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Abstract

The anticholinergic effects of 7 benzodiazepines, bromazepam, camazepam, chlordiazepoxide, diazepam, lorazepam, medazepam and triazolam, were compared by examining their inhibitory effects on the acetylcholine receptor-operated potassium current (IK.ACh) in guinea-pig atrial myocytes. All of these...

Author(s)
Okada, M.; Mizuno, W.; Nakarai, R.; Matada, T.; Yamawaki, H.; Hara, Y.
Publisher
Japanese Society of Veterinary Science, Tokyo, Japan
Citation
Journal of Veterinary Medical Science, 2012, 74, 7, pp 879-884
Abstract

The currently fielded pre-hospital therapeutic regimen for the treatment of organophosphorus (OP) poisoning in the United States (U.S.) is the administration of atropine in combination with an oxime antidote (2-PAM Cl) to reactivate inhibited acetylcholinesterase (AChE). Depending on clinical...

Author(s)
Wilhelm, C. M.; Snider, T. H.; Babin, M. C.; Jett, D. A.; Platoff, G. E., Jr.; Yeung, D. T.
Publisher
Elsevier Inc, Orlando, USA
Citation
Toxicology and Applied Pharmacology, 2014, 281, 3, pp 254-265
Abstract

The inotropic effect of diazepam, a benzodiazepine derivative, and its mechanism of action were examined using guineapig heart and single ventricular cell preparations. In Langendorff hearts and right ventricular free-wall preparations, diazepam (10 to 100 µM) produced a monophasic negative...

Author(s)
Hara, Y.; Kobayashi, H.; Ooshiro, S.; Futamura, K.; Nishino, T.; Chugun, A.; Temma, K.; Kondo, H.
Publisher
Japanese Society of Veterinary Science, Tokyo, Japan
Citation
Journal of Veterinary Medical Science, 2001, 63, 2, pp 135-143
Abstract

This study was carried out to observe the effects of diazepam and baclofen on the urinary bladder smooth muscle in guineapigs. 15 guineapigs weighing 250-300 g were employed. The ribbon-like tissue samples were prepared from the isolated urinary bladder. The tissue strips were placed into the...

Author(s)
Sert, M.; Pİșkİn, İ.
Publisher
Ankara Üniversitesi, Veteriner Fakültesi Dekanlığ, Ankara, Turkey
Citation
Ankara Üniversitesi Veteriner Fakültesi Dergisi, 2004, 51, 3, pp 189-193
Abstract

The effects of diazepam on the inotropic response elicited by histamine on isolated guineapig papillary muscle were investigated. The responses of electrically driven papillary muscle to histamine and cyclic AMP-related inotropic agents were recorded in the absence and in the presence of diazepam....

Author(s)
Hara, Y.; Kaigo, H.; Minami, I.; Watanabe, H.; Gomi, H.; Nishimura, H.; Chugun, A.; Kondo, H.
Citation
Journal of Veterinary Pharmacology and Therapeutics, 1998, 21, 5, pp 375-379
Abstract

Detailed information is given on the dosage and method of application of the analgesics buprenorphine and butorphanol for small mammals such as rabbits, rats, guineapigs, chinchilla, mice and ferrets. It is noted that these drugs should not be given to hamsters, and that care should be used when...

Author(s)
Henke, J.
Publisher
Schlütersche Verlagsgesellschaft mbH & Co. KG, Hannover, Germany
Citation
Praktische Tierarzt, 2010, 91, 4, pp 294-304
Abstract

Author(s)
Richardson, C.; Flecknell, P.
Publisher
British Small Animal Veterinary Association, Quedgeley, UK
Citation
BSAVA manual of rodents and ferrets, 2009, pp 63-72
Abstract

Atropine (ATR), HI-6 (1-2 hydroxyiminomethyl-1-pyridino-3-(4-carbamoyl-1-pyridino)-2-oxapropane dichloride) and various combinations of these were evaluated against lethal poisoning by the chemical warfare agents soman (GD) and tabun (GA) in guineapigs. The effect of adjunctive diazepam treatment...

Author(s)
Koplovitz, I.; Menton, R.; Matthews, C.; Shutz, M.; Nalls, C.; Kelly, S.
Citation
Drug and Chemical Toxicology, 1995, 18, 2/3, pp 119-136
Abstract

Author(s)
Flecknell, P.
Publisher
Veterinary Business Development Ltd, Peterborough, UK
Citation
Veterinary Times, 2006, 36, 49, pp 16-17
Abstract

Author(s)
Kottwitz, J.; Kelleher, S.
Publisher
Zoological Education Network, Lake Worth, USA
Citation
Exotic DVM, 2003, 5, 5, pp 23-25

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