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Abstract

The aim of this paper is to investigate the effects of ghrelin on delayed gastrointestinal transit in streptozotocin-induced diabetic guinea pigs. A diabetic guinea pig model was produced by intraperitoneal (i. p.) injection of streptozotocin (STZ, 280 mg/kg). Diabetic guinea pigs were randomized...

Author(s)
Qiu WenCai; Yang ChengGuang; Yan Jun; Wang ZhiGang; Zheng Qi
Publisher
Academic Journals, Nairobi, Kenya
Citation
African Journal of Pharmacy and Pharmacology, 2012, 6, 10, pp 702-707
Abstract

The mechanism of imidazole-induced contraction on the bovine tracheal smooth muscle was investigated. Imidazole induced muscle contraction in a concentration-dependent manner on bovine, porcine and guinea-pig tracheas, but not in rat or mouse. In bovine tracheas, imidazole was cumulatively applied...

Author(s)
Kaneda, T.; Kanda, H.; Tajima, T.; Urakawa, N.; Shimizu, K.
Publisher
Japanese Society of Veterinary Science, Tokyo, Japan
Citation
Journal of Veterinary Medical Science, 2018, 80, 2, pp 341-345
Abstract

Aqueous extract of the spines of the brown bullhead catfish (Ameiurus nebulosus Lesueur, 1819) caused contraction of the guinea-pig small intestine in vitro, a widely-used preparation in pharmacology. The action is dependent on extracellular Ca2+, and probably takes place on the smooth muscle...

Author(s)
Barthó, L.; Sándor, Z.; Bencsik, T.
Publisher
Akadémiai Kiadó, Budapest, Hungary
Citation
Acta Biologica Hungarica, 2018, 69, 2, pp 135-143
Abstract

Purpose: To study the effect of solvent fractions of the crude extract of liushenqu on gastrointestinal motility in guinea pigs, and the mechanism of action. Methods: The effects of solvent fractions of crude extract of liushenqu (LSQ) on receptors in guinea pig isolated small intestinal cells were ...

Author(s)
Zhang HongLing; Zeng HaiRong; Wang Ling; Qin Yi; Huang QinWan; Sun JiLin; Yao RenChuan
Publisher
University of Benin, Benin City, Nigeria
Citation
Tropical Journal of Pharmaceutical Research, 2019, 18, 5, pp 1089-1094
Abstract

This study was aimed to investigate the effect of the extract of Mentha longifolia on blood pressure and the possible mechanisms. In anesthetized rats, the crude extract of M. longifolia and aqueous and chloroform fractions caused a dosedependent fall in mean arterial pressure. Atropine...

Author(s)
Shah, A. J.; Bukhari, I. A.; Gilani, A. H.
Publisher
Bangladesh Pharmacological Society, Dhaka, Bangladesh
Citation
Bangladesh Journal of Pharmacology, 2016, 11, 4, pp 784-792
Abstract

Vitamin C (vitC) deficiency is associated with increased cardiovascular disease risk, but its specific interplay with arteriolar function is unclear. This study investigates the effect of vitC deficiency in guinea pigs on plasma biopterin status and the vasomotor responses in coronary arteries...

Author(s)
Skovsted, G. F.; Tveden-Nyborg, P.; Lindblad, M. M.; Hansen, S. N.; Lykkesfeldt, J.
Publisher
MDPI AG, Basel, Switzerland
Citation
Nutrients, 2017, 9, 7, pp 691
Abstract

Ethnopharmacological relevance: Agastache mexicana has been used in traditional medicine for relief of abdominal pain and treatment of other diseases. Two subspecies have been identified: A. mexicana ssp. mexicana (AMM) and A. mexicana ssp. xolocotziana (AMX) and both are used traditionally without ...

Author(s)
Ventura-Martínez, R.; Rodríguez, R.; González-Trujano, M. E.; Ángeles-López, G. E.; Déciga-Campos, M.; Gómez, C.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Journal of Ethnopharmacology, 2017, 196, pp 58-65
Abstract

The relaxant effect of Portulaca oleracea L. on tracheal smooth muscles has been shown. The effect of the plant on muscarinic receptors of tracheal smooth muscles as one possible mechanism responsible for its relaxant effect was examined. Concentration response curves to methacholine were performed ...

Author(s)
Hashemzehi, M.; Khazdair, M. R.; Kiyanmehr, M.; Askari, V. R.; Boskabady, M. H.
Publisher
Medknow Publications, Mumbai, India
Citation
Indian Journal of Pharmaceutical Sciences, 2016, 78, 3, pp 388-394
Abstract

Background: Diabetic gastroparesis is a disabling condition with no consistently effective treatment. In normal animals, both ghrelin and its synthetic peptide, growth hormone releasing peptide 6 (GHRP-6), increase gastric emptying. Thus, we investigated the potential therapeutic significance of...

Author(s)
Qiu WenCai; Wang ZhiGang; Wang WeiGang; Yan Jun; Zheng Qi
Publisher
Chinese Medical Association (Beijing), Beijing, China
Citation
Chinese Medical Journal (Beijing), 2008, 121, 13, pp 1183-1188
Abstract

Objective: To investigate the vasodilatory effect of Thymus serrulatus (T. serrulatus) aqueous leaf extract on KCl (high K+, 80 mmol/L) induced precontracted isolated thoracic aorta rings on guinea pigs and the role of aorta endothelium on this action. Methods: Guinea pig thoracic aorta was removed ...

Author(s)
Bekesho Geleta; Mebrahtu Eyasu; Selamu Kebamo; Asfaw Debella; Eyasu Makonnen; Abiy Abebe
Publisher
Elsevier (Singapore) Pte Ltd, Hong Kong, China
Citation
Asian Pacific Journal of Tropical Biomedicine, 2015, 5, 1, pp 15-18

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