaudhuri, A. K. N.
Citation
Phytotherapy Research, 1997, 11, 2, pp 163-165
Abstract

A methanol extract of roots of S. longepedunculata [S. longipedunculata] (collected from Nigeria) induced spasmodic actions on the gastrointestinal tract of mice and rats. An increase in the propulsive movements of the intestinal contents, as well as a reduction in gastric emptying time, was...

Author(s)
Olajide, O. A.; Ajayi, F. F.; Ekhelar, A. I.; Awe, S. O.; Makinde, J. M.; Alada, A. R. A.
Citation
Pharmaceutical Biology, 1999, 37, 2, pp 134-137
Abstract

Purified T-2 toxin dissolved in saline-dimethylsulphoxide (DMSO) 10:1 (v/v) was administered by gastric intubation in single doses of 1.85, 2.52, 3.45 and 4.66 mg/kg body weight to male guinea-pigs. The acute oral LD50 in the male guinea-pig was estimated to be 3.06 (2.38-3.93) mg/kg. Single doses...

Author(s)
DeNicola, D. B.; Rebar, A. H.; Carlton, W. W.
Citation
Food and Cosmetics Toxicology, 1978, 16, 6, pp 601-609
Abstract

Guineapigs deprived of food for 1 to 5 days but allowed drinking water developed duodenal but not gastric lesions characterized by severe villous atrophy and ulceration. Histological and histochemical studies on stomach and small intestine of guineapigs weighing 200 to 300 g, killed after 1, 2, 3,...

Author(s)
Jervis, H. R.; Sheahan, D. G.; Sprinz, H.
Citation
Laboratory Investigation, 1973, 28, 4, pp 501-513
Abstract

The gastroprotective effects of an extract of aerial parts of T. stocksianum (collected from the Khor-Fakann area, United Arab Emirates) were investigated in rats. Oral, but not i.p., administration of the extract exhibited dose-dependent gastric cytoprotective effects against ulcer formation...

Author(s)
Wasfi, I. A.; Bashir, A. K.; Amiri, M. H.; Abdalla, A. A.; Banna, N. R.; Tanira, M. O. M.
Citation
International Journal of Pharmacognosy, 1995, 33, 2, pp 164-171

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