Guinea pigs (Cavia porcellus) are a frequently used species in research, often involving potentially painful procedures. Therefore, evidence-based recommendations regarding analgesia are critically needed to optimize their wellbeing. Our laboratory examined the efficacy of carprofen and...

Objective: To assess the agreement between an oscillometric device and invasive blood pressure (IBP) measurements in anesthetized healthy adult guinea pigs. Study design: Prospective experimental study. Animals: A total of eight adult Hartley guinea pigs. Methods: All animals were anesthetized; a...

Providing appropriate analgesia is essential in minimizing pain and maintaining optimal animal care and welfare in laboratory animals. Guinea pigs are common animal models in biomedical research, often requiring analgesic support. Here we evaluated the pharmacokinetics and efficacy of a...

Guinea pigs are a sociable and prolific species and routine or elective neutering is frequently performed to manage reproduction. Surgical neutering is mainly performed in males. as the technique is easier, and therefore less risky to perform than in females. Gaseous anaesthesia is preferred, and a ...

Objective: To investigate the pharmacokinetics and absolute oral bioavailability of meloxicam in guinea pigs. Study design: Prospective crossover study. Animals: A group of six healthy male Dunkin Hartley guinea pigs. Methods: A single dose of meloxicam (1.5 mg kg^-1) was administered orally and...

This article reviews the current literature on osteoarthritis in pet and laboratory guinea pigs. The associated clinical signs, diagnosis and treatment of osteoarthritis in pet guinea pigs will be discussed, with options for analgesia detailed. This condition is thought to be common in pet guinea ...

Acupuncture is being increasingly used in veterinary medicine in the management of wound healing and chronic pain. In this case study, a guinea pig responded to chronic back pain caused by fractures to multiple thoracic vertebral spinous processes and subsequent vertebral luxation, with severe...

Objective: To characterize alfaxalone administered subcutaneously (SC) in guinea pigs, both alone and in combination with dexmedetomidine and buprenorphine. Study design: Prospective, blinded, crossover study. Animals: A total of 15 healthy female guinea pigs weighing 400-600 g. Methods: Alfaxalone ...

Although guinea pigs (Cavia porcellus) have been used in research for more than a century and remain the most prevalent USDA-covered species, little has been elucidated regarding the recognition of clinical pain or analgesic efficacy in this species. We sought to assess pain in guinea pigs by using ...