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VetMed Resource

Veterinary information to support practice, based on evidence and continuing education

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Abstract

Ivermectin is considered a very safe drug; however, there are reports of toxic effects in particularly sensitive populations or due to accidental overdose. The aim of this study was (1) to further characterize the central and peripheral toxic effects of ivermectin in animals and (2) to determine...

Author(s)
Trailović, S. M.; Nedeljković, J. T.
Publisher
Japanese Society of Veterinary Science, Tokyo, Japan
Citation
Journal of Veterinary Medical Science, 2011, 73, 5, pp 591-599
Abstract

The inotropic effect of diazepam, a benzodiazepine derivative, and its mechanism of action were examined using guineapig heart and single ventricular cell preparations. In Langendorff hearts and right ventricular free-wall preparations, diazepam (10 to 100 µM) produced a monophasic negative...

Author(s)
Hara, Y.; Kobayashi, H.; Ooshiro, S.; Futamura, K.; Nishino, T.; Chugun, A.; Temma, K.; Kondo, H.
Publisher
Japanese Society of Veterinary Science, Tokyo, Japan
Citation
Journal of Veterinary Medical Science, 2001, 63, 2, pp 135-143
Abstract

The effects of diazepam on the inotropic response elicited by histamine on isolated guineapig papillary muscle were investigated. The responses of electrically driven papillary muscle to histamine and cyclic AMP-related inotropic agents were recorded in the absence and in the presence of diazepam....

Author(s)
Hara, Y.; Kaigo, H.; Minami, I.; Watanabe, H.; Gomi, H.; Nishimura, H.; Chugun, A.; Kondo, H.
Citation
Journal of Veterinary Pharmacology and Therapeutics, 1998, 21, 5, pp 375-379